(69 nodes) DNA replication network (Zymoseptoria tritici ST99CH3D7)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ZT3D7_G6633	Integrase catalytic domain-containing protein. (613 aa)
	ZT3D7_G9829	XPGI domain-containing protein. (693 aa)
	ZT3D7_G9813	AAA domain-containing protein. (351 aa)
	ZT3D7_G9396	Uncharacterized protein. (223 aa)
	ZT3D7_G9255	Exo84_C domain-containing protein. (722 aa)
	ZT3D7_G9274	Uncharacterized protein. (187 aa)
	ZT3D7_G9268	DNA helicase; Belongs to the MCM family. (959 aa)
	ZT3D7_G9084	Uncharacterized protein. (447 aa)
	ZT3D7_G9216	RPA_C domain-containing protein. (281 aa)
	ZT3D7_G9004	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (163 aa)
	ZT3D7_G8919	CBFD_NFYB_HMF domain-containing protein. (190 aa)
	ZT3D7_G8883	Reverse transcriptase Ty1/copia-type domain-containing protein. (162 aa)
	ZT3D7_G8673	Uncharacterized protein. (283 aa)
	ZT3D7_G8770	DNA helicase; Belongs to the MCM family. (732 aa)
	ZT3D7_G8210	AAA domain-containing protein. (398 aa)
	ZT3D7_G8525	Uncharacterized protein. (147 aa)
	ZT3D7_G7715	Uncharacterized protein. (599 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (810 aa)
	ZT3D7_G7396	Uncharacterized protein. (746 aa)
	ZT3D7_G7144	DNA helicase; Belongs to the MCM family. (876 aa)
	ZT3D7_G7083	DNA helicase; Belongs to the MCM family. (1063 aa)
	ZT3D7_G7259	DNA_pol_E_B domain-containing protein. (782 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (393 aa)
	ZT3D7_G6969	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (620 aa)
	ZT3D7_G6889	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (494 aa)
	ZT3D7_G6634	Reverse transcriptase Ty1/copia-type domain-containing protein. (115 aa)
	ZT3D7_G5191	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (510 aa)
	ZT3D7_G5070	AAA domain-containing protein. (357 aa)
	ZT3D7_G4851	Uncharacterized protein. (934 aa)
	ZT3D7_G5004	Zn(2)-C6 fungal-type domain-containing protein. (739 aa)
	ZT3D7_G4817	Uncharacterized protein. (261 aa)
	ZT3D7_G4699	Zds_C domain-containing protein. (959 aa)
	ZT3D7_G4534	Integrase catalytic domain-containing protein. (1328 aa)
	ZT3D7_G4206	DNA polymerase. (1478 aa)
	ZT3D7_G3451	Reverse transcriptase Ty1/copia-type domain-containing protein. (90 aa)
	ZT3D7_G3353	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (672 aa)
	ZT3D7_G3062	Uncharacterized protein. (106 aa)
	ZT3D7_G2635	DNA polymerase. (1107 aa)
	ZT3D7_G3027	AAA domain-containing protein. (1229 aa)
	ZT3D7_G2809	Uncharacterized protein. (452 aa)
	ZT3D7_G2573	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (335 aa)
	ZT3D7_G2012	CBFD_NFYB_HMF domain-containing protein. (268 aa)
	ZT3D7_G1921	DNA ligase. (884 aa)
	ZT3D7_G1884	Uncharacterized protein. (1758 aa)
	ZT3D7_G1295	Uncharacterized protein. (254 aa)
	ZT3D7_G1327	Replication factor C subunit 1. (1092 aa)
	ZT3D7_G855	Uncharacterized protein. (487 aa)
	ZT3D7_G601	Uncharacterized protein. (202 aa)
	ZT3D7_G806	Uncharacterized protein. (143 aa)
	ZT3D7_G187	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (917 aa)
	ZT3D7_G9891	DNA helicase; Belongs to the MCM family. (890 aa)
	ZT3D7_G9938	BRCT domain-containing protein. (213 aa)
	ZT3D7_G9927	RNase H domain-containing protein. (434 aa)
	ZT3D7_G10055	Uncharacterized protein. (1084 aa)
	ZT3D7_G9772	Macro domain-containing protein. (230 aa)
	ZT3D7_G10246	DNA ligase. (902 aa)
	ZT3D7_G10601	Integrase catalytic domain-containing protein. (1714 aa)
	ZT3D7_G10316	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2226 aa)
	ZT3D7_G11438	DNA polymerase. (1712 aa)
	ZT3D7_G11633	Gag_pre-integrs domain-containing protein. (255 aa)
	ZT3D7_G11630	Uncharacterized protein. (119 aa)
	ZT3D7_G11690	Uncharacterized protein. (435 aa)
	ZT3D7_G6648	Uncharacterized protein. (407 aa)
	ZT3D7_G6635	Uncharacterized protein. (204 aa)
	ZT3D7_G6044	RNase H domain-containing protein. (173 aa)
	ZT3D7_G5480	Vezatin domain-containing protein. (726 aa)
	ZT3D7_G11579	Reverse transcriptase Ty1/copia-type domain-containing protein. (90 aa)
	ZT3D7_G5545	AAA domain-containing protein. (408 aa)
	ZT3D7_G5477	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (332 aa)

Your Current Organism:

Zymoseptoria tritici ST99CH3D7

NCBI taxonomy Id: 1276538
Other names: Z. tritici ST99CH_3D7, Zymoseptoria tritici ST99CH_3D7

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	MCM7	A0A1X7RWS1	A0A1X7RYJ0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.805
FEN1	ZT3D7_G10246	A0A1X7RWS1	A0A1X7S6Q3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.965
FEN1	ZT3D7_G10316	A0A1X7RWS1	A0A1X7S6X7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.894
FEN1	ZT3D7_G11438	A0A1X7RWS1	A0A1X7S9A2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.832
FEN1	ZT3D7_G1327	A0A1X7RWS1	A0A1X7RFI7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication factor C subunit 1.	0.859
FEN1	ZT3D7_G1884	A0A1X7RWS1	A0A1X7RH41	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.969
FEN1	ZT3D7_G1921	A0A1X7RWS1	A0A1X7RH94	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.969
FEN1	ZT3D7_G2012	A0A1X7RWS1	A0A1X7RHI4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	CBFD_NFYB_HMF domain-containing protein.	0.795
FEN1	ZT3D7_G2573	A0A1X7RWS1	A0A1X7RJ26	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.754
FEN1	ZT3D7_G2635	A0A1X7RWS1	A0A1X7RKE3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.992
FEN1	ZT3D7_G2809	A0A1X7RWS1	A0A1X7RKC1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.545
FEN1	ZT3D7_G3027	A0A1X7RWS1	A0A1X7RKC8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA domain-containing protein.	0.940
FEN1	ZT3D7_G3353	A0A1X7RWS1	A0A1X7RL76	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.837
FEN1	ZT3D7_G4206	A0A1X7RWS1	A0A1X7RNQ3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.921
FEN1	ZT3D7_G5004	A0A1X7RWS1	A0A1X7RR13	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Zn(2)-C6 fungal-type domain-containing protein.	0.553
FEN1	ZT3D7_G5070	A0A1X7RWS1	A0A1X7RR81	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA domain-containing protein.	0.945
FEN1	ZT3D7_G5191	A0A1X7RWS1	A0A1X7RRK6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.	0.831
FEN1	ZT3D7_G5477	A0A1X7RWS1	A0A1X7RS85	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.991
FEN1	ZT3D7_G5480	A0A1X7RWS1	A0A1X7RTM7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Vezatin domain-containing protein.	0.991
FEN1	ZT3D7_G5545	A0A1X7RWS1	A0A1X7RSI6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA domain-containing protein.	0.939