STRINGSTRING
AGC43583.1 AGC43583.1 AGC49351.1 AGC49351.1 AGC48585.1 AGC48585.1 thiL thiL metK metK mtnP mtnP mtnA mtnA AGC48045.1 AGC48045.1 AGC48043.1 AGC48043.1 AGC47829.1 AGC47829.1 metXA metXA acsA-2 acsA-2 AGC47672.1 AGC47672.1 AGC47671.1 AGC47671.1 AGC47666.1 AGC47666.1 AGC47626.1 AGC47626.1 thiE thiE AGC46848.1 AGC46848.1 AGC46716.1 AGC46716.1 AGC46574.1 AGC46574.1 dxs dxs AGC46307.1 AGC46307.1 AGC46276.1 AGC46276.1 folD-2 folD-2 AGC45975.1 AGC45975.1 AGC45969.1 AGC45969.1 thiG thiG AGC45967.1 AGC45967.1 AGC45885.1 AGC45885.1 AGC45775.1 AGC45775.1 AGC45774.1 AGC45774.1 cysC cysC AGC45627.1 AGC45627.1 AGC45598.1 AGC45598.1 AGC45489.1 AGC45489.1 accA accA AGC45172.1 AGC45172.1 AGC45100.1 AGC45100.1 AGC45084.1 AGC45084.1 lipA lipA thiC thiC AGC44823.1 AGC44823.1 AGC44813.1 AGC44813.1 folD folD AGC44517.1 AGC44517.1 accD accD pdhA pdhA AGC44278.1 AGC44278.1 acsA acsA AGC44267.1 AGC44267.1 AGC44055.1 AGC44055.1 cysD cysD AGC43998.1 AGC43998.1 AGC43997.1 AGC43997.1 cysI cysI AGC43835.1 AGC43835.1 AGC43726.1 AGC43726.1 AGC43654.1 AGC43654.1 AGC43581.1 AGC43581.1 AGC43415.1 AGC43415.1 AGC43346.1 AGC43346.1 AGC43325.1 AGC43325.1 AGC43182.1 AGC43182.1 AGC43148.1 AGC43148.1 AGC43029.1 AGC43029.1 AGC43028.1 AGC43028.1 AGC42749.1 AGC42749.1 bioD bioD bioF bioF bioB bioB AGC42507.1 AGC42507.1 AGC42394.1 AGC42394.1 AGC42368.1 AGC42368.1 AGC42340.1 AGC42340.1 AGC42262.1 AGC42262.1 AGC41898.1 AGC41898.1 AGC41804.1 AGC41804.1 AGC41674.1 AGC41674.1 AGC41436.1 AGC41436.1 gshB gshB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGC43583.1Hypothetical protein. (363 aa)
AGC49351.1Hexapeptide repeat-containing transferase. (184 aa)
AGC48585.1Aminotransferase, class V/cysteine desulfurase. (141 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (316 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (392 aa)
mtnP5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (294 aa)
mtnAMethylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (368 aa)
AGC48045.1Hypothetical protein. (270 aa)
AGC48043.1Hypothetical protein. (828 aa)
AGC47829.1Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (295 aa)
metXAPutative homoserine-O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (434 aa)
acsA-2acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa)
AGC47672.1Hypothetical protein. (294 aa)
AGC47671.1Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (430 aa)
AGC47666.1O-acetyltransferase. (146 aa)
AGC47626.1acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (461 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa)
AGC46848.1Phosphomethylpyrimidine kinase. (246 aa)
AGC46716.1Hypothetical protein. (186 aa)
AGC46574.1Phosphomethylpyrimidine kinase. (274 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (583 aa)
AGC46307.12-oxoisovalerate dehydrogenase complex, E1 component subunit alpha. (335 aa)
AGC46276.1Hypothetical protein. (227 aa)
folD-2Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa)
AGC45975.1Hexapeptide repeat-containing transferase. (172 aa)
AGC45969.1Putative thiamine-phosphate pyrophosphorylase. (211 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (260 aa)
AGC45967.1Thiamine biosynthesis protein ThiS. (66 aa)
AGC45885.1Glyoxalase. (154 aa)
AGC45775.1Sulfate adenylyltransferase subunit 2. (316 aa)
AGC45774.1Sulfate adenylyltransferase large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (418 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (185 aa)
AGC45627.1Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase subunit alpha. (344 aa)
AGC45598.12-amino-3-ketobutyrate coenzyme A ligase. (404 aa)
AGC45489.1Class II aminotransferase. (515 aa)
accAacetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa)
AGC45172.1Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (260 aa)
AGC45100.1Alpha/beta fold family hydrolase; Belongs to the AB hydrolase superfamily. MetX family. (344 aa)
AGC45084.1Cysteine synthase A. (334 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (309 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (624 aa)
AGC44823.1Aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (363 aa)
AGC44813.15,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (290 aa)
folDMethylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
AGC44517.1Hypothetical protein. (246 aa)
accDacetyl-CoA carboxylase, carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa)
pdhAPyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (379 aa)
AGC44278.1Class II aminotransferase. (451 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa)
AGC44267.1Semialdehyde dehydrogenase family protein; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
AGC44055.1Hypothetical protein. (236 aa)
cysDSulfate adenylyltransferase subunit 2. (305 aa)
AGC43998.1Sulfate adenylyltransferase large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (577 aa)
AGC43997.1Sulfite reductase [NADPH] flavoprotein, alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (619 aa)
cysISulfite reductase subunit beta; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (563 aa)
AGC43835.12-amino-3-ketobutyrate coenzyme A ligase. (410 aa)
AGC43726.1Glyoxalase family protein. (134 aa)
AGC43654.1Cystathionine beta-synthase. (456 aa)
AGC43581.15-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1171 aa)
AGC43415.1Glyoxalase/bleomycin resistance protein/dioxygenase. (134 aa)
AGC43346.1Glyoxalase/bleomycin resistance protein/dioxygenase. (138 aa)
AGC43325.1Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (543 aa)
AGC43182.18-amino-7-oxononanoate synthase. (363 aa)
AGC43148.1Glyoxalase/bleomycin resistance protein/dioxygenase. (133 aa)
AGC43029.1Putative serine O-acetyltransferase. (281 aa)
AGC43028.1Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (307 aa)
AGC42749.1Gamma-glutamyltransferase. (600 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (225 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (403 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (344 aa)
AGC42507.1propionyl-CoA carboxylase subunit alpha; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (508 aa)
AGC42394.1Cysteine synthase. (322 aa)
AGC42368.1Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
AGC42340.1AMP-binding protein. (548 aa)
AGC42262.1MerR family transcriptional regulator. (288 aa)
AGC41898.1Hypothetical protein. (396 aa)
AGC41804.1Hypothetical protein. (216 aa)
AGC41674.1Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa)
AGC41436.1acetyl-CoA carboxylase biotin carboxylase subunit. (662 aa)
gshBGlutathione synthase; Belongs to the prokaryotic GSH synthase family. (322 aa)
Your Current Organism:
Myxococcus stipitatus
NCBI taxonomy Id: 1278073
Other names: M. stipitatus DSM 14675, Myxococcus stipitatus DSM 14675
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