STRINGSTRING
rlmN-2 rlmN-2 AGC49051.1 AGC49051.1 AGC48341.1 AGC48341.1 AGC48196.1 AGC48196.1 AGC48189.1 AGC48189.1 AGC48142.1 AGC48142.1 tal-2 tal-2 AGC48067.1 AGC48067.1 trpA trpA trpF trpF trpC trpC AGC47958.1 AGC47958.1 AGC47832.1 AGC47832.1 dapA dapA tal tal pyrF pyrF deoC deoC AGC47296.1 AGC47296.1 thiE thiE fni fni AGC46442.1 AGC46442.1 AGC46441.1 AGC46441.1 AGC46233.1 AGC46233.1 AGC46162.1 AGC46162.1 pdxJ pdxJ AGC46113.1 AGC46113.1 AGC46098.1 AGC46098.1 AGC46089.1 AGC46089.1 AGC46087.1 AGC46087.1 AGC46019.1 AGC46019.1 AGC45969.1 AGC45969.1 thiG thiG AGC45841.1 AGC45841.1 AGC45742.1 AGC45742.1 AGC45608.1 AGC45608.1 AGC45484.1 AGC45484.1 guaB guaB AGC45348.1 AGC45348.1 AGC45339.1 AGC45339.1 AGC45275.1 AGC45275.1 AGC45130.1 AGC45130.1 AGC45113.1 AGC45113.1 lipA lipA hisF hisF hisA hisA moaA moaA pyrD pyrD AGC44685.1 AGC44685.1 AGC44670.1 AGC44670.1 AGC44669.1 AGC44669.1 tpiA tpiA AGC44003.1 AGC44003.1 dusA dusA AGC43444.1 AGC43444.1 AGC43381.1 AGC43381.1 AGC43368.1 AGC43368.1 rlmN rlmN bioB bioB AGC42486.1 AGC42486.1 AGC42144.1 AGC42144.1 AGC41854.1 AGC41854.1 queE queE AGC41656.1 AGC41656.1 AGC41395.1 AGC41395.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rlmN-2Radical SAM protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (379 aa)
AGC49051.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (446 aa)
AGC48341.1Ribosomal RNA large subunit methyltransferase N; Belongs to the radical SAM superfamily. RlmN family. (353 aa)
AGC48196.1Putative tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (338 aa)
AGC48189.1Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa)
AGC48142.1NADH:flavin oxidoreductase. (351 aa)
tal-2Transaldolase family protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (373 aa)
AGC48067.12-nitropropane dioxygenase. (362 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (212 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (273 aa)
AGC47958.1Phospho-2-dehydro-3-deoxyheptonate aldolase. (341 aa)
AGC47832.1Hypothetical protein. (492 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa)
talPutative translaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (284 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (279 aa)
AGC47296.1FAD/FMN-binding oxidoreductase. (358 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa)
fniIsopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (352 aa)
AGC46442.1L-lysine 2,3-aminomutase. (456 aa)
AGC46441.1L-lysine 2,3-aminomutase. (415 aa)
AGC46233.1Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (292 aa)
AGC46162.1Hypothetical protein. (275 aa)
pdxJPyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (241 aa)
AGC46113.12-nitropropane dioxygenase. (394 aa)
AGC46098.1Radical SAM domain-containing protein. (447 aa)
AGC46089.1Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (465 aa)
AGC46087.1Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (457 aa)
AGC46019.1Phospho-2-dehydro-3-deoxyheptonate aldolase. (372 aa)
AGC45969.1Putative thiamine-phosphate pyrophosphorylase. (211 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (260 aa)
AGC45841.1Hypothetical protein. (345 aa)
AGC45742.1Phospho-2-dehydro-3-deoxyheptonate aldolase. (301 aa)
AGC45608.13-deoxy-7-phosphoheptulonate synthase. (457 aa)
AGC45484.1hydroxymethylglutaryl-CoA lyase. (324 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa)
AGC45348.1propionyl-CoA carboxylase subunit alpha; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1167 aa)
AGC45339.1FAD/FMN-binding oxidoreductase. (417 aa)
AGC45275.1Glutamate synthase large subunit. (1518 aa)
AGC45130.1Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (335 aa)
AGC45113.1Radical SAM domain-containing protein. (434 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (309 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (238 aa)
moaAMolybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (336 aa)
pyrDDihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (364 aa)
AGC44685.1Radical SAM domain-containing protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (218 aa)
AGC44670.1Radical SAM domain-containing protein. (295 aa)
AGC44669.1Coproporphyrinogen III oxidase. (438 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa)
AGC44003.1(S)-2-hydroxy-acid oxidase. (407 aa)
dusAtRNA-dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (332 aa)
AGC43444.1NADH:flavin oxidoreductase. (357 aa)
AGC43381.1Hypothetical protein. (427 aa)
AGC43368.1Heme biosynthesis protein. (332 aa)
rlmNRadical SAM protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (360 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (344 aa)
AGC42486.12-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (280 aa)
AGC42144.1Dihydrodipicolinate synthase; Belongs to the DapA family. (296 aa)
AGC41854.12-nitropropane dioxygenase. (400 aa)
queERadical SAM domain-containing protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (230 aa)
AGC41656.1Radical SAM domain-containing protein. (263 aa)
AGC41395.1Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (364 aa)
Your Current Organism:
Myxococcus stipitatus
NCBI taxonomy Id: 1278073
Other names: M. stipitatus DSM 14675, Myxococcus stipitatus DSM 14675
Server load: low (18%) [HD]