(22 nodes) Pantothenate and CoA biosynthesis network (Myxococcus stipitatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AGC41981.1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (479 aa)
	AGC41982.1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (484 aa)
	AGC43047.1	Class IV aminotransferase. (274 aa)
	panB	3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (309 aa)
	panC	Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa)
	AGC43905.1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (510 aa)
	coaA	Pantothenate kinase. (316 aa)
	AGC44635.1	Acetolactate synthase; Belongs to the TPP enzyme family. (548 aa)
	ilvE	Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (315 aa)
	coaE	dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa)
	AGC44910.1	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (318 aa)
	coaX	Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (256 aa)
	AGC45777.1	4'-phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (242 aa)
	coaD	Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
	AGC46073.1	HetI protein; Belongs to the P-Pant transferase superfamily. (286 aa)
	acpS	Holo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (126 aa)
	AGC46172.1	Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (410 aa)
	AGC46480.1	MazG family protein. (417 aa)
	AGC47053.1	Acetolactate synthase. (579 aa)
	coaD-2	Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (165 aa)
	AGC47495.1	2-aminomuconic semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (496 aa)
	panD	Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (130 aa)

Your Current Organism:

Myxococcus stipitatus

NCBI taxonomy Id: 1278073
Other names: M. stipitatus DSM 14675, Myxococcus stipitatus DSM 14675

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGC41981.1	AGC41982.1	MYSTI_00631	MYSTI_00632	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.626
AGC41981.1	AGC46073.1	MYSTI_00631	MYSTI_04783	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	HetI protein; Belongs to the P-Pant transferase superfamily.	0.476
AGC41981.1	panC	MYSTI_00631	MYSTI_02351	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.	0.902
AGC41981.1	panD	MYSTI_00631	MYSTI_07428	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.	0.906
AGC41982.1	AGC41981.1	MYSTI_00632	MYSTI_00631	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.626
AGC41982.1	AGC46073.1	MYSTI_00632	MYSTI_04783	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	HetI protein; Belongs to the P-Pant transferase superfamily.	0.476
AGC41982.1	panC	MYSTI_00632	MYSTI_02351	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.	0.902
AGC41982.1	panD	MYSTI_00632	MYSTI_07428	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.	0.906
AGC43047.1	AGC44635.1	MYSTI_01715	MYSTI_03323	Class IV aminotransferase.	Acetolactate synthase; Belongs to the TPP enzyme family.	0.558
AGC43047.1	AGC46073.1	MYSTI_01715	MYSTI_04783	Class IV aminotransferase.	HetI protein; Belongs to the P-Pant transferase superfamily.	0.532
AGC43047.1	AGC47053.1	MYSTI_01715	MYSTI_05777	Class IV aminotransferase.	Acetolactate synthase.	0.558
AGC43047.1	ilvE	MYSTI_01715	MYSTI_03447	Class IV aminotransferase.	Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.900
AGC43047.1	panB	MYSTI_01715	MYSTI_02350	Class IV aminotransferase.	3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.	0.920
AGC43905.1	AGC46073.1	MYSTI_02589	MYSTI_04783	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	HetI protein; Belongs to the P-Pant transferase superfamily.	0.476
AGC43905.1	panC	MYSTI_02589	MYSTI_02351	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.	0.902
AGC43905.1	panD	MYSTI_02589	MYSTI_07428	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.	0.906
AGC44635.1	AGC43047.1	MYSTI_03323	MYSTI_01715	Acetolactate synthase; Belongs to the TPP enzyme family.	Class IV aminotransferase.	0.558
AGC44635.1	AGC46073.1	MYSTI_03323	MYSTI_04783	Acetolactate synthase; Belongs to the TPP enzyme family.	HetI protein; Belongs to the P-Pant transferase superfamily.	0.580
AGC44635.1	AGC47053.1	MYSTI_03323	MYSTI_05777	Acetolactate synthase; Belongs to the TPP enzyme family.	Acetolactate synthase.	0.918
AGC44635.1	ilvE	MYSTI_03323	MYSTI_03447	Acetolactate synthase; Belongs to the TPP enzyme family.	Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.604