STRINGSTRING
AGC41395.1 AGC41395.1 AGC41655.1 AGC41655.1 AGC41788.1 AGC41788.1 AGC41870.1 AGC41870.1 AGC42274.1 AGC42274.1 AGC42368.1 AGC42368.1 AGC42369.1 AGC42369.1 AGC42370.1 AGC42370.1 AGC42371.1 AGC42371.1 AGC42394.1 AGC42394.1 AGC42411.1 AGC42411.1 AGC42480.1 AGC42480.1 gpmI gpmI AGC42631.1 AGC42631.1 AGC42711.1 AGC42711.1 AGC42712.1 AGC42712.1 argC argC AGC42716.1 AGC42716.1 AGC42717.1 AGC42717.1 AGC42718.1 AGC42718.1 proB proB AGC42731.1 AGC42731.1 AGC42767.1 AGC42767.1 AGC42800.1 AGC42800.1 AGC43013.1 AGC43013.1 AGC43028.1 AGC43028.1 AGC43029.1 AGC43029.1 AGC43047.1 AGC43047.1 AGC43147.1 AGC43147.1 AGC43491.1 AGC43491.1 AGC43569.1 AGC43569.1 AGC43581.1 AGC43581.1 AGC43647.1 AGC43647.1 AGC43654.1 AGC43654.1 AGC43831.1 AGC43831.1 AGC43941.1 AGC43941.1 AGC43952.1 AGC43952.1 AGC44043.1 AGC44043.1 AGC44077.1 AGC44077.1 thrB thrB AGC44267.1 AGC44267.1 AGC44279.1 AGC44279.1 AGC44517.1 AGC44517.1 AGC44527.1 AGC44527.1 AGC44551.1 AGC44551.1 tpiA tpiA AGC44573.1 AGC44573.1 AGC44635.1 AGC44635.1 ilvE ilvE argD argD AGC44823.1 AGC44823.1 hisG hisG hisD hisD AGC45028.1 AGC45028.1 AGC45029.1 AGC45029.1 hisA hisA AGC45031.1 AGC45031.1 hisF hisF hisI hisI AGC45084.1 AGC45084.1 hisC hisC pfkA pfkA AGC45274.1 AGC45274.1 AGC45275.1 AGC45275.1 AGC45348.1 AGC45348.1 AGC45486.1 AGC45486.1 AGC45584.1 AGC45584.1 AGC45608.1 AGC45608.1 AGC45730.1 AGC45730.1 AGC45742.1 AGC45742.1 AGC45744.1 AGC45744.1 aroC aroC AGC45747.1 AGC45747.1 AGC45748.1 AGC45748.1 AGC45749.1 AGC45749.1 AGC45753.1 AGC45753.1 AGC45799.1 AGC45799.1 AGC45812.1 AGC45812.1 AGC45838.1 AGC45838.1 AGC45975.1 AGC45975.1 AGC46017.1 AGC46017.1 pheA pheA AGC46019.1 AGC46019.1 eno eno glyA glyA AGC46506.1 AGC46506.1 AGC46639.1 AGC46639.1 serC serC dapF dapF prs prs AGC46870.1 AGC46870.1 argB argB AGC46872.1 AGC46872.1 argH argH AGC46874.1 AGC46874.1 argC-2 argC-2 AGC46894.1 AGC46894.1 AGC47053.1 AGC47053.1 rpiA rpiA gpmA gpmA AGC47494.1 AGC47494.1 AGC47666.1 AGC47666.1 AGC47761.1 AGC47761.1 metXA metXA tal tal dapB dapB dapA dapA lysA lysA AGC47958.1 AGC47958.1 trpD trpD trpC trpC trpF trpF trpB trpB trpA trpA AGC47966.1 AGC47966.1 AGC47967.1 AGC47967.1 AGC48031.1 AGC48031.1 tal-2 tal-2 AGC48106.1 AGC48106.1 AGC48189.1 AGC48189.1 AGC48191.1 AGC48191.1 AGC48230.1 AGC48230.1 AGC48248.1 AGC48248.1 pfkA-2 pfkA-2 metK metK AGC48659.1 AGC48659.1 AGC48663.1 AGC48663.1 AGC49021.1 AGC49021.1 AGC49281.1 AGC49281.1 AGC49351.1 AGC49351.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGC41395.1Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (364 aa)
AGC41655.1Putative asparagine synthetase. (438 aa)
AGC41788.1Citrate synthase. (410 aa)
AGC41870.1Class I aminotransferase. (432 aa)
AGC42274.1Glutamate--ammonia ligase; Belongs to the glutamine synthetase family. (479 aa)
AGC42368.1Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
AGC42369.1Cys/Met metabolism PLP-dependent enzyme. (352 aa)
AGC42370.1Cys/Met metabolism PLP-dependent enzyme. (375 aa)
AGC42371.1Aspartate kinase. (833 aa)
AGC42394.1Cysteine synthase. (322 aa)
AGC42411.1Acetylornithine deacetylase. (378 aa)
AGC42480.1ACT domain-containing protein/phosphoserine phosphatase SerB. (397 aa)
gpmIPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (513 aa)
AGC42631.1Class I/II aminotransferase. (389 aa)
AGC42711.1Acetyl-lysine deacetylase. (356 aa)
AGC42712.1Acetylglutamate kinase. (285 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
AGC42716.1alpha-aminoadipate--lysW ligase lysX; Belongs to the RimK family. (280 aa)
AGC42717.1Transketolase. (345 aa)
AGC42718.1Transketolase. (269 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (375 aa)
AGC42731.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (909 aa)
AGC42767.13-dehydroquinate dehydratase. (302 aa)
AGC42800.1L-allo-threonine aldolase. (341 aa)
AGC43013.1Class I aminotransferase. (422 aa)
AGC43028.1Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (307 aa)
AGC43029.1Putative serine O-acetyltransferase. (281 aa)
AGC43047.1Class IV aminotransferase. (274 aa)
AGC43147.1Histidinol-phosphate aminotransferase. (377 aa)
AGC43491.1Threonine dehydratase. (306 aa)
AGC43569.1Cys/Met metabolism PLP-dependent enzyme. (394 aa)
AGC43581.15-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1171 aa)
AGC43647.1Cys/Met metabolism PLP-dependent enzyme. (381 aa)
AGC43654.1Cystathionine beta-synthase. (456 aa)
AGC43831.1Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa)
AGC43941.1Aspartate kinase. (818 aa)
AGC43952.1Arginase/agmatinase/formiminoglutamase; Belongs to the arginase family. (309 aa)
AGC44043.1Diaminopimelate decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (489 aa)
AGC44077.16-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (312 aa)
thrBHomoserine kinase; Belongs to the pseudomonas-type ThrB family. (323 aa)
AGC44267.1Semialdehyde dehydrogenase family protein; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
AGC44279.1Alpha-ribazole-5'-phosphate phosphatase; Belongs to the phosphoglycerate mutase family. (209 aa)
AGC44517.1Hypothetical protein. (246 aa)
AGC44527.1Asparagine synthase. (655 aa)
AGC44551.1Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa)
AGC44573.1Phage prohead protease. (222 aa)
AGC44635.1Acetolactate synthase; Belongs to the TPP enzyme family. (548 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (315 aa)
argDAcetylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (412 aa)
AGC44823.1Aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (363 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (286 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa)
AGC45028.1Histidinol-phosphate aminotransferase. (346 aa)
AGC45029.1Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit. (197 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (238 aa)
AGC45031.1Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family. (180 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa)
hisIphosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase; In the N-terminal section; belongs to the PRA-CH family. (209 aa)
AGC45084.1Cysteine synthase A. (334 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (363 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (365 aa)
AGC45274.1Glutamate synthase small subunit. (486 aa)
AGC45275.1Glutamate synthase large subunit. (1518 aa)
AGC45348.1propionyl-CoA carboxylase subunit alpha; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1167 aa)
AGC45486.1Class I/II aminotransferase. (397 aa)
AGC45584.1Aspartate aminotransferase. (557 aa)
AGC45608.13-deoxy-7-phosphoheptulonate synthase. (457 aa)
AGC45730.1Isocitrate dehydrogenase. (432 aa)
AGC45742.1Phospho-2-dehydro-3-deoxyheptonate aldolase. (301 aa)
AGC45744.1Putative shikimate kinase. (154 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (339 aa)
AGC45747.13-dehydroquinate synthase. (356 aa)
AGC45748.13-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (429 aa)
AGC45749.1Citrate synthase; Belongs to the citrate synthase family. (433 aa)
AGC45753.1Pyruvate kinase; Belongs to the pyruvate kinase family. (466 aa)
AGC45799.1Aspartate kinase; Belongs to the aspartokinase family. (428 aa)
AGC45812.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (445 aa)
AGC45838.1Putative aspartate aminotransferase. (396 aa)
AGC45975.1Hexapeptide repeat-containing transferase. (172 aa)
AGC46017.1Chorismate mutase. (379 aa)
pheAPrephenate dehydratase. (274 aa)
AGC46019.1Phospho-2-dehydro-3-deoxyheptonate aldolase. (372 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
AGC46506.1Ribose 5-phosphate isomerase B. (147 aa)
AGC46639.1Aspartate kinase; Belongs to the aspartokinase family. (397 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (283 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa)
AGC46870.1N-acetylornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (336 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (308 aa)
AGC46872.1M20A family peptidase. (353 aa)
argHArgininosuccinate lyase. (454 aa)
AGC46874.1Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (397 aa)
argC-2N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (355 aa)
AGC46894.1Phenylalanine 4-monooxygenase. (524 aa)
AGC47053.1Acetolactate synthase. (579 aa)
rpiARibose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (237 aa)
gpmA2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (202 aa)
AGC47494.1Glutamine synthetase. (488 aa)
AGC47666.1O-acetyltransferase. (146 aa)
AGC47761.1Threonine dehydratase. (405 aa)
metXAPutative homoserine-O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (434 aa)
talPutative translaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (271 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa)
AGC47958.1Phospho-2-dehydro-3-deoxyheptonate aldolase. (341 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (273 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (212 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (401 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa)
AGC47966.1Anthranilate synthase, glutamine amidotransferase component. (187 aa)
AGC47967.1Putative anthranilate synthase, component I. (499 aa)
AGC48031.1L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (470 aa)
tal-2Transaldolase family protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (373 aa)
AGC48106.1Transketolase. (633 aa)
AGC48189.1Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa)
AGC48191.1Pyruvate kinase; Belongs to the pyruvate kinase family. (459 aa)
AGC48230.1Putative isocitrate dehydrogenase, NAD-dependent. (334 aa)
AGC48248.1D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (417 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (345 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (392 aa)
AGC48659.1Succinyl-diaminopimelate desuccinylase. (361 aa)
AGC48663.12,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (274 aa)
AGC49021.1Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (298 aa)
AGC49281.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (685 aa)
AGC49351.1Hexapeptide repeat-containing transferase. (184 aa)
Your Current Organism:
Myxococcus stipitatus
NCBI taxonomy Id: 1278073
Other names: M. stipitatus DSM 14675, Myxococcus stipitatus DSM 14675
Server load: low (36%) [HD]