(71 nodes) Endonuclease activity network (Fusarium fujikuroi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FFUJ_14224	Uncharacterized protein. (274 aa)
	FFUJ_01690	Related to tRNA-splicing endonuclease. (451 aa)
	FFUJ_01904	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (728 aa)
	FFUJ_01912	ERCC4 domain-containing protein. (676 aa)
	FFUJ_01653	Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (343 aa)
	FFUJ_01714	Related to ribonuclease P protein subunit p30. (297 aa)
	FFUJ_01089	Uncharacterized protein. (87 aa)
	FFUJ_00722	Related to RAD13. (1232 aa)
	FFUJ_00855	Related to argonaute like post-transcriptional gene silencing protein QDE-2; Belongs to the argonaute family. (988 aa)
	FFUJ_00796	Related to BRR5-component of pre-mRNA polyadenylation factor PF I. (832 aa)
	FFUJ_00780	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (339 aa)
	SLX4	Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (890 aa)
	FFUJ_00160	TY3B-TY3B protein. (2189 aa)
	FFUJ_00077	Protein kinase domain-containing protein. (264 aa)
	FFUJ_05236	Uncharacterized protein. (161 aa)
	FFUJ_00804	Related to lariat-debranching enzyme. (553 aa)
	FFUJ_01322	Related to MUS81 protein, repair of UV-and methylation-induced DNA damage. (582 aa)
	FFUJ_01289	Related to RNA 3`-terminal phosphate cyclase-like protein. (387 aa)
	FFUJ_04573	Uncharacterized protein. (661 aa)
	FFUJ_04538	Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (177 aa)
	FFUJ_04385	Uncharacterized protein. (420 aa)
	FFUJ_04375	Related to DNA helicase. (1578 aa)
	FFUJ_04278	Uncharacterized protein. (160 aa)
	FFUJ_04159	Uncharacterized protein. (531 aa)
	FFUJ_04152	Related to switching protein SWI10. (386 aa)
	FFUJ_04238	Related to translin-associated protein X. (260 aa)
	FFUJ_04714	Uncharacterized protein. (231 aa)
	FFUJ_02160	Probable nuclease S1. (337 aa)
	FFUJ_02638	Probable FCF1 involved in the pre-rRNA processing steps of 40S ribosomal subunit biogenesis. (198 aa)
	FFUJ_02695	Probable hydroxyacylglutathione hydrolase. (309 aa)
	FFUJ_02694	Uncharacterized protein. (347 aa)
	FFUJ_02798	Related to Staphylococcus aureus nuclease (SNase). (268 aa)
	FFUJ_02807	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (828 aa)
	FFUJ_05297	Probable IRE1-protein kinase. (1255 aa)
	FFUJ_03298	Endonuclease. (346 aa)
	FFUJ_02810	Probable EXO1-exonuclease which interacts with Msh2p. (744 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (319 aa)
	FFUJ_13469	Related to Ribonuclease III. (344 aa)
	FFUJ_13712	Uncharacterized protein. (205 aa)
	FFUJ_02843	Related to MKT1 protein. (745 aa)
	FFUJ_13143	Related to tRNA-splicing endonuclease beta chain. (608 aa)
	FFUJ_03354	Related to purine nucleotide binding protein. (837 aa)
	FFUJ_07746	Related to ribonucleases; Belongs to the RNase T2 family. (278 aa)
	FFUJ_07028	Uncharacterized protein. (323 aa)
	FFUJ_06007	Uncharacterized protein. (393 aa)
	FFUJ_06175	Uncharacterized protein. (192 aa)
	FFUJ_06151	Related to ribonuclease P chain POP1. (904 aa)
	FFUJ_08936	Related to Sms-3 endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1500 aa)
	FFUJ_07614	Uncharacterized protein. (284 aa)
	FFUJ_08593	Uncharacterized protein. (239 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
	FFUJ_14021	Uncharacterized protein. (414 aa)
	FFUJ_12301	Related to ribosomal protein YmL3. (383 aa)
	FFUJ_06154	Probable MUS-38 protein, involved in nucleotide excision repair. (937 aa)
	FFUJ_06303	Probable argonaute like post-transcriptional gene silencing protein QDE-2. (1063 aa)
	FFUJ_12581	RNase H domain-containing protein. (281 aa)
	FFUJ_06580	Probable argonaute like post-transcriptional gene silencing protein QDE-2. (1022 aa)
	FFUJ_12455	Probable pectate lyase 1. (324 aa)
	FFUJ_05686	Related to APN2-AP endonuclease, exonuclease III homolog. (601 aa)
	FFUJ_09099	20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (448 aa)
	FFUJ_08987	Probable UV-endonuclease UVE-1. (611 aa)
	FFUJ_08976	Uncharacterized protein. (441 aa)
	FFUJ_10229	Zn(2)-C6 fungal-type domain-containing protein. (597 aa)
	FFUJ_09877	Related to Dcl-2 dicer RNA helicase/RNAseIII CAF; Belongs to the helicase family. Dicer subfamily. (1457 aa)
	FFUJ_09430	Probable vegetatible incompatibility protein HET-E-1. (1433 aa)
	FFUJ_11196	Uncharacterized protein. (130 aa)
	FFUJ_09854	Related to DNA repair endonuclease rad2. (794 aa)
	FFUJ_11552	Related to ribonucleases; Belongs to the RNase T2 family. (263 aa)
	FFUJ_09733	tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (284 aa)
	FFUJ_14185	Uncharacterized protein. (356 aa)
	FFUJ_14239	Uncharacterized protein. (275 aa)

Your Current Organism:

Fusarium fujikuroi

NCBI taxonomy Id: 1279085
Other names: F. fujikuroi IMI 58289, Fusarium fujikuroi IMI 58289, Fusarium fujikuroi IMI58289, Gibberella fujikuroi IMI 58289

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	FFUJ_00722	S0EA48	S0DJI0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Related to RAD13.	0.649
FEN1	FFUJ_00780	S0EA48	S0DJU9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.796
FEN1	FFUJ_01322	S0EA48	S0DNK4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Related to MUS81 protein, repair of UV-and methylation-induced DNA damage.	0.932
FEN1	FFUJ_01653	S0EA48	S0DI76	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.597
FEN1	FFUJ_01904	S0EA48	S0DHV2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.984
FEN1	FFUJ_01912	S0EA48	S0DHX1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ERCC4 domain-containing protein.	0.560
FEN1	FFUJ_02810	S0EA48	S0DW29	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Probable EXO1-exonuclease which interacts with Msh2p.	0.918
FEN1	FFUJ_03298	S0EA48	S0DUK9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Endonuclease.	0.727
FEN1	FFUJ_04152	S0EA48	S0DQ86	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Related to switching protein SWI10.	0.857
FEN1	FFUJ_04375	S0EA48	S0DPN2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Related to DNA helicase.	0.981
FEN1	FFUJ_04385	S0EA48	S0DPM4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.583
FEN1	FFUJ_04573	S0EA48	S0DNR1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.438
FEN1	FFUJ_05686	S0EA48	S0EEA4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Related to APN2-AP endonuclease, exonuclease III homolog.	0.961
FEN1	FFUJ_06154	S0EA48	S0ECT6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Probable MUS-38 protein, involved in nucleotide excision repair.	0.899
FEN1	FFUJ_08987	S0EA48	S0EF32	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Probable UV-endonuclease UVE-1.	0.521
FEN1	FFUJ_09430	S0EA48	S0EIQ5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Probable vegetatible incompatibility protein HET-E-1.	0.438
FEN1	FFUJ_09854	S0EA48	S0EJS6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Related to DNA repair endonuclease rad2.	0.799
FEN1	FFUJ_11196	S0EA48	S0EJD9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.592
FEN1	FFUJ_12581	S0EA48	S0EDI4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	RNase H domain-containing protein.	0.594
FEN1	FFUJ_13712	S0EA48	S0DY85	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.594