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FFUJ_09241 FFUJ_09241 GPY1 GPY1 FFUJ_12066 FFUJ_12066 FFUJ_11034 FFUJ_11034 FFUJ_11199 FFUJ_11199 FFUJ_10347 FFUJ_10347 FFUJ_12757 FFUJ_12757 FUS1 FUS1 FFUJ_09697 FFUJ_09697 PKS19 PKS19 FFUJ_12707 FFUJ_12707 FFUJ_12539 FFUJ_12539 FFUJ_08348 FFUJ_08348 FFUJ_06366 FFUJ_06366 FFUJ_06260 FFUJ_06260 FFUJ_14695 FFUJ_14695 FFUJ_05866 FFUJ_05866 FFUJ_04145 FFUJ_04145 FFUJ_04370 FFUJ_04370 FUB1 FUB1 PKS-NRPS1 PKS-NRPS1 FSR1 FSR1 FFUJ_03235 FFUJ_03235 FFUJ_04089 FFUJ_04089 bik1 bik1 apf5 apf5 FFUJ_00118 FFUJ_00118 FFUJ_06831 FFUJ_06831 FFUJ_05034 FFUJ_05034 FFUJ_04562 FFUJ_04562 FFUJ_12074 FFUJ_12074
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
FFUJ_09241Fumonisin cluster-polyketide synthase. (2580 aa)
GPY1Highly reducing polyketide synthase GPY1; Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of gibepyrone A, a 2H-pyran-2-one metabolite exhibiting a moderate antimicrobial activity against Gram- positive bacteria and yeasts. The highly reducing polyketide synthase GPY1 is sufficient to produce gibepyrone A. GPY1 uses an acetyl-CoA starter unit, three malonyl-CoA extender units, and two SAM-dependent methylations to establish the gibepyrone A carbon backbone, followed by product release upon intramolecular cyclization. The gibepyrone A derivat [...] (2543 aa)
FFUJ_12066Probable type I polyketide synthase. (2591 aa)
FFUJ_11034Probable polyketide synthase. (2386 aa)
FFUJ_11199Probable type I polyketide synthase. (2649 aa)
FFUJ_10347Polyketide synthase. (2484 aa)
FFUJ_12757Probable sterol carrier protein; Belongs to the thiolase-like superfamily. Thiolase family. (463 aa)
FUS1Fusarin C synthetase; Fusarin C synthetase; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C. Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production. The roles of the other FUS members are yet undetermined. The fusarin C synthetase FUS1 is responsible for the condensation of one acetyl-coenzyme A (CoA) unit with six malonyl-CoA units and the amide linkage of the arising heptaketide and homoserine, subsequently releasing the first intermediate, prefusarin, as an alcohol with an open ring structure. The cytochrome P450 monoox [...] (3916 aa)
FFUJ_09697Probable POT1-acetyl-CoA C-acyltransferase, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. (416 aa)
PKS19Polyketide synthase 19; Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fujikurins A-D, secondary metabolites playing a role during rice infection. The polyketide synthase PKS19 acts with the trans- enoyl reductase FFUJ_12240 and the polyketide transferase FFUJ_12241 to produce fujikurins, however, the biosynthesis pathway has not been identified yet. (2492 aa)
FFUJ_12707Probable polyketide synthase. (3935 aa)
FFUJ_12539Probable acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (410 aa)
FFUJ_08348Probable sterol carrier protein; Belongs to the thiolase-like superfamily. Thiolase family. (458 aa)
FFUJ_06366Probable acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (417 aa)
FFUJ_06260Polyketide synthase. (2351 aa)
FFUJ_14695Related to polyketide synthase. (4090 aa)
FFUJ_05866Related to stilbene synthase 2; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (448 aa)
FFUJ_041453-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (456 aa)
FFUJ_04370Probable Acetyl-CoA acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (418 aa)
FUB1Reducing polyketide synthase FUB1; Reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties. L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism. The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively [...] (2410 aa)
PKS-NRPS1Trichosetin synthetase PKS-NRPS1; Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of trichosetin, a trans-fused decalin- containing tetramic acid with antimicrobial activity. The PKS module of PKS-NRPS1 together with the enoylreductase (ER) catalyze the formation of the polyketide unit which is then conjugated to L-serine by the condensation domain of the PKS-NRPS1 NRPS module (By similarity). Activity of the Dieckmann cyclase domain (RED) results in release of the intermediate N-desmethylequisetin also called trichosetin (By similarity). Diels-Alder [...] (3914 aa)
FSR1Non-reducing polyketide synthase fsr1; Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fusarubins, highly pigmented naphthoquinones responsible for the coloration of the fruiting bodies. The non-reducing polyketide synthase FSR1 is responsible for the condensation of seven acetyl-CoA units to yield a haptaketide. After rings A and B are formed by aldol-type cyclization, the PKS-derived product is released as 6-O-demethylfusarubinaldehyde. Then, two hydroxyl groups at C-5 and C-10 are incorporated by FSR3, and simultaneously hydroxyl groups a [...] (2286 aa)
FFUJ_032353-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (428 aa)
FFUJ_04089Probable acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
bik1Bikaverin polyketide synthase bik1; Polyketide synthase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre- bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 leads t [...] (2036 aa)
apf5Fatty acid synthase apf5; Fatty acid synthase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF). The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L- phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L- 2-aminooctanedioic acid. L-Phenylalanine is the only proteinogenic amino acid directly used by apf1. The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster. Lysine is converted to delta-1-pyrroline-5-carboxylate (P [...] (1606 aa)
FFUJ_00118Polyketide synthase. (2538 aa)
FFUJ_06831Probable acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa)
FFUJ_05034Probable acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (430 aa)
FFUJ_04562Probable fatty acid synthase, alpha subunit; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. (1855 aa)
FFUJ_12074Polyketide synthase. (2248 aa)
Your Current Organism:
Fusarium fujikuroi
NCBI taxonomy Id: 1279085
Other names: F. fujikuroi IMI 58289, Fusarium fujikuroi IMI 58289, Fusarium fujikuroi IMI58289, Gibberella fujikuroi IMI 58289
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