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FFUJ_10721 FFUJ_10721 FFUJ_02022 FFUJ_02022 FFUJ_00118 FFUJ_00118 apf1 apf1 FFUJ_04614 FFUJ_04614 FFUJ_00282 FFUJ_00282 FUB1 FUB1 FFUJ_00126 FFUJ_00126 PKS-NRPS1 PKS-NRPS1 FFUJ_05054 FFUJ_05054 FSR1 FSR1 FFUJ_03602 FFUJ_03602 FFUJ_03641 FFUJ_03641 FFUJ_02913 FFUJ_02913 FUB8 FUB8 FFUJ_03506 FFUJ_03506 FFUJ_06720 FFUJ_06720 bik1 bik1 FFUJ_05347 FFUJ_05347 FFUJ_14695 FFUJ_14695 FFUJ_06260 FFUJ_06260 FFUJ_06929 FFUJ_06929 FFUJ_12707 FFUJ_12707 FFUJ_08113 FFUJ_08113 PKS19 PKS19 FUS1 FUS1 FFUJ_09250 FFUJ_09250 FFUJ_10347 FFUJ_10347 FFUJ_10736 FFUJ_10736 FFUJ_12380 FFUJ_12380 FFUJ_11199 FFUJ_11199 FFUJ_10900 FFUJ_10900 FFUJ_11034 FFUJ_11034 FFUJ_12066 FFUJ_12066 FFUJ_12090 FFUJ_12090 FFUJ_12038 FFUJ_12038 FFUJ_11742 FFUJ_11742 FFUJ_12008 FFUJ_12008 GPY1 GPY1 BEA1 BEA1 FFUJ_09241 FFUJ_09241 FFUJ_12074 FFUJ_12074
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
FFUJ_10721Related to nonribosomal peptide synthetase MxcG. (1206 aa)
FFUJ_02022Non-ribosomal peptide synthetase. (2560 aa)
FFUJ_00118Polyketide synthase. (2538 aa)
apf1Apicidin F synthase; Non-ribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF). The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L- phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L- 2-aminooctanedioic acid. L-Phenylalanine is the only proteinogenic amino acid directly used by apf1. The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster. Lysine is converted to delta-1-pyrroline-5-carbox [...] (5084 aa)
FFUJ_04614Non-ribosomal peptide synthetase. (4834 aa)
FFUJ_00282Related to nonribosomal peptide synthetase. (1075 aa)
FUB1Reducing polyketide synthase FUB1; Reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties. L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism. The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively [...] (2410 aa)
FFUJ_00126Related to nonribosomal peptide synthetase. (1057 aa)
PKS-NRPS1Trichosetin synthetase PKS-NRPS1; Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of trichosetin, a trans-fused decalin- containing tetramic acid with antimicrobial activity. The PKS module of PKS-NRPS1 together with the enoylreductase (ER) catalyze the formation of the polyketide unit which is then conjugated to L-serine by the condensation domain of the PKS-NRPS1 NRPS module (By similarity). Activity of the Dieckmann cyclase domain (RED) results in release of the intermediate N-desmethylequisetin also called trichosetin (By similarity). Diels-Alder [...] (3914 aa)
FFUJ_05054Related to multidrug resistance protein. (1600 aa)
FSR1Non-reducing polyketide synthase fsr1; Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fusarubins, highly pigmented naphthoquinones responsible for the coloration of the fruiting bodies. The non-reducing polyketide synthase FSR1 is responsible for the condensation of seven acetyl-CoA units to yield a haptaketide. After rings A and B are formed by aldol-type cyclization, the PKS-derived product is released as 6-O-demethylfusarubinaldehyde. Then, two hydroxyl groups at C-5 and C-10 are incorporated by FSR3, and simultaneously hydroxyl groups a [...] (2286 aa)
FFUJ_03602Related to coenzyme a synthetase. (1638 aa)
FFUJ_03641AM-toxin synthetase (AMT). (1226 aa)
FFUJ_02913Probable alpha-aminoadipate reductase large subunit. (1167 aa)
FUB8Non-canonical non-ribosomal peptide synthetase FUB8; Non-canonical non-ribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties. L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism. The polyketide synthase (PKS) FUB1 generates the triketide tr [...] (1036 aa)
FFUJ_03506Related to alpha-aminoadipate reductase large subunit. (1284 aa)
FFUJ_06720Related to AM-toxin synthetase (AMT). (994 aa)
bik1Bikaverin polyketide synthase bik1; Polyketide synthase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre- bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 leads t [...] (2036 aa)
FFUJ_05347Related to non-ribosomal peptide synthetase. (1549 aa)
FFUJ_14695Related to polyketide synthase. (4090 aa)
FFUJ_06260Polyketide synthase. (2351 aa)
FFUJ_06929Non-ribosomal peptide synthetase. (2473 aa)
FFUJ_12707Probable polyketide synthase. (3935 aa)
FFUJ_08113Related to non-ribosomal peptide synthetase. (7581 aa)
PKS19Polyketide synthase 19; Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fujikurins A-D, secondary metabolites playing a role during rice infection. The polyketide synthase PKS19 acts with the trans- enoyl reductase FFUJ_12240 and the polyketide transferase FFUJ_12241 to produce fujikurins, however, the biosynthesis pathway has not been identified yet. (2492 aa)
FUS1Fusarin C synthetase; Fusarin C synthetase; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C. Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production. The roles of the other FUS members are yet undetermined. The fusarin C synthetase FUS1 is responsible for the condensation of one acetyl-coenzyme A (CoA) unit with six malonyl-CoA units and the amide linkage of the arising heptaketide and homoserine, subsequently releasing the first intermediate, prefusarin, as an alcohol with an open ring structure. The cytochrome P450 monoox [...] (3916 aa)
FFUJ_09250Fumonisin cluster-peptidsynthase condensation domain. (584 aa)
FFUJ_10347Polyketide synthase. (2484 aa)
FFUJ_10736Related to AM-toxin synthetase (AMT). (2067 aa)
FFUJ_12380Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (132 aa)
FFUJ_11199Probable type I polyketide synthase. (2649 aa)
FFUJ_10900Related to nonribosomal peptide synthetase MxcG. (1085 aa)
FFUJ_11034Probable polyketide synthase. (2386 aa)
FFUJ_12066Probable type I polyketide synthase. (2591 aa)
FFUJ_12090Probable polyketide synthase. (1974 aa)
FFUJ_12038Related to long-chain-fatty-acid-CoA ligase. (1142 aa)
FFUJ_11742annotation not available (1222 aa)
FFUJ_12008Related to non-ribosomal peptide synthetase. (5756 aa)
GPY1Highly reducing polyketide synthase GPY1; Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of gibepyrone A, a 2H-pyran-2-one metabolite exhibiting a moderate antimicrobial activity against Gram- positive bacteria and yeasts. The highly reducing polyketide synthase GPY1 is sufficient to produce gibepyrone A. GPY1 uses an acetyl-CoA starter unit, three malonyl-CoA extender units, and two SAM-dependent methylations to establish the gibepyrone A carbon backbone, followed by product release upon intramolecular cyclization. The gibepyrone A derivat [...] (2543 aa)
BEA1Beauvericin nonribosomal cyclodepsipeptide synthetase BEA1; Beauvericin nonribosomal cyclodepsipeptide synthetase; part of the gene cluster that mediates the biosynthesis of beauvericin (BEA), a non-ribosomal cyclic hexadepsipeptide that shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic activity. Ketoisovalerate reductase BEA2 catalyzes the NADPH- specific reduction of ketoisovaleric acid to hydroxyisovalerate, a precursor for beauvericin biosynthesis (By similarity). The nonribosomal cyclodepsipeptide synthetase BEA1 then catalyzes the f [...] (3135 aa)
FFUJ_09241Fumonisin cluster-polyketide synthase. (2580 aa)
FFUJ_12074Polyketide synthase. (2248 aa)
Your Current Organism:
Fusarium fujikuroi
NCBI taxonomy Id: 1279085
Other names: F. fujikuroi IMI 58289, Fusarium fujikuroi IMI 58289, Fusarium fujikuroi IMI58289, Gibberella fujikuroi IMI 58289
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