STRINGSTRING
FFUJ_02969 FFUJ_02969 FFUJ_02968 FFUJ_02968 FFUJ_04539 FFUJ_04539 FFUJ_03518 FFUJ_03518 FFUJ_03861 FFUJ_03861 FFUJ_13130 FFUJ_13130 FFUJ_03237 FFUJ_03237 FFUJ_02421 FFUJ_02421 FFUJ_14661 FFUJ_14661 FFUJ_04498 FFUJ_04498 FFUJ_14131 FFUJ_14131 FFUJ_12074 FFUJ_12074 FFUJ_09241 FFUJ_09241 GPY1 GPY1 FFUJ_12090 FFUJ_12090 FFUJ_12066 FFUJ_12066 FFUJ_11198 FFUJ_11198 FFUJ_11034 FFUJ_11034 FFUJ_11199 FFUJ_11199 FFUJ_11075 FFUJ_11075 FFUJ_12183 FFUJ_12183 FFUJ_10979 FFUJ_10979 FFUJ_10570 FFUJ_10570 FFUJ_10347 FFUJ_10347 FFUJ_09876 FFUJ_09876 FFUJ_09891 FFUJ_09891 FFUJ_09663 FFUJ_09663 FFUJ_09689 FFUJ_09689 FFUJ_09625 FFUJ_09625 FFUJ_06260 FFUJ_06260 FFUJ_06644 FFUJ_06644 FFUJ_05961 FFUJ_05961 FFUJ_05998 FFUJ_05998 FFUJ_08712 FFUJ_08712 FFUJ_08707 FFUJ_08707 FFUJ_07755 FFUJ_07755 FFUJ_06327 FFUJ_06327 FFUJ_08289 FFUJ_08289 FFUJ_06584 FFUJ_06584 FFUJ_07597 FFUJ_07597 FFUJ_14073 FFUJ_14073 FFUJ_05491 FFUJ_05491 FFUJ_13810 FFUJ_13810 FFUJ_13807 FFUJ_13807 FFUJ_07042 FFUJ_07042 FFUJ_06192 FFUJ_06192 FFUJ_06276 FFUJ_06276 FFUJ_14374 FFUJ_14374 FFUJ_06201 FFUJ_06201 cnxH cnxH FFUJ_06135 FFUJ_06135 FFUJ_14695 FFUJ_14695 FFUJ_05866 FFUJ_05866 FFUJ_05840 FFUJ_05840 FFUJ_14607 FFUJ_14607 FFUJ_07397 FFUJ_07397 FFUJ_13526 FFUJ_13526 FFUJ_13326 FFUJ_13326 FFUJ_08046 FFUJ_08046 FFUJ_07778 FFUJ_07778 FFUJ_02778 FFUJ_02778 FFUJ_07589 FFUJ_07589 FFUJ_07227 FFUJ_07227 FFUJ_03424 FFUJ_03424 FFUJ_07153 FFUJ_07153 FFUJ_07069 FFUJ_07069 FFUJ_07053 FFUJ_07053 FFUJ_13148 FFUJ_13148 bik1 bik1 FFUJ_02540 FFUJ_02540 FFUJ_02603 FFUJ_02603 PKS19 PKS19 FUS1 FUS1 FFUJ_09730 FFUJ_09730 FFUJ_01092 FFUJ_01092 FUS5 FUS5 FFUJ_10084 FFUJ_10084 FFUJ_09973 FFUJ_09973 FFUJ_13793 FFUJ_13793 FFUJ_06562 FFUJ_06562 FFUJ_12707 FFUJ_12707 FFUJ_06128 FFUJ_06128 FFUJ_05814 FFUJ_05814 FFUJ_05783 FFUJ_05783 FFUJ_01842 FFUJ_01842 FFUJ_01236 FFUJ_01236 FFUJ_01091 FFUJ_01091 FFUJ_01266 FFUJ_01266 FFUJ_01220 FFUJ_01220 FFUJ_01280 FFUJ_01280 FFUJ_01079 FFUJ_01079 FFUJ_00935 FFUJ_00935 FFUJ_00905 FFUJ_00905 FFUJ_01926 FFUJ_01926 FFUJ_00675 FFUJ_00675 FFUJ_00559 FFUJ_00559 FFUJ_01490 FFUJ_01490 FFUJ_00108 FFUJ_00108 FFUJ_00359 FFUJ_00359 FFUJ_00233 FFUJ_00233 FFUJ_00118 FFUJ_00118 FFUJ_00104 FFUJ_00104 uba4 uba4 FFUJ_04922 FFUJ_04922 hxB hxB FFUJ_00370 FFUJ_00370 FFUJ_04721 FFUJ_04721 FFUJ_04695 FFUJ_04695 FFUJ_04415 FFUJ_04415 FFUJ_00998 FFUJ_00998 FFUJ_04441 FFUJ_04441 FFUJ_04341 FFUJ_04341 FFUJ_04282 FFUJ_04282 FFUJ_03730 FFUJ_03730 FFUJ_04725 FFUJ_04725 FFUJ_03734 FFUJ_03734 FFUJ_04289 FFUJ_04289 FUB1 FUB1 FFUJ_00109 FFUJ_00109 FUB4 FUB4 PKS-NRPS1 PKS-NRPS1 FFUJ_04516 FFUJ_04516 FFUJ_00560 FFUJ_00560 FFUJ_02407 FFUJ_02407 FFUJ_02689 FFUJ_02689 FFUJ_02716 FFUJ_02716 FSR1 FSR1
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
FFUJ_02969Probable molybdenum cofactor biosynthesis protein 1 B. (199 aa)
FFUJ_02968Probable molybdenum cofactor biosynthesis protein 1 B. (423 aa)
FFUJ_04539Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (671 aa)
FFUJ_03518Flavokinase domain-containing protein. (623 aa)
FFUJ_03861Probable lysosomal cobalamin transporter. (595 aa)
FFUJ_13130Related to phenylcoumaran benzylic ether reductase. (316 aa)
FFUJ_03237Related to DFR1-dihydrofolate reductase; Belongs to the dihydrofolate reductase family. (201 aa)
FFUJ_02421Probable uric acid-xanthine permease. (590 aa)
FFUJ_14661Related to DUF614 domain protein. (176 aa)
FFUJ_04498BTB domain-containing protein. (409 aa)
FFUJ_14131BTB domain-containing protein. (173 aa)
FFUJ_12074Polyketide synthase. (2248 aa)
FFUJ_09241Fumonisin cluster-polyketide synthase. (2580 aa)
GPY1Highly reducing polyketide synthase GPY1; Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of gibepyrone A, a 2H-pyran-2-one metabolite exhibiting a moderate antimicrobial activity against Gram- positive bacteria and yeasts. The highly reducing polyketide synthase GPY1 is sufficient to produce gibepyrone A. GPY1 uses an acetyl-CoA starter unit, three malonyl-CoA extender units, and two SAM-dependent methylations to establish the gibepyrone A carbon backbone, followed by product release upon intramolecular cyclization. The gibepyrone A derivat [...] (2543 aa)
FFUJ_12090Probable polyketide synthase. (1974 aa)
FFUJ_12066Probable type I polyketide synthase. (2591 aa)
FFUJ_11198FSH1 domain-containing protein. (253 aa)
FFUJ_11034Probable polyketide synthase. (2386 aa)
FFUJ_11199Probable type I polyketide synthase. (2649 aa)
FFUJ_11075APH domain-containing protein. (285 aa)
FFUJ_12183Related to methionine synthase reductase. (616 aa)
FFUJ_10979BPL_N domain-containing protein. (250 aa)
FFUJ_10570Related to C6 transcription factor. (657 aa)
FFUJ_10347Polyketide synthase. (2484 aa)
FFUJ_09876Related to M.pneumoniae uridine kinase udk. (250 aa)
FFUJ_09891Related to thiamin pyrophosphokinase. (313 aa)
FFUJ_09663Related to glutathione transferase omega 1; Belongs to the GST superfamily. (280 aa)
FFUJ_09689Related to 5`-nucleotidase; Belongs to the 5'-nucleotidase family. (675 aa)
FFUJ_09625Related to LRP16 protein. (222 aa)
FFUJ_06260Polyketide synthase. (2351 aa)
FFUJ_06644Related to MIS1-C1-tetrahydrofolate synthase, mitochondrial. (310 aa)
FFUJ_05961Related to nucleotide diphosphatase. (773 aa)
FFUJ_05998Probable methylcrotonyl-CoA carboxylase beta chain, mitochondrial. (568 aa)
FFUJ_08712Probable dephospho-CoA kinase. (272 aa)
FFUJ_08707annotation not available (416 aa)
FFUJ_07755Uncharacterized protein. (188 aa)
FFUJ_06327Probable phosphopantothenate-cysteine ligase. (365 aa)
FFUJ_08289Related to cytochrome P450 7B1. (569 aa)
FFUJ_06584Related to pyridoxamine 5`-phosphate oxidase. (223 aa)
FFUJ_07597Related to mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (335 aa)
FFUJ_14073Uncharacterized protein. (209 aa)
FFUJ_05491Methyltransf_12 domain-containing protein. (536 aa)
FFUJ_13810Related to NAD kinase. (472 aa)
FFUJ_13807Related to 5`-nucleotidase; Belongs to the 5'-nucleotidase family. (588 aa)
FFUJ_07042Related to FAD1-flavin adenine dinucleotide (FAD) synthetase. (260 aa)
FFUJ_06192Probable pantothenate kinase. (463 aa)
FFUJ_06276Related to null pigmentation protein NpgA. (292 aa)
FFUJ_14374Uncharacterized protein. (523 aa)
FFUJ_06201Probable methylcrotonoyl-CoA carboxylase biotin carboxylase chain. (733 aa)
cnxHMolybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. (164 aa)
FFUJ_06135Related to FMN1-Riboflavin kinase. (210 aa)
FFUJ_14695Related to polyketide synthase. (4090 aa)
FFUJ_05866Related to stilbene synthase 2; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (448 aa)
FFUJ_05840Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (503 aa)
FFUJ_14607Probable pantothenate kinase. (255 aa)
FFUJ_07397Probable Cysteine desulfurase, mitochondrial (TRNA splicing protein SPL1). (502 aa)
FFUJ_13526Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
FFUJ_13326Uncharacterized protein. (513 aa)
FFUJ_08046Uncharacterized protein. (496 aa)
FFUJ_07778Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (260 aa)
FFUJ_02778Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1197 aa)
FFUJ_07589Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (518 aa)
FFUJ_07227Probable C1-tetrahydrofolate synthase. (939 aa)
FFUJ_03424Probable acetyl-CoA carboxylase. (2284 aa)
FFUJ_07153Related to folate transporter/carrier (Mitochondrial); Belongs to the mitochondrial carrier (TC 2.A.29) family. (412 aa)
FFUJ_07069Related to tetrahydrofolylpolyglutamate synthase. (681 aa)
FFUJ_07053VOC domain-containing protein. (137 aa)
FFUJ_13148Related to cytochrome P450 7B1; Belongs to the cytochrome P450 family. (529 aa)
bik1Bikaverin polyketide synthase bik1; Polyketide synthase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre- bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 leads t [...] (2036 aa)
FFUJ_02540Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (713 aa)
FFUJ_02603Probable FAD carrier protein FLX1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
PKS19Polyketide synthase 19; Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fujikurins A-D, secondary metabolites playing a role during rice infection. The polyketide synthase PKS19 acts with the trans- enoyl reductase FFUJ_12240 and the polyketide transferase FFUJ_12241 to produce fujikurins, however, the biosynthesis pathway has not been identified yet. (2492 aa)
FUS1Fusarin C synthetase; Fusarin C synthetase; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C. Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production. The roles of the other FUS members are yet undetermined. The fusarin C synthetase FUS1 is responsible for the condensation of one acetyl-coenzyme A (CoA) unit with six malonyl-CoA units and the amide linkage of the arising heptaketide and homoserine, subsequently releasing the first intermediate, prefusarin, as an alcohol with an open ring structure. The cytochrome P450 monoox [...] (3916 aa)
FFUJ_09730Related to thiamin pyrophosphokinase. (332 aa)
FFUJ_01092Uncharacterized protein. (676 aa)
FUS5Esterase FUS5; Esterase; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C. Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production. The other FUS cluster members are not essential for fusarin C biosynthesis. (233 aa)
FFUJ_10084Related to phosphatase homologous to the C-terminal domain of histone macroH2A1. (603 aa)
FFUJ_09973Related to glucose transporter-3; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (503 aa)
FFUJ_13793Related to polyketide synthase. (270 aa)
FFUJ_06562Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (447 aa)
FFUJ_12707Probable polyketide synthase. (3935 aa)
FFUJ_06128Probable cytochrome b5; Belongs to the cytochrome b5 family. (141 aa)
FFUJ_05814Related to BPL1-biotin holocarboxylase synthetase. (669 aa)
FFUJ_05783Uncharacterized protein. (510 aa)
FFUJ_01842MINDY_DUB domain-containing protein. (836 aa)
FFUJ_01236Related to pyridoxal kinase. (285 aa)
FFUJ_01091Related to hxB protein. (595 aa)
FFUJ_01266ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (341 aa)
FFUJ_01220Related to TPC1-mitochondrial transport protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
FFUJ_01280Probable UTR1 protein, associated with ferric reductase activity. (685 aa)
FFUJ_01079Uncharacterized protein. (258 aa)
FFUJ_00935Probable methylenetetrahydrofolate dehydrogenase (NAD+). (338 aa)
FFUJ_00905Uncharacterized protein. (406 aa)
FFUJ_01926Related to oxidoreductase. (265 aa)
FFUJ_00675Uncharacterized protein. (201 aa)
FFUJ_00559Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (492 aa)
FFUJ_01490Related to glutathione transferase omega 1; Belongs to the GST superfamily. (564 aa)
FFUJ_00108Related to 65 kDa virulence protein. (296 aa)
FFUJ_00359Related to 5^ nucleotidase. (608 aa)
FFUJ_00233Related to glutathione transferase omega 1; Belongs to the GST superfamily. (237 aa)
FFUJ_00118Polyketide synthase. (2538 aa)
FFUJ_00104Related to 65 kDa virulence protein. (516 aa)
uba4Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (448 aa)
FFUJ_04922Probable coenzyme A transporter; Belongs to the mitochondrial carrier (TC 2.A.29) family. (396 aa)
hxBMolybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (828 aa)
FFUJ_00370Related to nicotinate phosphoribosyltransferase. (459 aa)
FFUJ_04721Related to methenyltetrahydrofolate synthetase. (253 aa)
FFUJ_04695Related to tetracycline-efflux transporter. (580 aa)
FFUJ_04415Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (294 aa)
FFUJ_00998Uncharacterized protein. (235 aa)
FFUJ_04441Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (621 aa)
FFUJ_04341Nicotinamide-nucleotide adenylyltransferase; Belongs to the eukaryotic NMN adenylyltransferase family. (276 aa)
FFUJ_04282Related to dihydrofolate reductase. (260 aa)
FFUJ_03730Uncharacterized protein. (496 aa)
FFUJ_04725annotation not available (311 aa)
FFUJ_03734Uncharacterized protein. (326 aa)
FFUJ_04289NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (236 aa)
FUB1Reducing polyketide synthase FUB1; Reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties. L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism. The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively [...] (2410 aa)
FFUJ_00109Uncharacterized protein. (192 aa)
FUB4Hydrolase FUB4; Hydrolase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties. L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O- acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism. The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and l [...] (267 aa)
PKS-NRPS1Trichosetin synthetase PKS-NRPS1; Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of trichosetin, a trans-fused decalin- containing tetramic acid with antimicrobial activity. The PKS module of PKS-NRPS1 together with the enoylreductase (ER) catalyze the formation of the polyketide unit which is then conjugated to L-serine by the condensation domain of the PKS-NRPS1 NRPS module (By similarity). Activity of the Dieckmann cyclase domain (RED) results in release of the intermediate N-desmethylequisetin also called trichosetin (By similarity). Diels-Alder [...] (3914 aa)
FFUJ_04516Related to pyridoxamine-phosphate oxidase. (243 aa)
FFUJ_00560Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (506 aa)
FFUJ_02407CTP_transf_like domain-containing protein. (394 aa)
FFUJ_02689Related to UTR1 (Associated with ferric reductase activity). (605 aa)
FFUJ_02716Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (673 aa)
FSR1Non-reducing polyketide synthase fsr1; Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fusarubins, highly pigmented naphthoquinones responsible for the coloration of the fruiting bodies. The non-reducing polyketide synthase FSR1 is responsible for the condensation of seven acetyl-CoA units to yield a haptaketide. After rings A and B are formed by aldol-type cyclization, the PKS-derived product is released as 6-O-demethylfusarubinaldehyde. Then, two hydroxyl groups at C-5 and C-10 are incorporated by FSR3, and simultaneously hydroxyl groups a [...] (2286 aa)
Your Current Organism:
Fusarium fujikuroi
NCBI taxonomy Id: 1279085
Other names: F. fujikuroi IMI 58289, Fusarium fujikuroi IMI 58289, Fusarium fujikuroi IMI58289, Gibberella fujikuroi IMI 58289
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