(7 nodes) (2013) A functional bikaverin biosynthesis gene cluster in rare strains of Botrytis cinerea is positively controlled by VELVET. network (Fusarium fujikuroi)

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	bik4	Nitrogen metabolite regulation-like protein bik4; Nitrogen metabolite regulation-like protein involved in the regulation of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. (326 aa)
	bik2	FAD-dependent monooxygenase bik2; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 le [...] (489 aa)
	bik3	O-methyltransferase bik3; O-methyltransferase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 leads to the final [...] (453 aa)
	FFUJ_08810	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. (334 aa)
	bik6	Efflux pump bik6; Efflux pump; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin ; Belongs to the major facilitator superfamily. (485 aa)
	bik5	Bikaverin cluster transcription factor bik5; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. (743 aa)
	STC3	(+)-eremophilene synthase; Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpene eremophilene via a 1,10- cyclization, which requires the abstraction of the pyrophosphate from FPP to yield the (E,E)-germacradienyl cation. The only accepted substrate is farnesyl diphosphate (FPP). (357 aa)

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Fusarium fujikuroi

NCBI taxonomy Id: 1279085
Other names: F. fujikuroi IMI 58289, Fusarium fujikuroi IMI 58289, Fusarium fujikuroi IMI58289, Gibberella fujikuroi IMI 58289

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
bik2	bik3	S0E2X6	S0E608	FAD-dependent monooxygenase bik2; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 le [...]	O-methyltransferase bik3; O-methyltransferase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 leads to the final [...]	0.625
bik2	bik4	S0E2X6	S0DZI6	FAD-dependent monooxygenase bik2; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 le [...]	Nitrogen metabolite regulation-like protein bik4; Nitrogen metabolite regulation-like protein involved in the regulation of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	0.627
bik2	bik5	S0E2X6	S0E028	FAD-dependent monooxygenase bik2; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 le [...]	Bikaverin cluster transcription factor bik5; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	0.697
bik2	bik6	S0E2X6	S0DZN4	FAD-dependent monooxygenase bik2; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 le [...]	Efflux pump bik6; Efflux pump; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin ; Belongs to the major facilitator superfamily.	0.703
bik3	bik2	S0E608	S0E2X6	O-methyltransferase bik3; O-methyltransferase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 leads to the final [...]	FAD-dependent monooxygenase bik2; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 le [...]	0.625
bik3	bik4	S0E608	S0DZI6	O-methyltransferase bik3; O-methyltransferase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 leads to the final [...]	Nitrogen metabolite regulation-like protein bik4; Nitrogen metabolite regulation-like protein involved in the regulation of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	0.620
bik3	bik5	S0E608	S0E028	O-methyltransferase bik3; O-methyltransferase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 leads to the final [...]	Bikaverin cluster transcription factor bik5; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	0.614
bik3	bik6	S0E608	S0DZN4	O-methyltransferase bik3; O-methyltransferase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 leads to the final [...]	Efflux pump bik6; Efflux pump; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin ; Belongs to the major facilitator superfamily.	0.619
bik4	bik2	S0DZI6	S0E2X6	Nitrogen metabolite regulation-like protein bik4; Nitrogen metabolite regulation-like protein involved in the regulation of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	FAD-dependent monooxygenase bik2; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 le [...]	0.627
bik4	bik3	S0DZI6	S0E608	Nitrogen metabolite regulation-like protein bik4; Nitrogen metabolite regulation-like protein involved in the regulation of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	O-methyltransferase bik3; O-methyltransferase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 leads to the final [...]	0.620
bik4	bik5	S0DZI6	S0E028	Nitrogen metabolite regulation-like protein bik4; Nitrogen metabolite regulation-like protein involved in the regulation of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	Bikaverin cluster transcription factor bik5; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	0.761
bik4	bik6	S0DZI6	S0DZN4	Nitrogen metabolite regulation-like protein bik4; Nitrogen metabolite regulation-like protein involved in the regulation of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	Efflux pump bik6; Efflux pump; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin ; Belongs to the major facilitator superfamily.	0.618
bik5	bik2	S0E028	S0E2X6	Bikaverin cluster transcription factor bik5; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	FAD-dependent monooxygenase bik2; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 le [...]	0.697
bik5	bik3	S0E028	S0E608	Bikaverin cluster transcription factor bik5; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	O-methyltransferase bik3; O-methyltransferase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 leads to the final [...]	0.614
bik5	bik4	S0E028	S0DZI6	Bikaverin cluster transcription factor bik5; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	Nitrogen metabolite regulation-like protein bik4; Nitrogen metabolite regulation-like protein involved in the regulation of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	0.761
bik5	bik6	S0E028	S0DZN4	Bikaverin cluster transcription factor bik5; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	Efflux pump bik6; Efflux pump; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin ; Belongs to the major facilitator superfamily.	0.619
bik6	bik2	S0DZN4	S0E2X6	Efflux pump bik6; Efflux pump; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin ; Belongs to the major facilitator superfamily.	FAD-dependent monooxygenase bik2; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 le [...]	0.703
bik6	bik3	S0DZN4	S0E608	Efflux pump bik6; Efflux pump; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin ; Belongs to the major facilitator superfamily.	O-methyltransferase bik3; O-methyltransferase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin. The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin. FAD- dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin. A further cycle of oxydation and methylation by bik2 and bik3 leads to the final [...]	0.619
bik6	bik4	S0DZN4	S0DZI6	Efflux pump bik6; Efflux pump; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin ; Belongs to the major facilitator superfamily.	Nitrogen metabolite regulation-like protein bik4; Nitrogen metabolite regulation-like protein involved in the regulation of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	0.618
bik6	bik5	S0DZN4	S0E028	Efflux pump bik6; Efflux pump; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin ; Belongs to the major facilitator superfamily.	Bikaverin cluster transcription factor bik5; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin.	0.619