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FSR1 | Non-reducing polyketide synthase fsr1; Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fusarubins, highly pigmented naphthoquinones responsible for the coloration of the fruiting bodies. The non-reducing polyketide synthase FSR1 is responsible for the condensation of seven acetyl-CoA units to yield a haptaketide. After rings A and B are formed by aldol-type cyclization, the PKS-derived product is released as 6-O-demethylfusarubinaldehyde. Then, two hydroxyl groups at C-5 and C-10 are incorporated by FSR3, and simultaneously hydroxyl groups a [...] (2286 aa) | ||||
GPY2 | ABC transporter GPY2; ABC transporter; part of the gene cluster that mediates the biosynthesis of gibepyrone A, a 2H-pyran-2-one metabolite exhibiting a moderate antimicrobial activity against Gram-positive bacteria and yeasts. GPY2 seems to have a minor impact on the efflux of gibepyrone A out of the cell, but it was shown to repress expression of the key gene GPY1. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. (1432 aa) | ||||
GPY1 | Highly reducing polyketide synthase GPY1; Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of gibepyrone A, a 2H-pyran-2-one metabolite exhibiting a moderate antimicrobial activity against Gram- positive bacteria and yeasts. The highly reducing polyketide synthase GPY1 is sufficient to produce gibepyrone A. GPY1 uses an acetyl-CoA starter unit, three malonyl-CoA extender units, and two SAM-dependent methylations to establish the gibepyrone A carbon backbone, followed by product release upon intramolecular cyclization. The gibepyrone A derivat [...] (2543 aa) |