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STC5 | Inactive (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase; Belongs to the terpene synthase family. (401 aa) | ||||
PKS-NRPS1 | Trichosetin synthetase PKS-NRPS1; Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of trichosetin, a trans-fused decalin- containing tetramic acid with antimicrobial activity. The PKS module of PKS-NRPS1 together with the enoylreductase (ER) catalyze the formation of the polyketide unit which is then conjugated to L-serine by the condensation domain of the PKS-NRPS1 NRPS module (By similarity). Activity of the Dieckmann cyclase domain (RED) results in release of the intermediate N-desmethylequisetin also called trichosetin (By similarity). Diels-Alder [...] (3914 aa) | ||||
BEA1 | Beauvericin nonribosomal cyclodepsipeptide synthetase BEA1; Beauvericin nonribosomal cyclodepsipeptide synthetase; part of the gene cluster that mediates the biosynthesis of beauvericin (BEA), a non-ribosomal cyclic hexadepsipeptide that shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic activity. Ketoisovalerate reductase BEA2 catalyzes the NADPH- specific reduction of ketoisovaleric acid to hydroxyisovalerate, a precursor for beauvericin biosynthesis (By similarity). The nonribosomal cyclodepsipeptide synthetase BEA1 then catalyzes the f [...] (3135 aa) | ||||
LAE1 | Secondary metabolism regulator LAE1; Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the gibberellins gene clusters, but does not affect bikaverin production. Controls the expression of the fusaric acid gene cluster. Acts as a virulence factors during infection, most likely through activation of gibberellins biosynthesis. (316 aa) |