STRINGSTRING
gcvT gcvT amiF amiF AII41876.1 AII41876.1 AII41923.1 AII41923.1 gapA gapA AII41979.1 AII41979.1 AII42059.1 AII42059.1 AII42060.1 AII42060.1 AII42065.1 AII42065.1 AII42102.1 AII42102.1 AII42147.1 AII42147.1 ackA ackA AII42202.1 AII42202.1 AII42281.1 AII42281.1 glyA glyA AII42343.1 AII42343.1 ppc ppc AII42767.1 AII42767.1 tal tal accA accA rbcL rbcL AII42821.1 AII42821.1 folD folD zwf zwf AII42961.1 AII42961.1 accD accD AII42972.1 AII42972.1 AII42973.1 AII42973.1 tpiA tpiA AII43059.1 AII43059.1 prs prs acsA acsA AII43380.1 AII43380.1 AII43406.1 AII43406.1 pgi pgi ilvA ilvA pgl pgl AII43574.1 AII43574.1 glpX glpX AII43578.1 AII43578.1 AII43617.1 AII43617.1 AII43637.1 AII43637.1 AII43873.1 AII43873.1 AII43880.1 AII43880.1 pdhA pdhA AII44025.1 AII44025.1 mqo mqo AII41780.1 AII41780.1 AII44165.1 AII44165.1 rpiA rpiA AII44253.1 AII44253.1 sdhA sdhA AII44255.1 AII44255.1 AII44330.1 AII44330.1 AII44350.1 AII44350.1 AII44462.1 AII44462.1 AII41785.1 AII41785.1 AII44626.1 AII44626.1 AII44634.1 AII44634.1 pgk pgk eno eno fumC fumC gcvP gcvP gcvH gcvH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (368 aa)
amiFFormamidase; Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide; Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family. (348 aa)
AII41876.1Formamidase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (409 aa)
AII41923.1Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aconitase/IPM isomerase family. (860 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase; Required for glycolysis; catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (341 aa)
AII41979.1Carboxylesterase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (158 aa)
AII42059.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (297 aa)
AII42060.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (280 aa)
AII42065.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the pyruvate kinase family. (353 aa)
AII42102.1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (249 aa)
AII42147.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (669 aa)
ackAHypothetical protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (358 aa)
AII42202.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (474 aa)
AII42281.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the LDH/MDH superfamily. (355 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (429 aa)
AII42343.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (200 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (1009 aa)
AII42767.1Histidine phosphatase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the phosphoglycerate mutase family. (450 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 1 subfamily. (390 aa)
accAacetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (329 aa)
rbcLRibulose bisophosphate carboxylase; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. Belongs to the RuBisCO large chain family. Type I subfamily. (471 aa)
AII42821.1Ribulose bisphosphate carboxylase small chain; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (113 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (303 aa)
zwfGlucose 6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (507 aa)
AII42961.1Phosphoribulokinase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (300 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (293 aa)
AII42972.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (355 aa)
AII42973.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (357 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (230 aa)
AII43059.1O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (441 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (331 aa)
acsA3-hydroxypropionyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (657 aa)
AII43380.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (594 aa)
AII43406.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (316 aa)
pgiGlucose-6-phosphate isomerase; Functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the GPI family. (532 aa)
ilvAL-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (509 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (237 aa)
AII43574.16-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (472 aa)
glpXType II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the FBPase class 2 family. (334 aa)
AII43578.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the ribulose-phosphate 3-epimerase family. (227 aa)
AII43617.1Alanine--glyoxylate aminotransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (393 aa)
AII43637.1Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
AII43873.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the bacterial glucokinase family. (360 aa)
AII43880.1Xylose repressor; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (300 aa)
pdhAPyruvate dehydrogenase E1 subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (327 aa)
AII44025.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (480 aa)
mqoMalate:quinone oxidoreductase; Malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (522 aa)
AII41780.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (328 aa)
AII44165.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (446 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (230 aa)
AII44253.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (214 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (638 aa)
AII44255.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (242 aa)
AII44330.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa)
AII44350.1Hypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (388 aa)
AII44462.1acetyl-CoA carboxylase subunit alpha; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
AII41785.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
AII44626.1Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the methylenetetrahydrofolate reductase family. (297 aa)
AII44634.1Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (396 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the phosphoglycerate kinase family. (402 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
fumCHypothetical protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (470 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (958 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
Your Current Organism:
Synechococcus sp. KORDI100
NCBI taxonomy Id: 1280380
Other names: S. sp. KORDI-100, Synechococcus sp. KORDI-100
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