(64 nodes) RHO GTPase cycle, and Ras-like guanine nucleotide exchange factor network (Meira miltonrushii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A316V1E2	Uncharacterized protein. (213 aa)
	A0A316V338	Uncharacterized protein. (532 aa)
	A0A316V3E1	Uncharacterized protein. (283 aa)
	A0A316V4A4	Kinase-like protein. (387 aa)
	A0A316V4M9	24 kDa ras-like protein. (209 aa)
	A0A316V4Z9	NAD(P)-binding protein. (350 aa)
	A0A316V560	Non-specific serine/threonine protein kinase. (624 aa)
	A0A316V5A3	Dbl homology domain-containing protein. (716 aa)
	A0A316V5G4	Zn(2)-C6 fungal-type domain-containing protein. (881 aa)
	A0A316V5L3	Uncharacterized protein. (832 aa)
	A0A316V5R7	Uncharacterized protein. (165 aa)
	A0A316V660	RhoGAP-domain-containing protein. (1523 aa)
	A0A316V6G3	Phosphatases II. (342 aa)
	A0A316V6N1	Actin-related protein; Belongs to the actin family. (378 aa)
	A0A316V6Y0	GTP binding protein Rac1. (193 aa)
	A0A316V6Y3	Kinase-like protein. (165 aa)
	A0A316V734	Putative ras GTPase-activating protein sar1. (800 aa)
	A0A316V741	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1211 aa)
	A0A316V7G8	ELMO domain-containing protein. (798 aa)
	A0A316V7W9	Uncharacterized protein. (247 aa)
	A0A316V814	Uncharacterized protein. (664 aa)
	A0A316V891	Ras GEF. (1340 aa)
	A0A316V8D2	Uncharacterized protein. (643 aa)
	A0A316V8I1	P-loop containing nucleoside triphosphate hydrolase protein. (203 aa)
	A0A316V8M8	DH domain-containing protein. (864 aa)
	A0A316V8R5	DH domain-containing protein. (1132 aa)
	A0A316V9F0	RhoGAP-domain-containing protein. (1171 aa)
	A0A316V9G1	Ras GEF. (1343 aa)
	A0A316V9R4	Ras-domain-containing protein. (217 aa)
	A0A316V9U9	Putative RHO1-GTP-binding protein of the rho subfamily of ras-like protein. (227 aa)
	A0A316V9W2	Uncharacterized protein. (323 aa)
	A0A316V9W9	SH3 domain-containing protein. (67 aa)
	A0A316VAD0	Uncharacterized protein. (1066 aa)
	A0A316VAI2	Rho GDP-dissociation inhibitor. (204 aa)
	A0A316VAS2	RING-type domain-containing protein. (1811 aa)
	A0A316VB12	BZIP domain-containing protein. (660 aa)
	A0A316VB34	Uncharacterized protein. (562 aa)
	A0A316VB53	Rho GTPase activation protein. (599 aa)
	A0A316VBX4	Uncharacterized protein. (205 aa)
	A0A316VCV7	Rho-GAP domain-containing protein. (1022 aa)
	A0A316VDU2	Uncharacterized protein. (469 aa)
	A0A316VDX0	Non-specific serine/threonine protein kinase. (859 aa)
	A0A316VE04	Uncharacterized protein. (1239 aa)
	A0A316VE42	Ras GEF. (511 aa)
	A0A316VEC2	Cell division control protein 42. (191 aa)
	FA14DRAFT_4369	Uncharacterized protein; Belongs to the DOCK family. (2329 aa)
	A0A316VGQ1	Putative GTPase Rho1. (197 aa)
	FA14DRAFT_7322	Uncharacterized protein. (702 aa)
	A0A316VH72	Uncharacterized protein. (452 aa)
	A0A316VI52	Ras-GAP domain-containing protein. (1216 aa)
	A0A316VII2	SH3 domain-containing protein. (211 aa)
	A0A316VIZ3	Uncharacterized protein. (238 aa)
	A0A316VJ70	Uncharacterized protein. (55 aa)
	A0A316VJ91	Small G-protein Ras2. (191 aa)
	A0A316VJJ7	Uncharacterized protein. (191 aa)
	A0A316VJP0	PH domain-containing protein. (2110 aa)
	A0A316VJX6	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	A0A316VK93	Putative RSR1-GTP-binding protein. (192 aa)
	A0A316VL20	Actin-binding FH2. (1426 aa)
	A0A316VL30	Uncharacterized protein. (229 aa)
	A0A316VL69	Uncharacterized protein. (660 aa)
	A0A316VLN3	Uncharacterized protein. (327 aa)
	A0A316VNI3	DH domain-containing protein. (1353 aa)
	A0A316VQB3	Ras-GAP domain-containing protein. (2920 aa)

Your Current Organism:

Meira miltonrushii

NCBI taxonomy Id: 1280837
Other names: ATCC MYA-4883, CBS 12591, M. miltonrushii, MCA 3882, Meira miltonrushii Rush & Aime 2012, Meira sp. JLH-2012, NRRL Y-48820

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A316V1E2	A0A316V338	A0A316V1E2	A0A316V338	Uncharacterized protein.	Uncharacterized protein.	0.571
A0A316V1E2	A0A316V3E1	A0A316V1E2	A0A316V3E1	Uncharacterized protein.	Uncharacterized protein.	0.495
A0A316V1E2	A0A316V4M9	A0A316V1E2	A0A316V4M9	Uncharacterized protein.	24 kDa ras-like protein.	0.415
A0A316V1E2	A0A316V4Z9	A0A316V1E2	A0A316V4Z9	Uncharacterized protein.	NAD(P)-binding protein.	0.509
A0A316V1E2	A0A316V560	A0A316V1E2	A0A316V560	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.568
A0A316V1E2	A0A316V5A3	A0A316V1E2	A0A316V5A3	Uncharacterized protein.	Dbl homology domain-containing protein.	0.623
A0A316V1E2	A0A316V5G4	A0A316V1E2	A0A316V5G4	Uncharacterized protein.	Zn(2)-C6 fungal-type domain-containing protein.	0.561
A0A316V1E2	A0A316V5L3	A0A316V1E2	A0A316V5L3	Uncharacterized protein.	Uncharacterized protein.	0.495
A0A316V1E2	A0A316V660	A0A316V1E2	A0A316V660	Uncharacterized protein.	RhoGAP-domain-containing protein.	0.535
A0A316V1E2	A0A316V6G3	A0A316V1E2	A0A316V6G3	Uncharacterized protein.	Phosphatases II.	0.625
A0A316V1E2	A0A316V6N1	A0A316V1E2	A0A316V6N1	Uncharacterized protein.	Actin-related protein; Belongs to the actin family.	0.446
A0A316V1E2	A0A316V6Y0	A0A316V1E2	A0A316V6Y0	Uncharacterized protein.	GTP binding protein Rac1.	0.784
A0A316V1E2	A0A316V6Y3	A0A316V1E2	A0A316V6Y3	Uncharacterized protein.	Kinase-like protein.	0.568
A0A316V1E2	A0A316V734	A0A316V1E2	A0A316V734	Uncharacterized protein.	Putative ras GTPase-activating protein sar1.	0.560
A0A316V1E2	A0A316V741	A0A316V1E2	A0A316V741	Uncharacterized protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.634
A0A316V1E2	A0A316V7G8	A0A316V1E2	A0A316V7G8	Uncharacterized protein.	ELMO domain-containing protein.	0.405
A0A316V1E2	A0A316V7W9	A0A316V1E2	A0A316V7W9	Uncharacterized protein.	Uncharacterized protein.	0.415
A0A316V1E2	A0A316V814	A0A316V1E2	A0A316V814	Uncharacterized protein.	Uncharacterized protein.	0.571
A0A316V1E2	A0A316V8D2	A0A316V1E2	A0A316V8D2	Uncharacterized protein.	Uncharacterized protein.	0.571
A0A316V1E2	A0A316V8I1	A0A316V1E2	A0A316V8I1	Uncharacterized protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.415

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