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| | gbsA_1 | Glycine betaine aldehyde dehydrogenase gbsA; Belongs to the aldehyde dehydrogenase family. (460 aa) |
| | pdhD_2 | Dihydrolipoamide dehydrogenase component of pyruvate dehydrogenase E3. (459 aa) |
| | acoA_1 | 2-oxoisovalerate dehydrogenase subunit alpha. (315 aa) |
| | bfmBAB_1 | 2-oxoisovalerate dehydrogenase, E1 component, beta subunit. (346 aa) |
| | bfmB_1 | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (432 aa) |
| | pdhD_3 | Dihydrolipoamide dehydrogenase component of pyruvate dehydrogenase E3. (408 aa) |
| | lplA1 | Lipoyltransferase and lipoate-protein ligase. (340 aa) |
| | AKC75066.1 | Hypothetical protein. (257 aa) |
| | AKC75068.1 | Macro domain protein. (265 aa) |
| | AKC75069.1 | Glycine cleavage system H protein. (113 aa) |
| | AKC75070.1 | Luciferase-like monooxygenase. (333 aa) |
| | AKC75071.1 | Flavin oxidoreductase. (397 aa) |
| | manB | Phosphomannomutase. (548 aa) |
| | acsA2 | AMP-dependent synthetase and ligase. (531 aa) |
| | mqo2 | Malate:quinone oxidoreductase 2. (497 aa) |
| | fdaB | Fructose-bisphosphate aldolase. (298 aa) |
| | AKC75242.1 | 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa) |
| | alsS | Acetolactate synthase; Belongs to the TPP enzyme family. (554 aa) |
| | budA1 | Alpha-acetolactate decarboxylase. (234 aa) |
| | AKC75274.1 | D-isomer specific 2-hydroxyacid dehydrogenase family protein. (332 aa) |
| | cidC | Thiamine pyrophosphate enzyme; Belongs to the TPP enzyme family. (579 aa) |
| | ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (318 aa) |
| | AKC75319.1 | D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (330 aa) |
| | gbsA_3 | Glycine betaine aldehyde dehydrogenase gbsA; Belongs to the aldehyde dehydrogenase family. (475 aa) |
| | galU | UTP--glucose-1-phosphate uridylyltransferase subunit GalU. (288 aa) |
| | AKC75380.1 | Oxidoreductase, zinc-binding dehydrogenase family. (347 aa) |
| | gpm | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (228 aa) |
| | AKC75455.1 | Zinc-binding alcohol dehydrogenase. (331 aa) |
| | mqo1 | Malate:quinone oxidoreductase 1. (492 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (230 aa) |
| | AKC75612.1 | Luciferase-like monooxygenase. (333 aa) |
| | fbaA | Tagatose-bisphosphate aldolase. (285 aa) |
| | aldA | Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. (475 aa) |
| | glyA | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | ilvA_1 | Threonine dehydratase biosynthetic, IlvA_1; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (422 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (191 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (456 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (346 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (510 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (322 aa) |
| | AKC75733.1 | Acetolactate synthase 1 regulatory subunit. (80 aa) |
| | ilvB | Acetolactate synthase large subunit. (591 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (562 aa) |
| | AKC75752.1 | Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase. (261 aa) |
| | AKC75772.1 | Class I and II aminotransferase. (428 aa) |
| | AKC75786.1 | 3-carboxy-cis,cis-muconate lactonizing enzyme. (344 aa) |
| | aldH | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (460 aa) |
| | fumC | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (530 aa) |
| | tal | Translaldolase. (237 aa) |
| | acsA | Acetyl-coenzyme A synthetase. (569 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (386 aa) |
| | maeB | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). (409 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (322 aa) |
| | pykA | Pyruvate kinase; Belongs to the pyruvate kinase family. (586 aa) |
| | citZ | Methylcitrate synthase; Belongs to the citrate synthase family. (372 aa) |
| | citC | Isocitrate dehydrogenase. (422 aa) |
| | gapB | Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (341 aa) |
| | gcvT | Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. (363 aa) |
| | gcvPA | Glycine dehydrogenase, subunit 1 (glycine cleavage system P protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (450 aa) |
| | gcvPB | Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (492 aa) |
| | lipM | Lipoate-protein ligase A family protein; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. (276 aa) |
| | lpdA | Dihydrolipoamide dehydrogenase. (474 aa) |
| | acoA_2 | 2-oxoisovalerate dehydrogenase subunit alpha. (333 aa) |
| | bfmBAB_2 | 2-oxoisovalerate dehydrogenase, E1 component, beta subunit. (327 aa) |
| | bfmB_2 | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (442 aa) |
| | gnd | 6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (494 aa) |
| | nudF | ADP-ribose pyrophosphatase, NudF. (180 aa) |
| | kgd | Oxoglutarate dehydrogenase (succinyl-transferring) E1; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (934 aa) |
| | odhB | Dihydrolipoamide succinyltransferase E2 component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (423 aa) |
| | AKC76248.1 | Acylphosphatase. (89 aa) |
| | citB | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa) |
| | tktA | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (662 aa) |
| | gLY1 | Aromatic amino acid beta-eliminating lyase/threonine aldolase. (341 aa) |
| | porB | 2-oxoglutarate ferredoxin oxidoreductase subunitbeta. (288 aa) |
| | porA | Pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein. (599 aa) |
| | sucD | succinate--CoA ligase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (301 aa) |
| | sucC | succinate--CoA ligase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (214 aa) |
| | sdhB | Succinate dehydrogenase iron-sulfur protein. (282 aa) |
| | sdhA | Succinate dehydrogenase flavoprotein subunit. (572 aa) |
| | sdhC | Succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family. (204 aa) |
| | pycA_1 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1114 aa) |
| | pdhD_4 | Dihydrolipoamide dehydrogenase component of pyruvate dehydrogenase E3. (468 aa) |
| | pdhC | Pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase. (433 aa) |
| | pdhB | Pyruvate dehydrogenase E1 component subunit beta. (325 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (370 aa) |
| | AKC76650.1 | Lipoyltransferase and lipoate-protein ligase. (329 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (443 aa) |
| | gudB | NAD-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (414 aa) |
| | lipA | Lipoyl synthase, LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (306 aa) |
| | gcvH | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. (126 aa) |
| | eno | Enolase (2-phosphoglycerate dehydrogenase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa) |
| | pgm | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa) |
| | tpi | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (396 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | AKC77010.1 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (497 aa) |
| | lplA2 | Lipoate-protein ligase A family protein; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. (280 aa) |
| | eutD | Phosphate acetyltransferase. (329 aa) |
| | AKC77066.1 | 6-phospho-3-hexuloisomerase. (182 aa) |
| | hxlA | 3-hexulose-6-phosphate synthase. (210 aa) |
| | ilvE | Branched-chain amino acid aminotransferase. (358 aa) |
| | kbl | Pyridoxal phosphate-dependent acyltransferase. (396 aa) |
| | pdxT | Pyridoxine biosynthesis amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (184 aa) |
| | pdxS | Pyridoxal biosynthesis lyase; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (295 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa) |
| | gltB | Glutamate synthase (NADPH), large subunit. (1506 aa) |
| | AKC77221.1 | Phosphoglycerate mutase family protein; Belongs to the phosphoglycerate mutase family. (192 aa) |
