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pdhD_2 pdhD_2 acoA_1 acoA_1 bfmBAB_1 bfmBAB_1 bfmB_1 bfmB_1 pdhD_3 pdhD_3 AKC75069.1 AKC75069.1 glyA glyA gcvT gcvT gcvPA gcvPA gcvPB gcvPB lpdA lpdA acoA_2 acoA_2 bfmBAB_2 bfmBAB_2 bfmB_2 bfmB_2 kgd kgd odhB odhB gLY1 gLY1 pdhD_4 pdhD_4 pdhC pdhC pdhB pdhB pdhA pdhA gcvH gcvH kbl kbl
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
pdhD_2Dihydrolipoamide dehydrogenase component of pyruvate dehydrogenase E3. (459 aa)
acoA_12-oxoisovalerate dehydrogenase subunit alpha. (315 aa)
bfmBAB_12-oxoisovalerate dehydrogenase, E1 component, beta subunit. (346 aa)
bfmB_1Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (432 aa)
pdhD_3Dihydrolipoamide dehydrogenase component of pyruvate dehydrogenase E3. (408 aa)
AKC75069.1Glycine cleavage system H protein. (113 aa)
glyASerine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
gcvTAminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. (363 aa)
gcvPAGlycine dehydrogenase, subunit 1 (glycine cleavage system P protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (450 aa)
gcvPBGlycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (492 aa)
lpdADihydrolipoamide dehydrogenase. (474 aa)
acoA_22-oxoisovalerate dehydrogenase subunit alpha. (333 aa)
bfmBAB_22-oxoisovalerate dehydrogenase, E1 component, beta subunit. (327 aa)
bfmB_2Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (442 aa)
kgdOxoglutarate dehydrogenase (succinyl-transferring) E1; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (934 aa)
odhBDihydrolipoamide succinyltransferase E2 component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (423 aa)
gLY1Aromatic amino acid beta-eliminating lyase/threonine aldolase. (341 aa)
pdhD_4Dihydrolipoamide dehydrogenase component of pyruvate dehydrogenase E3. (468 aa)
pdhCPyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase. (433 aa)
pdhBPyruvate dehydrogenase E1 component subunit beta. (325 aa)
pdhAPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (370 aa)
gcvHGlycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. (126 aa)
kblPyridoxal phosphate-dependent acyltransferase. (396 aa)
Your Current Organism:
Staphylococcus haemolyticus
NCBI taxonomy Id: 1283
Other names: ATCC 29970, CCM 2737, CCUG 7323, CIP 81.56, DSM 20263, JCM 2416, LMG 13349, LMG:13349, NCTC 11042, NRRL B-14755, S. haemolyticus
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