STRINGSTRING
msrA msrA comEB comEB dfrA_1 dfrA_1 thyA thyA dfrA_2 dfrA_2 msrA-2 msrA-2 msrB msrB AKC76231.1 AKC76231.1 AKC76232.1 AKC76232.1 AKC76233.1 AKC76233.1 msrA-3 msrA-3 AKC76597.1 AKC76597.1 AKC76765.1 AKC76765.1 nrdF nrdF nrdE nrdE nrdI nrdI norA norA tmk tmk
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
msrAMethionine sulfoxide reductase A, MsrA; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (158 aa)
comEBLate competence operon required for DNA binding and uptake comEB. (152 aa)
dfrA_1Trimethoprim-sensitive dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). (165 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (318 aa)
dfrA_2Trimethoprim-sensitive dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (159 aa)
msrA-2Peptide methionine sulfoxide reductase II; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (175 aa)
msrBPeptide methionine sulfoxide reductase MsrB. (142 aa)
AKC76231.1Hypothetical protein; Belongs to the UPF0346 family. (73 aa)
AKC76232.1Serine protease; Belongs to the peptidase S41A family. (490 aa)
AKC76233.1GNAT family acetyltransferase. (167 aa)
msrA-3Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (110 aa)
AKC76597.1Glutaredoxin family protein. (77 aa)
AKC76765.1Thioredoxin. (107 aa)
nrdFRibonucleoside-diphosphate reductase subunit beta. (322 aa)
nrdERibonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (698 aa)
nrdINrdI protein involved in ribonucleotide reductase function; Probably involved in ribonucleotide reductase function. (132 aa)
norAmultidrug/H+ antiporter. (390 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (203 aa)
Your Current Organism:
Staphylococcus haemolyticus
NCBI taxonomy Id: 1283
Other names: ATCC 29970, CCM 2737, CCUG 7323, CIP 81.56, DSM 20263, JCM 2416, LMG 13349, LMG:13349, NCTC 11042, NRRL B-14755, S. haemolyticus
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