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ilvC ilvC leuB leuB fabG_1 fabG_1 AKC75525.1 AKC75525.1 AKC75520.1 AKC75520.1 apbA apbA guaB guaB ldh ldh AKC75319.1 AKC75319.1 capD capD murB murB AKC76738.1 AKC76738.1 fabG_3 fabG_3 dhoM dhoM gpsA gpsA zwf zwf gnd gnd aroE aroE citC citC panE panE AKC75018.1 AKC75018.1 AKC75019.1 AKC75019.1 cap5O cap5O AKC75274.1 AKC75274.1 mvaA mvaA maeB maeB serA serA acuA acuA ribD ribD AKC75849.1 AKC75849.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (322 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (346 aa)
fabG_13-oxoacyl-ACP reductase. (263 aa)
AKC75525.1NAD/NADP octopine/nopaline dehydrogenase family protein. (356 aa)
AKC75520.1D-isomer specific 2-hydroxyacid dehydrogenase family protein. (318 aa)
apbA2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (310 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (318 aa)
AKC75319.1D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (330 aa)
capDNAD dependent epimerase/dehydratase family protein. (318 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (307 aa)
AKC76738.1Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (321 aa)
fabG_33-oxoacyl-ACP reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
dhoMHomoserine dehydrogenase. (431 aa)
gpsANAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (332 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (494 aa)
gnd6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (268 aa)
citCIsocitrate dehydrogenase. (422 aa)
panEKetopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (282 aa)
AKC75018.13-beta hydroxysteroid dehydrogenase/isomerase. (53 aa)
AKC75019.13-beta hydroxysteroid dehydrogenase/isomerase. (272 aa)
cap5OCapsular polysaccharide biosynthesis protein Cap5O. (423 aa)
AKC75274.1D-isomer specific 2-hydroxyacid dehydrogenase family protein. (332 aa)
mvaAhydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family. (425 aa)
maeBMalate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). (409 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (532 aa)
acuAAcetoin dehydrogenase-like protein. (210 aa)
ribDBifunctional pyrimidine reductase / riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (347 aa)
AKC75849.1D-isomer specific 2-hydroxyacid dehydrogenase family protein. (319 aa)
Your Current Organism:
Staphylococcus haemolyticus
NCBI taxonomy Id: 1283
Other names: ATCC 29970, CCM 2737, CCUG 7323, CIP 81.56, DSM 20263, JCM 2416, LMG 13349, LMG:13349, NCTC 11042, NRRL B-14755, S. haemolyticus
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