STRINGSTRING
A966_07619 A966_07619 A966_07644 A966_07644 A966_07649 A966_07649 A966_07994 A966_07994 A966_08219 A966_08219 A966_08224 A966_08224 acpP acpP A966_08304 A966_08304 A966_08369 A966_08369 A966_08539 A966_08539 A966_09014 A966_09014 A966_09044 A966_09044 dxs dxs A966_09429 A966_09429 A966_09541 A966_09541 A966_09721 A966_09721 A966_09761 A966_09761 A966_09766 A966_09766 A966_10302 A966_10302 A966_10582 A966_10582 A966_10797 A966_10797 dxr dxr gpsA gpsA A966_11042 A966_11042 A966_11502 A966_11502 murG murG A966_11741 A966_11741 A966_11771 A966_11771 A966_11791 A966_11791 A966_11796 A966_11796 A966_11806 A966_11806 A966_11811 A966_11811 A966_12001 A966_12001 A966_12236 A966_12236 A966_12501 A966_12501 A966_12723 A966_12723 A966_12728 A966_12728 A966_12733 A966_12733 A966_12873 A966_12873 A966_13038 A966_13038 A966_13345 A966_13345 A966_13505 A966_13505 A966_13645 A966_13645 A966_07614 A966_07614 A966_07459 A966_07459 A966_06525 A966_06525 ispE ispE fabZ fabZ A966_06163 A966_06163 A966_06158 A966_06158 A966_05898 A966_05898 A966_05423 A966_05423 ispG ispG A966_04681 A966_04681 ispH ispH A966_04085 A966_04085 A966_04025 A966_04025 A966_03990 A966_03990 A966_03860 A966_03860 ispF ispF lpxD lpxD A966_03061 A966_03061 fabH-2 fabH-2 A966_02696 A966_02696 A966_02431 A966_02431 fabH fabH plsX plsX A966_02133 A966_02133 plsY plsY A966_01898 A966_01898 A966_01823 A966_01823 A966_01711 A966_01711 A966_01546 A966_01546 kdsB kdsB fabV fabV
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
A966_07619COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (294 aa)
A966_07644Hypothetical protein. (354 aa)
A966_07649Hypothetical protein. (528 aa)
A966_07994COG0859 ADP-heptose:LPS heptosyltransferase. (329 aa)
A966_08219COG2364 Predicted membrane protein. (220 aa)
A966_082243-oxoacyl-ACP (acyl carrier protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (417 aa)
acpPAcyl carrier protein (ACP) Contains: Beta-hemolysin; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa)
A966_08304CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; COG0558 Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (184 aa)
A966_08369COG3884 Acyl-ACP thioesterase. (235 aa)
A966_08539COG2604 Uncharacterized protein conserved in bacteria. (576 aa)
A966_09014Glycosyl transferase; COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases. (232 aa)
A966_09044Monogalactosyldiacylglycerol (MGDG) synthase; COG0707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase. (377 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (617 aa)
A966_09429COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (197 aa)
A966_095413-deoxy-D-manno-2-octulosonate transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (424 aa)
A966_09721Malonyl CoA-ACP transacylase; COG0331 (acyl-carrier-protein) S-malonyltransferase. (304 aa)
A966_09761Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase. (301 aa)
A966_09766Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (240 aa)
A966_10302Molecular chaperone GroES; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (333 aa)
A966_10582L-lactate dehydrogenase; COG0439 Biotin carboxylase. (723 aa)
A966_10797COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains). (511 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (384 aa)
gpsACOG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (333 aa)
A966_11042Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (508 aa)
A966_11502COG1022 Long-chain acyl-CoA synthetases (AMP-forming). (625 aa)
murGN-acetylglucosaminyl transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (357 aa)
A966_11741Lipopolysaccharide heptosyltransferase II; COG0859 ADP-heptose:LPS heptosyltransferase. (347 aa)
A966_11771COG0304 3-oxoacyl-(acyl-carrier-protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (390 aa)
A966_11791COG4261 Predicted acyltransferase. (339 aa)
A966_117963-hydroxyacyl-ACP dehydratase; COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases. (112 aa)
A966_11806COG0236 Acyl carrier protein. (86 aa)
A966_11811Hypothetical protein. (234 aa)
A966_12001All-trans-retinol 13,14-reductase; COG1233 Phytoene dehydrogenase and related proteins. (542 aa)
A966_12236Hypothetical protein; COG0457 FOG: TPR repeat. (467 aa)
A966_12501Hypothetical protein; COG0750 Predicted membrane-associated Zn-dependent proteases 1. (583 aa)
A966_12723COG1250 3-hydroxyacyl-CoA dehydrogenase. (280 aa)
A966_127283-hydroxybutyryl-CoA dehydratase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
A966_12733COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
A966_128732-dehydro-3-deoxyphosphooctonate aldolase; COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; Belongs to the KdsA family. (271 aa)
A966_13038Hypothetical protein. (231 aa)
A966_13345Hypothetical protein. (448 aa)
A966_13505COG1102 Cytidylate kinase. (212 aa)
A966_13645Phosphodiesterase; COG1408 Predicted phosphohydrolases. (297 aa)
A966_07614COG2604 Uncharacterized protein conserved in bacteria. (617 aa)
A966_07459Hypothetical protein; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon). (660 aa)
A966_06525COG0427 Acetyl-CoA hydrolase. (448 aa)
ispEPutative 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (284 aa)
fabZ(3R)-hydroxymyristoyl-ACP dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (154 aa)
A966_06163COG1043 Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase. (264 aa)
A966_06158Putative lipid A disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (376 aa)
A966_05898COG2604 Uncharacterized protein conserved in bacteria. (565 aa)
A966_05423Putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase. (236 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (355 aa)
A966_04681COG2035 Predicted membrane protein. (285 aa)
ispHHydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (581 aa)
A966_04085COG0859 ADP-heptose:LPS heptosyltransferase. (326 aa)
A966_04025COG2035 Predicted membrane protein. (284 aa)
A966_03990UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. Belongs to the LpxC family. (430 aa)
A966_03860Squalene/phytoene synthase-like protein; COG1562 Phytoene/squalene synthetase. (334 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclo diphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (158 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (346 aa)
A966_03061Putative lipid A biosynthesis acyltransferase; COG1560 Lauroyl/myristoyl acyltransferase. (310 aa)
fabH-23-oxoacyl-ACP synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (325 aa)
A966_02696COG0511 Biotin carboxyl carrier protein. (134 aa)
A966_02431Nudix hydrolase; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. (167 aa)
fabH3-oxoacyl-(acyl carrier protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (322 aa)
plsXFatty acid/phospholipid synthesis protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (339 aa)
A966_02133COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III. (284 aa)
plsYPutative GTP-binding protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (215 aa)
A966_01898COG0859 ADP-heptose:LPS heptosyltransferase. (424 aa)
A966_01823Yqi jprotein; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
A966_01711Hypothetical protein; COG0457 FOG: TPR repeat. (399 aa)
A966_01546COG1022 Long-chain acyl-CoA synthetases (AMP-forming). (548 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (256 aa)
fabVtrans-2-enoyl-CoA reductase; Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA); Belongs to the TER reductase family. (392 aa)
Your Current Organism:
Brachyspira hampsonii
NCBI taxonomy Id: 1289135
Other names: B. hampsonii 30446, Brachyspira hampsonii 30446, Brachyspira hampsonii IDAC 16111-01, Brachyspira sp. 30446, Brachyspira sp. IDAC 16111-01
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