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pyrG pyrG guaB guaB TPE_0366 TPE_0366 TPE_0395 TPE_0395 guaA guaA TPE_0660 TPE_0660 TPE_0750 TPE_0750 TPE_0783 TPE_0783 pyrB pyrB TPE_0888 TPE_0888 uraA uraA purD purD pdp pdp TPE_1779 TPE_1779 apt apt purH purH TPE_1884 TPE_1884 purF purF pyrF pyrF purM purM pyrE pyrE pyrH pyrH cdd cdd purN purN TPE_2340 TPE_2340 adk adk purC purC purE purE purQ purQ purL purL deoD deoD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
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pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (550 aa)
guaBInosine 5-monophosphate dehydrogenase. (504 aa)
TPE_0366Dihydroorotase. (351 aa)
TPE_03955'-nucleotidase; Belongs to the 5'-nucleotidase family. (570 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (511 aa)
TPE_0660Phosphatase/nucleotidase; Belongs to the 5'-nucleotidase family. (636 aa)
TPE_0750HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa)
TPE_0783Adenosine deaminase. (299 aa)
pyrBBifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit. (534 aa)
TPE_0888Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding protein; Belongs to the dihydroorotate dehydrogenase family. (599 aa)
uraAUracil transporter. (420 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (436 aa)
pdpPyrimidine-nucleoside phosphorylase. (441 aa)
TPE_1779Adenylosuccinate lyase. (478 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (535 aa)
TPE_1884Phosphoribosyl transferase. (353 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (483 aa)
pyrFOrotidine 5'-phosphate decarboxylase. (294 aa)
purMPhosphoribosylaminoimidazole synthetase. (350 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (235 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (231 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (136 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (193 aa)
TPE_2340Phosphoribulokinase/uridine kinase. (550 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (209 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (320 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit PurE; Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
purQPhosphoribosylformylglycinamidine synthetase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (267 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (945 aa)
deoDPurine nucleoside phosphorylase. (233 aa)
Your Current Organism:
Treponema pedis
NCBI taxonomy Id: 1291379
Other names: T. pedis str. T A4, Treponema pedis str. T A4
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