STRINGSTRING
TPE_0939 TPE_0939 TPE_0017 TPE_0017 rfbB rfbB sdhA sdhA sdhB sdhB eno eno TPE_0269 TPE_0269 TPE_0393 TPE_0393 TPE_0431 TPE_0431 TPE_0432 TPE_0432 TPE_0491 TPE_0491 TPE_0561 TPE_0561 TPE_0564 TPE_0564 TPE_0576 TPE_0576 deoC deoC TPE_0670 TPE_0670 TPE_0760 TPE_0760 nth nth TPE_0826 TPE_0826 fda fda TPE_0879 TPE_0879 TPE_0982 TPE_0982 TPE_0983 TPE_0983 TPE_1041 TPE_1041 TPE_1044 TPE_1044 TPE_1046 TPE_1046 TPE_1047 TPE_1047 pdxS pdxS cbiK cbiK TPE_1176 TPE_1176 TPE_1429 TPE_1429 tpl tpl TPE_1508 TPE_1508 tnaA tnaA TPE_1540 TPE_1540 mltG mltG nnrE nnrE TPE_1779 TPE_1779 TPE_1801 TPE_1801 TPE_1820 TPE_1820 TPE_1890 TPE_1890 ispF ispF megL megL aroC aroC pyrF pyrF citC citC TPE_2043 TPE_2043 TPE_2044 TPE_2044 hutH hutH citE citE citF citF dacA dacA aspA aspA TPE_2413 TPE_2413 dfp dfp purE purE rlpA rlpA TPE_2595 TPE_2595 hutU hutU cobD cobD TPE_2786 TPE_2786 TPE_2787 TPE_2787
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TPE_0939(R)-2-hydroxyglutaryl-CoA dehydratase subunit beta. (390 aa)
TPE_0017Adenylate/guanylate cyclase catalytic. (353 aa)
rfbBdTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (366 aa)
sdhAL-serine dehydratase, iron-sulfur-dependent subunit alpha. (292 aa)
sdhBL-serine dehydratase, iron-sulfur-dependent subunit beta. (220 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa)
TPE_0269L-fuculose phosphate aldolase. (366 aa)
TPE_0393HEAT repeat-containing PBS lyase. (488 aa)
TPE_0431(R)-2-hydroxyglutaryl-CoA dehydratase subunit beta. (418 aa)
TPE_0432Hypothetical protein. (266 aa)
TPE_04913-dehydroquinate synthase. (353 aa)
TPE_0561Adenylate/guanylate cyclase catalytic. (796 aa)
TPE_0564Hypothetical protein. (194 aa)
TPE_0576Hypothetical protein. (254 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (216 aa)
TPE_0670Hypothetical protein. (770 aa)
TPE_0760Threonine synthase. (437 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (214 aa)
TPE_0826Hypothetical protein; Belongs to the LarC family. (454 aa)
fdaFructose-1,6-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (305 aa)
TPE_0879HEAT repeat-containing protein. (110 aa)
TPE_0982Adenylate/guanylate cyclase catalytic. (624 aa)
TPE_0983Adenylate/guanylate cyclase catalytic. (689 aa)
TPE_1041Oxaloacetate decarboxylase. (457 aa)
TPE_1044Na+ transporting oxaloacetate decarboxylasesubunit beta. (372 aa)
TPE_1046Citrate lyase beta chain; Belongs to the HpcH/HpaI aldolase family. (294 aa)
TPE_1047Citrate lyase alpha chain. (514 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (282 aa)
cbiKCobalt chelatase. (271 aa)
TPE_1176Methylaspartate ammonia-lyase. (412 aa)
TPE_1429Hypothetical protein; Belongs to the UPF0597 family. (431 aa)
tplTyrosine phenol-lyase. (459 aa)
TPE_1508Pyridoxal-dependent family decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (389 aa)
tnaATryptophanase; Belongs to the beta-eliminating lyase family. (463 aa)
TPE_1540VanZ family protein. (133 aa)
mltGHypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (342 aa)
nnrECarbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] (493 aa)
TPE_1779Adenylosuccinate lyase. (478 aa)
TPE_1801Threonine synthase. (501 aa)
TPE_1820(3R)-hydroxymyristoyl-ACP dehydratase. (143 aa)
TPE_1890Malate dehydrogenase. (498 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa)
megLMethionine gamma-lyase. (403 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (351 aa)
pyrFOrotidine 5'-phosphate decarboxylase. (294 aa)
citCCitrate lyase ligase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (344 aa)
TPE_2043Fumarate hydratase. (186 aa)
TPE_2044Fumarate hydratase. (281 aa)
hutHHistidine ammonia-lyase. (507 aa)
citECitrate lyase subunit beta; Belongs to the HpcH/HpaI aldolase family. (283 aa)
citFCitrate lyase subunit alpha. (499 aa)
dacAHypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (275 aa)
aspAAspartate ammonia-lyase. (454 aa)
TPE_2413Lactoylglutathione lyase. (129 aa)
dfpFused 4'-phosphopantothenoylcysteinedecarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (396 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit PurE; Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
rlpARlpA family lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (329 aa)
TPE_2595Adenylate cyclase. (638 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (675 aa)
cobDCobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (323 aa)
TPE_2786Diguanylate cyclase. (1767 aa)
TPE_2787Diguanylate cyclase. (1775 aa)
Your Current Organism:
Treponema pedis
NCBI taxonomy Id: 1291379
Other names: T. pedis str. T A4, Treponema pedis str. T A4
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