STRINGSTRING
TPE_0236 TPE_0236 dnaB dnaB sH sH TPE_2647 TPE_2647 lon lon cadA cadA uvrB uvrB pcrA pcrA TPE_2130 TPE_2130 hslU hslU fliI fliI TPE_1981 TPE_1981 TPE_1965 TPE_1965 ruvB ruvB uvrA uvrA mutL mutL smc smc mutS2 mutS2 TPE_1250 TPE_1250 TPE_1249 TPE_1249 TPE_1126 TPE_1126 clpX clpX clpB clpB ychF ychF TPE_1033 TPE_1033 TPE_1013 TPE_1013 TPE_0994 TPE_0994 TPE_0874 TPE_0874 recG recG TPE_0620 TPE_0620 TPE_0589 TPE_0589 htpG htpG ruvA ruvA TPE_0193 TPE_0193 clpA clpA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TPE_0236Hypothetical protein. (127 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (452 aa)
sHCell division protein sH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (675 aa)
TPE_2647ATPase. (331 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (789 aa)
cadACadmium-translocating P-type ATPase. (750 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (662 aa)
pcrAATP-dependent DNA helicase PcrA. (658 aa)
TPE_2130AAA ATPase. (587 aa)
hslUATP-dependent protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (487 aa)
fliIFlagellum-specific ATP synthase FliI. (474 aa)
TPE_1981ATP-dependent DNA helicase UvrD. (788 aa)
TPE_1965AAA ATPase; Belongs to the ClpA/ClpB family. (840 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (345 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (957 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (633 aa)
smcChromosome partition protein SmC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (981 aa)
mutS2MutS family DNA mismatch repair protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (830 aa)
TPE_1250Arsenical pump-driving ATPase. (387 aa)
TPE_1249Arsenical pump-driving ATPase. (399 aa)
TPE_1126Heavy metal translocating P-type ATPase. (699 aa)
clpXATP-dependent protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (411 aa)
clpBATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (859 aa)
ychFGTP-dependent nucleic acid-binding protein EngD; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (368 aa)
TPE_1033ParA family ATPase. (251 aa)
TPE_1013Hypothetical protein. (57 aa)
TPE_0994ATPase AAA; Belongs to the AAA ATPase family. (341 aa)
TPE_0874ATPase AAA. (429 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (683 aa)
TPE_0620Hypothetical protein. (936 aa)
TPE_0589Methanol dehydrogenase regulatory protein MoxR. (332 aa)
htpGHeat shock protein 90; Molecular chaperone. Has ATPase activity. (632 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)
TPE_0193SMC domain-containing protein. (218 aa)
clpAATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. (843 aa)
Your Current Organism:
Treponema pedis
NCBI taxonomy Id: 1291379
Other names: T. pedis str. T A4, Treponema pedis str. T A4
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