STRINGSTRING
arcA arcA TPE_0072 TPE_0072 clpS clpS xseA xseA eno eno TPE_0325 TPE_0325 gpsA gpsA TPE_0331 TPE_0331 TPE_0395 TPE_0395 TPE_0422 TPE_0422 hgdC hgdC TPE_0492 TPE_0492 TPE_0529 TPE_0529 rnhA rnhA kamA kamA nagB nagB deoC deoC TPE_0660 TPE_0660 pgi pgi TPE_0711 TPE_0711 hutI hutI TPE_0750 TPE_0750 TPE_0827 TPE_0827 TPE_0833 TPE_0833 mtnN mtnN fda fda yoeB yoeB TPE_0846 TPE_0846 TPE_0874 TPE_0874 TPE_0878 TPE_0878 TPE_0955 TPE_0955 pnp pnp mamA mamA dut dut TPE_1116 TPE_1116 rpe rpe rny rny TPE_1176 TPE_1176 glmE glmE TPE_1327 TPE_1327 pgk pgk TPE_1419 TPE_1419 TPE_1429 TPE_1429 TPE_1479 TPE_1479 TPE_1540 TPE_1540 TPE_1657 TPE_1657 TPE_1677 TPE_1677 TPE_1743 TPE_1743 gap gap gcvT gcvT gcvH gcvH gcvP1 gcvP1 gcvP2 gcvP2 xseB xseB TPE_1852 TPE_1852 pepT pepT rnhB rnhB TPE_2036 TPE_2036 TPE_2051 TPE_2051 hutH hutH hslV hslV cdd cdd csrA csrA glpK glpK pyk pyk TPE_2302 TPE_2302 TPE_2319 TPE_2319 argF argF TPE_2418 TPE_2418 dfp dfp TPE_2528 TPE_2528 lon lon sH sH hutU hutU TPE_2714 TPE_2714 pfp pfp tpiA tpiA gpmA gpmA pfk pfk deoD deoD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
arcAArginine deiminase. (409 aa)
TPE_0072Hexokinase. (436 aa)
clpSATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (101 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (395 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa)
TPE_0325Hypothetical protein. (354 aa)
gpsANAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (357 aa)
TPE_0331RelE/StbE family addiction module toxin. (91 aa)
TPE_03955'-nucleotidase; Belongs to the 5'-nucleotidase family. (570 aa)
TPE_0422Endoribonuclease L-PSP. (125 aa)
hgdC(R)-hydroxyglutaryl-CoA dehydratase activator. (250 aa)
TPE_0492MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (242 aa)
TPE_0529Metallo-beta-lactamase. (213 aa)
rnhARibonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (150 aa)
kamALysine 2,3-aminomutase. (360 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. (263 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (216 aa)
TPE_0660Phosphatase/nucleotidase; Belongs to the 5'-nucleotidase family. (636 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (525 aa)
TPE_0711Hypothetical protein. (181 aa)
hutIImidazolonepropionase. (405 aa)
TPE_0750HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa)
TPE_0827Formiminotransferase. (298 aa)
TPE_0833MTA/SAH nucleosidase. (227 aa)
mtnNGroES-like protein. (351 aa)
fdaFructose-1,6-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (305 aa)
yoeBToxin of the YoeB-YefM toxin-antitoxin system. (87 aa)
TPE_0846Txe/YoeB family addiction module toxin. (87 aa)
TPE_0874ATPase AAA. (429 aa)
TPE_0878Hypothetical protein. (62 aa)
TPE_0955Hypothetical protein. (116 aa)
pnpPolynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (697 aa)
mamAMethylaspartate mutase subunit S; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (141 aa)
dutDeoxyuridine 5'triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (146 aa)
TPE_1116FAD-binding protein. (281 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (209 aa)
rny2,3 cyclic-nucleotide 2-phosphodiesterase; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (509 aa)
TPE_1176Methylaspartate ammonia-lyase. (412 aa)
glmEMethylaspartate mutase subunit E; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (485 aa)
TPE_1327Hypothetical protein. (249 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (418 aa)
TPE_1419N-acetylmuramoyl-L-alanine amidase. (360 aa)
TPE_1429Hypothetical protein; Belongs to the UPF0597 family. (431 aa)
TPE_1479Metal dependent phosphohydrolase. (223 aa)
TPE_1540VanZ family protein. (133 aa)
TPE_1657Hypothetical protein. (288 aa)
TPE_1677Nucleoside triphosphate pyrophosphohydrolase MazG. (285 aa)
TPE_1743Putative glycoside hydrolase family protein; Belongs to the glycosyl hydrolase 5 (cellulase A) family. (579 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (369 aa)
gcvTGlycine cleavage system T protein. (357 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (122 aa)
gcvP1Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (431 aa)
gcvP2Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (483 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (78 aa)
TPE_1852Hypothetical protein. (86 aa)
pepTPeptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. (410 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (199 aa)
TPE_2036Hypothetical protein. (449 aa)
TPE_20513-hydroxyacid dehydrogenase. (292 aa)
hutHHistidine ammonia-lyase. (507 aa)
hslVATP-dependent protease peptidase subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (178 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (136 aa)
csrACarbon storage regulator; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW. (76 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (519 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (471 aa)
TPE_2302Hypothetical protein. (199 aa)
TPE_2319Patatin. (303 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (338 aa)
TPE_2418Hypothetical protein. (127 aa)
dfpFused 4'-phosphopantothenoylcysteinedecarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (396 aa)
TPE_2528Metal dependent phosphohydrolase. (416 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (789 aa)
sHCell division protein sH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (675 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (675 aa)
TPE_2714Peptidase S16. (800 aa)
pfpDiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (563 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (247 aa)
pfkDiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (438 aa)
deoDPurine nucleoside phosphorylase. (233 aa)
Your Current Organism:
Treponema pedis
NCBI taxonomy Id: 1291379
Other names: T. pedis str. T A4, Treponema pedis str. T A4
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