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guaB guaB TPE_0395 TPE_0395 guaA guaA nrdA nrdA nrdF nrdF prs prs TPE_0660 TPE_0660 TPE_0706 TPE_0706 TPE_0750 TPE_0750 TPE_0783 TPE_0783 TPE_1197 TPE_1197 TPE_1422 TPE_1422 purD purD arcC arcC TPE_1779 TPE_1779 apt apt purH purH purF purF purM purM nrdD nrdD TPE_2214 TPE_2214 pyk pyk purN purN adk adk TPE_2364 TPE_2364 purC purC purE purE purQ purQ TPE_2574 TPE_2574 TPE_2595 TPE_2595 purL purL deoD deoD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
guaBInosine 5-monophosphate dehydrogenase. (504 aa)
TPE_03955'-nucleotidase; Belongs to the 5'-nucleotidase family. (570 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (511 aa)
nrdARibonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (873 aa)
nrdFRibonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (351 aa)
prsPhosphoribosylpyrophosphate synthetase; Belongs to the ribose-phosphate pyrophosphokinase family. (417 aa)
TPE_0660Phosphatase/nucleotidase; Belongs to the 5'-nucleotidase family. (636 aa)
TPE_0706GTP pyrophosphokinase. (247 aa)
TPE_0750HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa)
TPE_0783Adenosine deaminase. (299 aa)
TPE_1197Adenylate/guanylate cyclase catalytic. (934 aa)
TPE_1422RelA/SpoT. (447 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (436 aa)
arcCCarbamate kinase; Belongs to the carbamate kinase family. (310 aa)
TPE_1779Adenylosuccinate lyase. (478 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (535 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (483 aa)
purMPhosphoribosylaminoimidazole synthetase. (350 aa)
nrdDAnaerobic ribonucleoside triphosphate reductase. (706 aa)
TPE_2214Phosphohexose mutase. (587 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (471 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (193 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (209 aa)
TPE_2364MutT/nudix; Belongs to the Nudix hydrolase family. (192 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (320 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit PurE; Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
purQPhosphoribosylformylglycinamidine synthetase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (267 aa)
TPE_2574Phosphohexose mutase. (631 aa)
TPE_2595Adenylate cyclase. (638 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (945 aa)
deoDPurine nucleoside phosphorylase. (233 aa)
Your Current Organism:
Treponema pedis
NCBI taxonomy Id: 1291379
Other names: T. pedis str. T A4, Treponema pedis str. T A4
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