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AGI22025.1 AGI22025.1 gcvT gcvT gcvH gcvH gcvP gcvP glcB glcB AGI22360.1 AGI22360.1 AGI22398.1 AGI22398.1 AGI22464.1 AGI22464.1 glyA glyA AGI23341.1 AGI23341.1 glcF glcF AGI23554.1 AGI23554.1 AGI23555.1 AGI23555.1 acsA acsA AGI23620.1 AGI23620.1 AGI23772.1 AGI23772.1 AGI23773.1 AGI23773.1 AGI23774.1 AGI23774.1 AGI23775.1 AGI23775.1 AGI23960.1 AGI23960.1 AGI24017.1 AGI24017.1 AGI24072.1 AGI24072.1 AGI24097.1 AGI24097.1 AGI24198.1 AGI24198.1 AGI24200.1 AGI24200.1 AGI24266.1 AGI24266.1 AGI24474.1 AGI24474.1 AGI24488.1 AGI24488.1 AGI24509.1 AGI24509.1 AGI24618.1 AGI24618.1 AGI24661.1 AGI24661.1 gltA gltA AGI24881.1 AGI24881.1 acnA acnA AGI25084.1 AGI25084.1 AGI25223.1 AGI25223.1 AGI25245.1 AGI25245.1 AGI25513.1 AGI25513.1 AGI25526.1 AGI25526.1 AGI25774.1 AGI25774.1 AGI25817.1 AGI25817.1 AGI25888.1 AGI25888.1 AGI25892.1 AGI25892.1 purU purU acsA-2 acsA-2 AGI26149.1 AGI26149.1 AGI26174.1 AGI26174.1 AGI26175.1 AGI26175.1 AGI26176.1 AGI26176.1 AGI26177.1 AGI26177.1 AGI26440.1 AGI26440.1 AGI26460.1 AGI26460.1 AGI26615.1 AGI26615.1 AGI26617.1 AGI26617.1 glyA-2 glyA-2 purU-2 purU-2 AGI26838.1 AGI26838.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AGI22025.1Had family hydrolase; COG0546 Predicted phosphatases. (214 aa)
gcvTGlycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (360 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (958 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)
AGI22360.1COG0174 Glutamine synthetase. (449 aa)
AGI22398.1Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (272 aa)
AGI22464.1COG0753 Catalase; Belongs to the catalase family. (482 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
AGI23341.1COG1929 Glycerate kinase; Belongs to the glycerate kinase type-1 family. (379 aa)
glcFGlycolate oxidase iron-sulfur subunit; COG0247 Fe-S oxidoreductase. (424 aa)
AGI23554.1FAD linked oxidase domain-containing protein; COG0277 FAD/FMN-containing dehydrogenases. (346 aa)
AGI23555.1Glycolate oxidase subunit GlcD; COG0277 FAD/FMN-containing dehydrogenases. (499 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
AGI23620.1Hypothetical protein; COG0174 Glutamine synthetase. (446 aa)
AGI23772.1Putative hydroxypyruvate reductase; COG2379 Putative glycerate kinase. (423 aa)
AGI23773.1Oxidoreductase; COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (296 aa)
AGI23774.1COG3622 Hydroxypyruvate isomerase; Belongs to the hyi family. (260 aa)
AGI23775.1COG3960 Glyoxylate carboligase; Belongs to the TPP enzyme family. (591 aa)
AGI23960.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
AGI24017.1Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; COG1049 Aconitase B; Belongs to the aconitase/IPM isomerase family. (869 aa)
AGI24072.1COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (466 aa)
AGI24097.1COG0372 Citrate synthase. (257 aa)
AGI24198.1Putative AMP-binding protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (554 aa)
AGI24200.1acyl-CoA thiolase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
AGI24266.1COG0174 Glutamine synthetase. (452 aa)
AGI24474.1COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (468 aa)
AGI24488.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
AGI24509.1Catalase; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (345 aa)
AGI24618.1COG2224 Isocitrate lyase. (531 aa)
AGI24661.1COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (478 aa)
gltACOG0372 Citrate synthase; Belongs to the citrate synthase family. (427 aa)
AGI24881.1COG0174 Glutamine synthetase. (454 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (910 aa)
AGI25084.1Putative hydrolase; COG0546 Predicted phosphatases. (231 aa)
AGI25223.1Putative aldolase; COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase. (216 aa)
AGI25245.1COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase. (215 aa)
AGI25513.1(R)-specific enoyl-CoA hydratase; COG2030 Acyl dehydratase. (156 aa)
AGI25526.1COG3622 Hydroxypyruvate isomerase; Belongs to the hyi family. (263 aa)
AGI25774.1Putative 2-hydroxyacid dehydrogenase; COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
AGI25817.1Beta-ketothiolase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
AGI25888.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
AGI25892.1COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (321 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa)
acsA-2acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (645 aa)
AGI26149.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
AGI26174.1COG2864 Cytochrome b subunit of formate dehydrogenase. (208 aa)
AGI26175.1Nitrate-inducible formate dehydrogenase subunit beta; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (310 aa)
AGI26176.1Formate dehydrogenase-O, major subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (812 aa)
AGI26177.1Twin-arginine translocation pathway signal; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing. (196 aa)
AGI26440.1COG3741 N-formylglutamate amidohydrolase. (267 aa)
AGI26460.1COG0174 Glutamine synthetase. (469 aa)
AGI26615.1COG0174 Glutamine synthetase. (452 aa)
AGI26617.1COG0174 Glutamine synthetase. (459 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa)
AGI26838.1Glutamate--putrescine ligase; COG0174 Glutamine synthetase. (455 aa)
Your Current Organism:
Pseudomonas sp. ATCC 13867
NCBI taxonomy Id: 1294143
Other names: P. sp. ATCC 13867, Pseudomonas denitrificans ATCC 13867
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