(32 nodes) Pyrimidine metabolism network (Sulfolobus sp. JCM16833)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dcd	Unannotated protein; Catalyzes the deamination of dCTP to dUTP. (172 aa)
	pyrG	Unannotated protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (532 aa)
	ndk	Unannotated protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (140 aa)
	upp	Unannotated protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa)
	cmk	Unannotated protein. (182 aa)
	IC006_1680	Unannotated protein. (119 aa)
	thyX	Unannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (253 aa)
	IC006_1456	Unannotated protein. (409 aa)
	IC006_1141	Unannotated protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (826 aa)
	pyrH	Unannotated protein; Catalyzes the reversible phosphorylation of UMP to UDP. (158 aa)
	tmk	Unannotated protein. (187 aa)
	IC006_1331	Unannotated protein. (283 aa)
	IC006_1332	Unannotated protein. (385 aa)
	pyrI	Unannotated protein; Involved in allosteric regulation of aspartate carbamoyltransferase. (155 aa)
	pyrB	Unannotated protein. (306 aa)
	pyrE	Unannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (194 aa)
	IC006_1337	Unannotated protein. (220 aa)
	carA	Unannotated protein; Belongs to the CarA family. (371 aa)
	carB	Unannotated protein; Belongs to the CarB family. (423 aa)
	IC006_0769	Unannotated protein. (211 aa)
	IC006_2504	Unannotated protein. (400 aa)
	IC006_2501	Unannotated protein. (398 aa)
	IC006_2499	Unannotated protein. (432 aa)
	IC006_2497	Unannotated protein. (264 aa)
	IC006_2473	Unannotated protein. (409 aa)
	IC006_2437	Unannotated protein. (406 aa)
	tmk-2	Unannotated protein. (162 aa)
	IC006_1036	Unannotated protein. (212 aa)
	IC006_2333	Unannotated protein. (293 aa)
	IC006_2428	Unannotated protein. (278 aa)
	IC006_2427	Unannotated protein. (348 aa)
	IC006_2426	Unannotated protein. (288 aa)

Your Current Organism:

Sulfolobus sp. JCM16833

NCBI taxonomy Id: 1294262
Other names: S. sp. JCM 16833, Sulfolobus sp. DSM 104736, Sulfolobus sp. JCM 16833

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IC006_0769	IC006_1036	GCA_001316085_01668	GCA_001316085_02466	Unannotated protein.	Unannotated protein.	0.920
IC006_0769	IC006_1141	GCA_001316085_01668	GCA_001316085_01092	Unannotated protein.	Unannotated protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	0.999
IC006_0769	cmk	GCA_001316085_01668	GCA_001316085_00334	Unannotated protein.	Unannotated protein.	0.900
IC006_0769	ndk	GCA_001316085_01668	GCA_001316085_00185	Unannotated protein.	Unannotated protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	0.932
IC006_0769	pyrG	GCA_001316085_01668	GCA_001316085_00152	Unannotated protein.	Unannotated protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.437
IC006_0769	tmk	GCA_001316085_01668	GCA_001316085_01227	Unannotated protein.	Unannotated protein.	0.920
IC006_0769	tmk-2	GCA_001316085_01668	GCA_001316085_02464	Unannotated protein.	Unannotated protein.	0.920
IC006_1036	IC006_0769	GCA_001316085_02466	GCA_001316085_01668	Unannotated protein.	Unannotated protein.	0.920
IC006_1036	IC006_1141	GCA_001316085_02466	GCA_001316085_01092	Unannotated protein.	Unannotated protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	0.944
IC006_1036	ndk	GCA_001316085_02466	GCA_001316085_00185	Unannotated protein.	Unannotated protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	0.920
IC006_1036	thyX	GCA_001316085_02466	GCA_001316085_00460	Unannotated protein.	Unannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.924
IC006_1036	tmk	GCA_001316085_02466	GCA_001316085_01227	Unannotated protein.	Unannotated protein.	0.943
IC006_1036	tmk-2	GCA_001316085_02466	GCA_001316085_02464	Unannotated protein.	Unannotated protein.	0.982
IC006_1141	IC006_0769	GCA_001316085_01092	GCA_001316085_01668	Unannotated protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Unannotated protein.	0.999
IC006_1141	IC006_1036	GCA_001316085_01092	GCA_001316085_02466	Unannotated protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Unannotated protein.	0.944
IC006_1141	cmk	GCA_001316085_01092	GCA_001316085_00334	Unannotated protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Unannotated protein.	0.904
IC006_1141	dcd	GCA_001316085_01092	GCA_001316085_00139	Unannotated protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Unannotated protein; Catalyzes the deamination of dCTP to dUTP.	0.537
IC006_1141	ndk	GCA_001316085_01092	GCA_001316085_00185	Unannotated protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Unannotated protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	0.934
IC006_1141	pyrE	GCA_001316085_01092	GCA_001316085_01309	Unannotated protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Unannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).	0.485
IC006_1141	pyrG	GCA_001316085_01092	GCA_001316085_00152	Unannotated protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Unannotated protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.429