STRINGSTRING
gatD gatD AGN26838.1 AGN26838.1 folD folD purQ purQ ureC ureC AGY50227.1 AGY50227.1 AGN25421.1 AGN25421.1 AGN25450.1 AGN25450.1 AGN25461.1 AGN25461.1 pyrC pyrC mptA mptA AGN25932.1 AGN25932.1 AGN25957.1 AGN25957.1 pdxT pdxT AGN26031.1 AGN26031.1 AGN26102.1 AGN26102.1 AGN26197.1 AGN26197.1 dcd dcd AGY50204.1 AGY50204.1 hisI hisI pyrG pyrG ureA ureA nadE nadE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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gatDglutamyl-tRNA(Gln) amidotransferase subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (431 aa)
AGN26838.1COG1546 Uncharacterized protein (competence- and mitomycin-induced). (155 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (278 aa)
ureCUrease subunit alpha; COG0804 Urea amidohydrolase (urease) alpha subunit; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (573 aa)
AGY50227.1Urease subunit gamma; COG0832 Urea amidohydrolase (urease) beta subunit. (140 aa)
AGN25421.1dCMP deaminase; COG2131 Deoxycytidylate deaminase. (151 aa)
AGN25450.1COG0726 Predicted xylanase/chitin deacetylase. (268 aa)
AGN25461.1COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). (518 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (421 aa)
mptAGTP cyclohydrolase; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (293 aa)
AGN25932.1COG1402 Uncharacterized protein, putative amidase. (236 aa)
AGN25957.1Metal-dependent hydrolase; COG0402 Cytosine deaminase and related metal-dependent hydrolases. (429 aa)
pdxTGlutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (196 aa)
AGN26031.1Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; COG0388 Predicted amidohydrolase. (278 aa)
AGN26102.1COG3070 Regulator of competence-specific genes. (80 aa)
AGN26197.1TfoX domain-containing protein; COG3070 Regulator of competence-specific genes. (88 aa)
dcdCOG0717 Deoxycytidine deaminase. (164 aa)
AGY50204.1Imidazole glycerol phosphate synthase amidotransferase subunit; COG0118 Glutamine amidotransferase. (185 aa)
hisIBifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; COG0139 Phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (203 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
ureAUrease subunit gamma; COG0831 Urea amidohydrolase (urease) gamma subunit. (107 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (263 aa)
Your Current Organism:
Methanomassiliicoccus intestinalis
NCBI taxonomy Id: 1295009
Other names: C. Methanomassiliicoccus intestinalis Issoire-Mx1, Candidatus Methanomassiliicoccus intestinalis Issoire-Mx1
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