STRINGSTRING
AGN25596.1 AGN25596.1 AGN25568.1 AGN25568.1 AGN25546.1 AGN25546.1 AGN25502.1 AGN25502.1 msrA msrA AGN25442.1 AGN25442.1 AGN27166.1 AGN27166.1 AGN27157.1 AGN27157.1 AGN27080.1 AGN27080.1 AGN27043.1 AGN27043.1 AGN27025.1 AGN27025.1 AGN26956.1 AGN26956.1 AGN26890.1 AGN26890.1 AGN26885.1 AGN26885.1 hel308 hel308 fen fen AGN26601.1 AGN26601.1 AGN26516.1 AGN26516.1 AGN26430.1 AGN26430.1 AGN26428.1 AGN26428.1 AGN26427.1 AGN26427.1 AGY50184.1 AGY50184.1 AGN26300.1 AGN26300.1 AGN26274.1 AGN26274.1 AGN26246.1 AGN26246.1 nfo nfo nth nth ogt ogt AGN26001.1 AGN26001.1 AGN26000.1 AGN26000.1 radA radA radB radB lig lig AGN25908.1 AGN25908.1 AGN25644.1 AGN25644.1 AGN25634.1 AGN25634.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGN25596.1Uracil-DNA glycosylase, family 4; COG1573 Uracil-DNA glycosylase. (175 aa)
AGN25568.1COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins. (447 aa)
AGN25546.1Hypothetical protein; COG3467 Predicted flavin-nucleotide-binding protein. (159 aa)
AGN25502.1COG1201 Lhr-like helicases. (646 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (317 aa)
AGN25442.1Putative ATP-dependent helicase; COG1201 Lhr-like helicases. (910 aa)
AGN27166.1DNA-(apurinic or apyrimidinic site) lyase; COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase. (263 aa)
AGN27157.1COG0178 Excinuclease ATPase subunit. (850 aa)
AGN27080.1Hypothetical protein; COG1082 Sugar phosphate isomerases/epimerases. (250 aa)
AGN27043.1COG0492 Thioredoxin reductase. (294 aa)
AGN27025.1COG1966 Carbon starvation protein, predicted membrane protein. (571 aa)
AGN26956.1Xylose isomerase domain protein TIM barrel; COG0648 Endonuclease IV. (396 aa)
AGN26890.1SMC domain-containing protein; COG1196 Chromosome segregation ATPases. (427 aa)
AGN26885.1Putative phosphoesterase, SbcD/Mre11-related protein; COG1407 Predicted ICC-like phosphoesterases. (241 aa)
hel308Ski2-like helicase; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (731 aa)
fenFlap structure-specific endonuclease FEN-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision [...] (350 aa)
AGN26601.1Hypothetical protein; COG1533 DNA repair photolyase. (290 aa)
AGN26516.1Hypothetical protein; COG4172 ABC-type uncharacterized transport system, duplicated ATPase component. (747 aa)
AGN26430.1PHP domain-containing protein; COG1796 DNA polymerase IV (family X). (542 aa)
AGN26428.1Hypothetical protein; Involved in DNA damage repair. (427 aa)
AGN26427.1COG1533 DNA repair photolyase. (259 aa)
AGY50184.1COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins. (137 aa)
AGN26300.1Radical SAM-superfamily protein; COG1533 DNA repair photolyase. (292 aa)
AGN26274.1Hypothetical protein. (901 aa)
AGN26246.1Hypothetical protein. (218 aa)
nfoApurinic endonuclease Apn1; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (277 aa)
nthHhH-GPD family protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (218 aa)
ogtmethylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (180 aa)
AGN26001.1DNA double-strand break repair protein; COG0420 DNA repair exonuclease. (375 aa)
AGN26000.1SMC domain-containing protein; COG0419 ATPase involved in DNA repair. (794 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (313 aa)
radBDNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (221 aa)
ligATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (585 aa)
AGN25908.1Hef nuclease; COG1111 ERCC4-like helicases. (524 aa)
AGN25644.1COG0350 Methylated DNA-protein cysteine methyltransferase. (323 aa)
AGN25634.1Radical SAM protein; COG1533 DNA repair photolyase. (302 aa)
Your Current Organism:
Methanomassiliicoccus intestinalis
NCBI taxonomy Id: 1295009
Other names: C. Methanomassiliicoccus intestinalis Issoire-Mx1, Candidatus Methanomassiliicoccus intestinalis Issoire-Mx1
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