STRINGSTRING
AGN26766.1 AGN26766.1 AGN26727.1 AGN26727.1 AGN26691.1 AGN26691.1 AGN25520.1 AGN25520.1 AGN25563.1 AGN25563.1 AGN25618.1 AGN25618.1 AGN25629.1 AGN25629.1 thiL thiL AGN25706.1 AGN25706.1 AGN25754.1 AGN25754.1 AGN25755.1 AGN25755.1 AGN25756.1 AGN25756.1 AGN25757.1 AGN25757.1 AGN25957.1 AGN25957.1 AGN25980.1 AGN25980.1 AGN26145.1 AGN26145.1 AGN26152.1 AGN26152.1 AGN26200.1 AGN26200.1 AGN26204.1 AGN26204.1 AGN26205.1 AGN26205.1 AGN26206.1 AGN26206.1 AGN26231.1 AGN26231.1 AGN26244.1 AGN26244.1 AGN26245.1 AGN26245.1 AGN26247.1 AGN26247.1 AGN26677.1 AGN26677.1 thiM thiM thiE thiE AGN26579.1 AGN26579.1 AGN26578.1 AGN26578.1 AGN26577.1 AGN26577.1 AGN26576.1 AGN26576.1 vorD vorD AGN26574.1 AGN26574.1 AGN26538.1 AGN26538.1 metAA metAA AGN26469.1 AGN26469.1 AGN26468.1 AGN26468.1 AGN26401.1 AGN26401.1 AGN26262.1 AGN26262.1 thiC thiC AGN27089.1 AGN27089.1 AGN27088.1 AGN27088.1 AGN27087.1 AGN27087.1 AGN27083.1 AGN27083.1 AGY50221.1 AGY50221.1 AGN27066.1 AGN27066.1 thiE-2 thiE-2 thiM-2 thiM-2 AGN26950.1 AGN26950.1 folD folD AGN26905.1 AGN26905.1 mtnP mtnP AGN26767.1 AGN26767.1 AGN26251.1 AGN26251.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGN26766.1Hypothetical protein. (389 aa)
AGN26727.1COG1145 Ferredoxin. (120 aa)
AGN26691.1Hypothetical protein; COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (270 aa)
AGN25520.1Rhodanese domain-containing protein; COG0607 Rhodanese-related sulfurtransferase. (109 aa)
AGN25563.1COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (572 aa)
AGN25618.1Hypothetical protein; COG0301 Thiamine biosynthesis ATP pyrophosphatase. (208 aa)
AGN25629.1COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (279 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (320 aa)
AGN25706.1Hypothetical protein; COG5270 PUA domain (predicted RNA-binding domain). (627 aa)
AGN25754.12-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family protein; COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit. (186 aa)
AGN25755.1COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit. (91 aa)
AGN25756.1Pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit. (388 aa)
AGN25757.1COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (313 aa)
AGN25957.1Metal-dependent hydrolase; COG0402 Cytosine deaminase and related metal-dependent hydrolases. (429 aa)
AGN25980.1COG0857 BioD-like N-terminal domain of phosphotransacetylase. (327 aa)
AGN26145.1COG0192 S-adenosylmethionine synthetase. (414 aa)
AGN26152.1Hypothetical protein; COG5270 PUA domain (predicted RNA-binding domain). (600 aa)
AGN26200.1COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (543 aa)
AGN26204.1Pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit. (353 aa)
AGN26205.1Thiamine pyrophosphate TPP-binding domain-containing protein; COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (251 aa)
AGN26206.1COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit. (178 aa)
AGN26231.1COG1045 Serine acetyltransferase. (215 aa)
AGN26244.1Indolepyruvate oxidoreductase subunit IorB; COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit. (191 aa)
AGN26245.1Indolepyruvate ferredoxin oxidoreductase, alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (589 aa)
AGN26247.1Monomethylamine methyltransferase corrinoid protein; COG5012 Predicted cobalamin binding protein. (218 aa)
AGN26677.1Radical SAM protein; COG0502 Biotin synthase and related enzymes. (326 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (267 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (210 aa)
AGN26579.1Indolepyruvate oxidoreductase subunit beta; COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit. (202 aa)
AGN26578.1Indolepyruvate ferredoxin oxidoreductase, alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (604 aa)
AGN26577.1COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (292 aa)
AGN26576.1COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit. (385 aa)
vorDCOG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit. (89 aa)
AGN26574.12-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family protein; COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit. (186 aa)
AGN26538.1Hypothetical protein; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (575 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (305 aa)
AGN26469.1COG2873 O-acetylhomoserine sulfhydrylase. (427 aa)
AGN26468.1COG0031 Cysteine synthase. (303 aa)
AGN26401.1Radical SAM domain and peroxiredoxin domain containing protein; COG0502 Biotin synthase and related enzymes. (496 aa)
AGN26262.1Dimethylamine methyltransferase corrinoid protein; COG5012 Predicted cobalamin binding protein. (214 aa)
thiCPhosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (424 aa)
AGN27089.1Hypothetical protein. (416 aa)
AGN27088.1Sulfopyruvate decarboxylase subunit beta; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (185 aa)
AGN27087.1Sulfopyruvate decarboxylase subunit alpha; COG4032 Predicted thiamine-pyrophosphate-binding protein. (168 aa)
AGN27083.1COG0498 Threonine synthase. (403 aa)
AGY50221.1COG3959 Transketolase, N-terminal subunit. (278 aa)
AGN27066.1COG3958 Transketolase, C-terminal subunit. (315 aa)
thiE-2Thiamine-phosphate pyrophosphorylase ThiE2; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa)
thiM-2Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (272 aa)
AGN26950.1Translation initiation factor IF-2B subunit alpha; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (335 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa)
AGN26905.1tRNA S(4)U 4-thiouridine synthase (former ThiI); COG0301 Thiamine biosynthesis ATP pyrophosphatase. (285 aa)
mtnP5'-methylthioadenosine phosphorylase II; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (260 aa)
AGN26767.1Ferridoxin; COG1145 Ferredoxin. (134 aa)
AGN26251.1COG0502 Biotin synthase and related enzymes. (360 aa)
Your Current Organism:
Methanomassiliicoccus intestinalis
NCBI taxonomy Id: 1295009
Other names: C. Methanomassiliicoccus intestinalis Issoire-Mx1, Candidatus Methanomassiliicoccus intestinalis Issoire-Mx1
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