(27 nodes) Telomere maintenance network (Cryptococcus amylolentus)

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proteins of unknown 3D structure

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Your Input:
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (656 aa)
	L202_00893	Uncharacterized protein. (237 aa)
	L202_00892	Ku_PK_bind domain-containing protein. (203 aa)
	L202_00683	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (950 aa)
	L202_00705	Ku domain-containing protein. (841 aa)
	L202_00537	HTH APSES-type domain-containing protein. (397 aa)
	L202_00032	Uncharacterized protein. (175 aa)
	L202_00099	Uncharacterized protein. (1337 aa)
	L202_01596	Uncharacterized protein. (384 aa)
	L202_01499	Sua5/YciO/YrdC/YwlC family tRNA threonylcarbamoyl adenosine modification protein. (483 aa)
	L202_02560	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1032 aa)
	KAE1	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (393 aa)
	L202_02111	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (603 aa)
	L202_02904	ATP-dependent DNA helicase; Belongs to the helicase family. (663 aa)
	L202_04360	Uncharacterized protein. (1412 aa)
	L202_04171	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1114 aa)
	L202_04270	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2283 aa)
	L202_05035	HABP4_PAI-RBP1 domain-containing protein. (362 aa)
	L202_07815	Ku domain-containing protein. (749 aa)
	L202_07827	Telomere_reg-2 domain-containing protein. (1105 aa)
	L202_07502	EKC/KEOPS complex subunit CGI121; Belongs to the CGI121/TPRKB family. (226 aa)
	L202_07519	AAA_23 domain-containing protein. (1340 aa)
	L202_06658	Checkpoint protein; Belongs to the HUS1 family. (300 aa)
	L202_06653	ATP-dependent DNA helicase; Belongs to the helicase family. (505 aa)
	L202_06041	Uncharacterized protein. (712 aa)
	L202_05485	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability. (3020 aa)
	L202_04712	DRMBL domain-containing protein. (792 aa)

Your Current Organism:

Cryptococcus amylolentus

NCBI taxonomy Id: 1295533
Other names: C. amylolentus CBS 6039, Cryptococcus amylolentus CBS 6039, Cryptococcus amylolentus CBS6039

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KAE1	L202_01499	A0A1E3I0E2	A0A1E3I471	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	Sua5/YciO/YrdC/YwlC family tRNA threonylcarbamoyl adenosine modification protein.	0.886
KAE1	L202_07502	A0A1E3I0E2	A0A1E3HCH2	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	EKC/KEOPS complex subunit CGI121; Belongs to the CGI121/TPRKB family.	0.996
L202_00032	L202_00099	A0A1E3I640	A0A1E3I628	Uncharacterized protein.	Uncharacterized protein.	0.447
L202_00032	L202_00683	A0A1E3I640	A0A1E3I8V5	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.447
L202_00032	L202_02111	A0A1E3I640	A0A1E3HZL2	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.689
L202_00032	L202_02560	A0A1E3I640	A0A1E3I106	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.461
L202_00032	L202_04171	A0A1E3I640	A0A1E3HQZ5	Uncharacterized protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.709
L202_00032	L202_04270	A0A1E3I640	A0A1E3HQQ2	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.457
L202_00032	L202_04360	A0A1E3I640	A0A1E3HR24	Uncharacterized protein.	Uncharacterized protein.	0.569
L202_00032	L202_07519	A0A1E3I640	A0A1E3HCH9	Uncharacterized protein.	AAA_23 domain-containing protein.	0.526
L202_00032	L202_07815	A0A1E3I640	A0A1E3HA87	Uncharacterized protein.	Ku domain-containing protein.	0.432
L202_00099	L202_00032	A0A1E3I628	A0A1E3I640	Uncharacterized protein.	Uncharacterized protein.	0.447
L202_00099	L202_00705	A0A1E3I628	A0A1E3I8E9	Uncharacterized protein.	Ku domain-containing protein.	0.467
L202_00099	L202_00892	A0A1E3I628	A0A1E3I907	Uncharacterized protein.	Ku_PK_bind domain-containing protein.	0.467
L202_00099	L202_00893	A0A1E3I628	A0A1E3I9J5	Uncharacterized protein.	Uncharacterized protein.	0.467
L202_00099	L202_02111	A0A1E3I628	A0A1E3HZL2	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.969
L202_00099	L202_02560	A0A1E3I628	A0A1E3I106	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.972
L202_00099	L202_02904	A0A1E3I628	A0A1E3HWN8	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family.	0.495
L202_00099	L202_04171	A0A1E3I628	A0A1E3HQZ5	Uncharacterized protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.495
L202_00099	L202_04270	A0A1E3I628	A0A1E3HQQ2	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.940