STRINGSTRING
I206_00927 I206_00927 I206_07587 I206_07587 I206_07699 I206_07699 I206_07530 I206_07530 I206_07560 I206_07560 I206_07244 I206_07244 I206_07254 I206_07254 I206_06891 I206_06891 I206_07068 I206_07068 I206_06237 I206_06237 COQ3 COQ3 COQ7 COQ7 I206_06393 I206_06393 I206_06405 I206_06405 I206_06426 I206_06426 I206_06530 I206_06530 I206_05871 I206_05871 I206_05921 I206_05921 I206_05193 I206_05193 I206_05292 I206_05292 I206_05293 I206_05293 I206_05340 I206_05340 I206_05447 I206_05447 I206_05465 I206_05465 I206_05549 I206_05549 COQ6 COQ6 I206_04830 I206_04830 I206_04938 I206_04938 I206_04922 I206_04922 I206_05011 I206_05011 I206_05027 I206_05027 COQ5 COQ5 I206_04294 I206_04294 I206_00916 I206_00916 I206_04308 I206_04308 I206_04342 I206_04342 I206_04492 I206_04492 I206_03387 I206_03387 I206_03607 I206_03607 I206_03681 I206_03681 I206_03732 I206_03732 I206_03836 I206_03836 I206_03931 I206_03931 I206_03935 I206_03935 I206_02830 I206_02830 I206_02895 I206_02895 I206_02879 I206_02879 I206_02901 I206_02901 I206_03030 I206_03030 I206_03095 I206_03095 I206_03108 I206_03108 I206_03171 I206_03171 I206_03277 I206_03277 I206_02137 I206_02137 I206_02125 I206_02125 I206_02443 I206_02443 I206_01440 I206_01440 I206_01572 I206_01572 I206_01624 I206_01624 I206_01745 I206_01745 I206_01798 I206_01798 I206_00011 I206_00011 I206_00280 I206_00280 I206_00129 I206_00129 I206_00337 I206_00337 I206_00335 I206_00335 I206_00342 I206_00342 I206_00475 I206_00475 I206_00833 I206_00833 I206_00868 I206_00868 I206_01065 I206_01065 I206_01076 I206_01076 I206_00999 I206_00999 I206_01019 I206_01019
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I206_00927Hsp90-like protein. (698 aa)
I206_07587Type I phosphodiesterase/nucleotide pyrophosphatase. (563 aa)
I206_07699Riboflavin kinase. (198 aa)
I206_07530Solute carrier family 25 (Mitochondrial folate transporter), member 32; Belongs to the mitochondrial carrier (TC 2.A.29) family. (418 aa)
I206_07560Acetyl-CoA carboxylase, biotin carboxylase subunit. (756 aa)
I206_07244Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (644 aa)
I206_07254RIBOSOMAL_L9 domain-containing protein. (218 aa)
I206_06891DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (225 aa)
I206_07068Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (476 aa)
I206_06237NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (251 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (356 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (253 aa)
I206_06393Adenylyltransferase and sulfurtransferase. (423 aa)
I206_06405NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (753 aa)
I206_06426Uncharacterized protein. (828 aa)
I206_06530Cysteine desulfurase IscS. (500 aa)
I206_05871Molybdopterin binding domain-containing protein. (302 aa)
I206_05921Hexaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. (498 aa)
I206_05193Uncharacterized protein. (803 aa)
I206_05292THF_DHG_CYH domain-containing protein. (108 aa)
I206_05293THF_DHG_CYH_C domain-containing protein. (113 aa)
I206_05340Flavin_Reduct domain-containing protein. (350 aa)
I206_05447Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1218 aa)
I206_05465Nicotinate (Nicotinamide) nucleotide adenylyltransferase. (574 aa)
I206_05549Acetyl-CoA carboxylase/biotin carboxylase. (2234 aa)
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (620 aa)
I206_04830NAD+ kinase. (1191 aa)
I206_04938Nicotinamide riboside kinase. (262 aa)
I206_04922Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (231 aa)
I206_05011Uncharacterized protein. (883 aa)
I206_05027Uncharacterized protein. (233 aa)
COQ52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (334 aa)
I206_04294Flavoprotein domain-containing protein. (336 aa)
I206_00916Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (319 aa)
I206_04308ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (333 aa)
I206_04342Pyridoxal kinase. (393 aa)
I206_04492Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (640 aa)
I206_03387Amino_oxidase domain-containing protein. (666 aa)
I206_03607Phosphopantothenate-cysteine ligase. (381 aa)
I206_03681NAD+ diphosphatase. (393 aa)
I206_03732Cytoplasmic protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa)
I206_03836Methylenetetrahydrofolate dehydrogenase (NADP). (1021 aa)
I206_03931Uncharacterized protein. (316 aa)
I206_03935Solute carrier family 25 (Mitochondrial folate transporter), member 32; Belongs to the mitochondrial carrier (TC 2.A.29) family. (339 aa)
I206_02830LRP16 family protein. (213 aa)
I206_02895FSH1 domain-containing protein. (269 aa)
I206_02879Solute carrier family 25 (Mitochondrial phosphate transporter), member 23/24/25/41; Belongs to the mitochondrial carrier (TC 2.A.29) family. (384 aa)
I206_02901Biotin-[acetyl-CoA-carboxylase] ligase. (782 aa)
I206_03030BZIP domain-containing protein. (640 aa)
I206_030954-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (403 aa)
I206_03108Acetyl/propionyl CoA carboxylase. (594 aa)
I206_03171Pyridoxamine 5'-phosphate oxidase. (250 aa)
I206_03277Cytochrome b5; Belongs to the cytochrome b5 family. (140 aa)
I206_02137Vacuolar membrane protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (475 aa)
I206_02125Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (452 aa)
I206_02443Vacuolar protein. (601 aa)
I206_01440Uncharacterized protein. (246 aa)
I206_01572CTP_transf_like domain-containing protein. (360 aa)
I206_01624Uncharacterized protein. (703 aa)
I206_01745Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (426 aa)
I206_01798GTP cyclohydrolase I. (438 aa)
I206_000115-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (231 aa)
I206_00280Solute carrier family 25 (Mitochondrial carrier protein), member 16; Belongs to the mitochondrial carrier (TC 2.A.29) family. (379 aa)
I206_00129Lipase_GDSL domain-containing protein. (443 aa)
I206_00337Nudix hydrolase domain-containing protein. (366 aa)
I206_00335Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (712 aa)
I206_00342Uncharacterized protein. (400 aa)
I206_00475FMN adenylyltransferase. (299 aa)
I206_00833Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (302 aa)
I206_00868Dephospho-CoA kinase. (298 aa)
I206_01065Pantothenate kinase. (520 aa)
I206_01076Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (485 aa)
I206_00999NADH kinase. (399 aa)
I206_01019MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (457 aa)
Your Current Organism:
Kwoniella pini
NCBI taxonomy Id: 1296096
Other names: Cryptococcus pinus CBS 10737, Cryptococcus pinus CBS10737, K. pini CBS 10737, Kwoniella pini CBS 10737
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