87 items (Kwoniella bestiolae) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	I302_08905	DNA polymerase. (1981 aa)
	I302_08997	ERCC4 domain-containing protein. (840 aa)
	I302_09050	DNA helicase; Belongs to the MCM family. (961 aa)
	I302_09111	3'-5' exonuclease domain-containing protein. (270 aa)
	I302_09113	3'-5' exonuclease domain-containing protein. (287 aa)
	I302_09144	DNA helicase; Belongs to the MCM family. (736 aa)
	I302_08567	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (903 aa)
	I302_08576	Ku domain-containing protein. (850 aa)
	I302_08584	Uncharacterized protein. (948 aa)
	I302_08709	Uncharacterized protein. (583 aa)
	I302_08778	Uncharacterized protein. (844 aa)
	I302_07766	DNA repair protein Swi5/Sae3. (104 aa)
	I302_07795	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (388 aa)
	I302_07913	Cell division control protein 45. (712 aa)
	I302_07990	DNA_LIGASE_A3 domain-containing protein. (945 aa)
	I302_08143	Uncharacterized protein. (992 aa)
	I302_08236	Meiotic Sister-Chromatid recombination aldehyde dehydrogenase. (634 aa)
	I302_08280	RING-type domain-containing protein. (476 aa)
	I302_07406	DNA ligase. (816 aa)
	I302_07429	Ku domain-containing protein. (751 aa)
	I302_07453	Mitochondrial genome maintenance protein. (335 aa)
	I302_07615	Uncharacterized protein. (957 aa)
	I302_06461	DNA mismatch repair protein MLH1. (712 aa)
	I302_06465	Deacetylase sirtuin-type domain-containing protein. (466 aa)
	I302_06619	Endonuclease. (365 aa)
	I302_06691	DUF1767 domain-containing protein. (561 aa)
	I302_06852	DNA replication complex GINS protein PSF1. (230 aa)
	I302_06947	DNA helicase; Belongs to the MCM family. (934 aa)
	I302_05634	WD_REPEATS_REGION domain-containing protein. (1244 aa)
	I302_05671	26S proteasome complex subunit DSS1. (107 aa)
	I302_05736	DNA repair protein RAD50. (1357 aa)
	I302_05781	Helicase C-terminal domain-containing protein. (194 aa)
	I302_05843	Replication factor A2. (256 aa)
	I302_05897	SMC_N domain-containing protein. (1155 aa)
	I302_06043	DNA repair and recombination protein RAD54-like protein. (817 aa)
	I302_06133	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (612 aa)
	I302_06132	SP-RING-type domain-containing protein. (313 aa)
	I302_06193	SMC_N domain-containing protein. (1165 aa)
	I302_04726	Uncharacterized protein. (1424 aa)
	I302_04734	DNA helicase; Belongs to the MCM family. (868 aa)
	I302_04778	TP6A_N domain-containing protein. (688 aa)
	I302_04912	AAA domain-containing protein. (1021 aa)
	I302_05132	Deacetylase sirtuin-type domain-containing protein. (567 aa)
	KAE1	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (380 aa)
	I302_05208	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1495 aa)
	I302_05210	AAA domain-containing protein. (379 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (330 aa)
	I302_05231	DNA_MISMATCH_REPAIR_2 domain-containing protein. (850 aa)
	I302_03810	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (971 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (428 aa)
	I302_04095	Uncharacterized protein. (637 aa)
	I302_04154	Uncharacterized protein. (348 aa)
	I302_04634	SWIM-type domain-containing protein. (248 aa)
	I302_04672	Uncharacterized protein. (580 aa)
	I302_01864	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1158 aa)
	I302_02030	Serine/threonine-protein phosphatase. (308 aa)
	I302_02179	Checkpoint protein; Belongs to the HUS1 family. (294 aa)
	I302_02190	PLK/PLK1 protein kinase. (795 aa)
	I302_02336	Uncharacterized protein. (348 aa)
	I302_02298	Helicase. (883 aa)
	I302_02384	RECA_2 domain-containing protein. (582 aa)
	I302_02436	TBPIP domain-containing protein. (279 aa)
	I302_02488	DNA ligase. (1084 aa)
	I302_02525	AAA domain-containing protein; Belongs to the AAA ATPase family. (584 aa)
	I302_02594	ERCC4 domain-containing protein. (595 aa)
	I302_02772	Meiotic nuclear division protein 1; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (204 aa)
	I302_02774	zf-RING-like domain-containing protein. (365 aa)
	I302_02879	Uncharacterized protein. (1259 aa)
	I302_02896	Uncharacterized protein. (1087 aa)
	I302_02960	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (199 aa)
	I302_03303	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1021 aa)
	I302_00208	DNA excision repair protein ERCC-1. (377 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (794 aa)
	I302_00404	DNA excision repair protein ERCC-4. (1128 aa)
	I302_00679	Uncharacterized protein. (309 aa)
	I302_00726	Uncharacterized protein. (703 aa)
	I302_00691	DNA ligase 1. (1010 aa)
	I302_00775	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1201 aa)
	I302_00895	Uncharacterized protein; Belongs to the CGI121/TPRKB family. (225 aa)
	I302_01142	Uncharacterized protein. (218 aa)
	I302_01327	Uncharacterized protein. (1454 aa)
	I302_01345	Meiotic recombinase Dmc1; Belongs to the RecA family. (333 aa)
	I302_01324	DNA helicase; Belongs to the MCM family. (997 aa)
	I302_01471	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (344 aa)
	I302_01575	DUF3421 domain-containing protein. (396 aa)
	I302_01621	DNA mismatch repair protein MSH2; Component of the post-replicative DNA mismatch repair system (MMR). (964 aa)
	I302_01553	CDC7 protein kinase. (898 aa)

Your Current Organism:

Kwoniella bestiolae

NCBI taxonomy Id: 1296100
Other names: Cryptococcus bestiolae CBS 10118, Cryptococcus bestiolae CBS10118, K. bestiolae CBS 10118, Kwoniella bestiolae CBS 10118

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	I302_00208	A0A1B9G5N2	A0A1B9GCH4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA excision repair protein ERCC-1.	0.838
FEN1	I302_00404	A0A1B9G5N2	A0A1B9GD17	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA excision repair protein ERCC-4.	0.812
FEN1	I302_00691	A0A1B9G5N2	A0A1B9GDZ1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase 1.	0.968
FEN1	I302_00775	A0A1B9G5N2	A0A1B9GE21	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.826
FEN1	I302_01324	A0A1B9G5N2	A0A1B9GFS4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.894
FEN1	I302_01327	A0A1B9G5N2	A0A1B9GFI6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.878
FEN1	I302_01345	A0A1B9G5N2	A0A1B9GFL2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Meiotic recombinase Dmc1; Belongs to the RecA family.	0.726
FEN1	I302_01471	A0A1B9G5N2	A0A1B9GG16	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.939
FEN1	I302_01621	A0A1B9G5N2	A0A1B9GGB5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA mismatch repair protein MSH2; Component of the post-replicative DNA mismatch repair system (MMR).	0.918
FEN1	I302_01864	A0A1B9G5N2	A0A1B9G7M2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.753
FEN1	I302_02030	A0A1B9G5N2	A0A1B9G849	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Serine/threonine-protein phosphatase.	0.482
FEN1	I302_02179	A0A1B9G5N2	A0A1B9G8I3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Checkpoint protein; Belongs to the HUS1 family.	0.858
FEN1	I302_02298	A0A1B9G5N2	A0A1B9G8X0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Helicase.	0.649
FEN1	I302_02384	A0A1B9G5N2	A0A1B9G938	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	RECA_2 domain-containing protein.	0.869
FEN1	I302_02488	A0A1B9G5N2	A0A1B9G9C9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.843
FEN1	I302_02525	A0A1B9G5N2	A0A1B9G9K8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.431
FEN1	I302_02594	A0A1B9G5N2	A0A1B9G9P2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ERCC4 domain-containing protein.	0.506
FEN1	I302_02879	A0A1B9G5N2	A0A1B9GAI8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.902
FEN1	I302_02896	A0A1B9G5N2	A0A1B9GAL4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.685
FEN1	I302_02960	A0A1B9G5N2	A0A1B9GAS3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	0.548