STRINGSTRING
I303_08521 I303_08521 I303_08193 I303_08193 I303_08219 I303_08219 I303_08238 I303_08238 I303_07648 I303_07648 I303_07727 I303_07727 I303_07313 I303_07313 I303_07511 I303_07511 I303_07536 I303_07536 I303_06759 I303_06759 I303_05704 I303_05704 I303_05776 I303_05776 NCS6 NCS6 I303_05945 I303_05945 I303_04924 I303_04924 I303_05031 I303_05031 I303_05172 I303_05172 I303_05470 I303_05470 I303_04410 I303_04410 I303_04476 I303_04476 I303_04577 I303_04577 I303_03402 I303_03402 I303_03469 I303_03469 I303_03930 I303_03930 I303_02649 I303_02649 I303_02659 I303_02659 I303_02749 I303_02749 I303_03256 I303_03256 I303_01729 I303_01729 I303_01918 I303_01918 I303_02001 I303_02001 I303_02069 I303_02069 I303_02259 I303_02259 I303_02282 I303_02282 I303_02326 I303_02326 I303_02367 I303_02367 I303_00213 I303_00213 I303_00393 I303_00393 ADK1 ADK1 I303_00502 I303_00502 I303_00820 I303_00820 I303_00834 I303_00834 I303_01022 I303_01022 I303_01042 I303_01042 I303_01092 I303_01092 I303_01146 I303_01146 I303_01147 I303_01147 I303_01279 I303_01279 I303_01280 I303_01280
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I303_08521Uncharacterized protein. (794 aa)
I303_08193Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (308 aa)
I303_08219Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (928 aa)
I303_08238tRNA-specific adenosine deaminase 2. (278 aa)
I303_07648PfkB domain-containing protein. (479 aa)
I303_077272,5-diamino-6-(Ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase. (251 aa)
I303_07313Nucleoside diphosphate kinase. (152 aa)
I303_07511Transferase. (218 aa)
I303_07536Ribonucleoside-diphosphate reductase subunit M2. (435 aa)
I303_06759Nicotinamide riboside kinase. (258 aa)
I303_05704Uncharacterized protein. (2172 aa)
I303_05776Hydrolase. (425 aa)
NCS6Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (361 aa)
I303_05945Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (861 aa)
I303_04924Glutamine amidotransferase type-1 domain-containing protein. (294 aa)
I303_05031Guanine deaminase. (476 aa)
I303_05172Vacuolar protein. (607 aa)
I303_05470HD domain-containing protein. (410 aa)
I303_04410Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (196 aa)
I303_04476CBS and PB1 domain-containing protein. (797 aa)
I303_04577S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (311 aa)
I303_03402Uncharacterized protein. (259 aa)
I303_03469Guanosine-diphosphatase; Belongs to the GDA1/CD39 NTPase family. (731 aa)
I303_03930dCMP deaminase. (377 aa)
I303_02649Uncharacterized protein. (714 aa)
I303_02659Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (196 aa)
I303_02749YbgI/family dinuclear metal center protein. (289 aa)
I303_03256CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (636 aa)
I303_01729Uncharacterized protein. (619 aa)
I303_01918Adenylate kinase; Belongs to the adenylate kinase family. (425 aa)
I303_02001Nucleoside-diphosphate kinase; Belongs to the NDK family. (222 aa)
I303_02069Glutaredoxin. (100 aa)
I303_02259Adenine phosphoribosyltransferase. (180 aa)
I303_02282HD domain-containing protein. (277 aa)
I303_02326Adenosine kinase. (355 aa)
I303_02367Uncharacterized protein. (410 aa)
I303_00213Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (554 aa)
I303_00393Ribonucleoside-diphosphate reductase small subunit. (398 aa)
ADK1Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (332 aa)
I303_00502PfkB domain-containing protein. (393 aa)
I303_00820GMP synthase [glutamine-hydrolyzing]. (551 aa)
I303_00834Guanylate kinase. (217 aa)
I303_01022dUTP pyrophosphatase. (172 aa)
I303_01042Uncharacterized protein. (680 aa)
I303_01092Thymidylate kinase. (220 aa)
I303_01146Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (170 aa)
I303_01147Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (397 aa)
I303_01279AMP deaminase. (861 aa)
I303_01280Uncharacterized protein. (257 aa)
Your Current Organism:
Kwoniella dejecticola
NCBI taxonomy Id: 1296121
Other names: Cryptococcus dejecticola CBS 10117, K. dejecticola CBS 10117, Kwoniella dejecticola CBS 10117
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