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I303_03496 I303_03496 I303_08446 I303_08446 I303_08670 I303_08670 I303_07570 I303_07570 I303_07609 I303_07609 I303_06450 I303_06450 I303_05691 I303_05691 I303_05775 I303_05775 NCS6 NCS6 I303_06317 I303_06317 I303_05281 I303_05281 URM1 URM1 I303_04301 I303_04301 I303_04714 I303_04714 CFD1 CFD1 I303_04098 I303_04098 I303_02902 I303_02902 I303_03036 I303_03036 NCS2 NCS2 I303_02085 I303_02085 I303_02213 I303_02213 I303_00598 I303_00598 I303_00753 I303_00753 I303_00861 I303_00861
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I303_03496Elongator complex protein 2. (780 aa)
I303_08446Uncharacterized protein. (293 aa)
I303_08670Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1326 aa)
I303_07570tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase. (472 aa)
I303_07609NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (297 aa)
I303_06450Uncharacterized protein. (479 aa)
I303_05691Methyltransf_25 domain-containing protein. (294 aa)
I303_05775Uncharacterized protein. (381 aa)
NCS6Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (361 aa)
I303_06317Methyltransf_11 domain-containing protein. (427 aa)
I303_05281Thiosulfate/3-mercaptopyruvate sulfurtransferase. (334 aa)
URM1Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] (146 aa)
I303_04301Diphthamide biosynthesis protein 3. (155 aa)
I303_04714NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex 4. (92 aa)
CFD1Cytosolic Fe-S cluster assembly factor CFD1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (353 aa)
I303_04098Uncharacterized protein. (322 aa)
I303_02902DPBB_1 domain-containing protein. (296 aa)
I303_03036Uncharacterized protein. (552 aa)
NCS2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (531 aa)
I303_02085Adenylyltransferase and sulfurtransferase. (432 aa)
I303_02213Cysteine desulfurase IscS. (500 aa)
I303_00598Protein KTI12. (304 aa)
I303_00753Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (556 aa)
I303_00861Uncharacterized protein. (286 aa)
Your Current Organism:
Kwoniella dejecticola
NCBI taxonomy Id: 1296121
Other names: Cryptococcus dejecticola CBS 10117, K. dejecticola CBS 10117, Kwoniella dejecticola CBS 10117
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