STRINGSTRING
I303_03496 I303_03496 I303_08418 I303_08418 I303_08446 I303_08446 I303_08670 I303_08670 ALA1 ALA1 I303_08238 I303_08238 I303_07570 I303_07570 I303_07609 I303_07609 I303_07801 I303_07801 I303_07820 I303_07820 I303_07822 I303_07822 I303_07839 I303_07839 I303_07871 I303_07871 I303_07044 I303_07044 I303_07121 I303_07121 I303_07125 I303_07125 TRM5 TRM5 I303_07180 I303_07180 I303_07221 I303_07221 I303_07284 I303_07284 I303_07325 I303_07325 I303_07433 I303_07433 I303_07463 I303_07463 I303_06450 I303_06450 I303_06691 I303_06691 I303_06799 I303_06799 I303_06815 I303_06815 I303_06950 I303_06950 I303_05676 I303_05676 I303_05691 I303_05691 I303_05775 I303_05775 NCS6 NCS6 I303_05848 I303_05848 I303_05876 I303_05876 I303_05904 I303_05904 I303_06042 I303_06042 TRM82 TRM82 I303_06317 I303_06317 I303_04970 I303_04970 I303_05046 I303_05046 NAT10 NAT10 I303_05281 I303_05281 I303_05308 I303_05308 I303_05368 I303_05368 I303_05547 I303_05547 I303_05568 I303_05568 I303_04192 I303_04192 URM1 URM1 I303_04301 I303_04301 I303_04317 I303_04317 KAE1 KAE1 I303_04537 I303_04537 I303_04611 I303_04611 I303_04641 I303_04641 I303_04714 I303_04714 I303_04747 I303_04747 CFD1 CFD1 I303_03439 I303_03439 I303_03457 I303_03457 I303_03584 I303_03584 SPB1 SPB1 I303_03742 I303_03742 I303_03798 I303_03798 TRM8 TRM8 I303_04068 I303_04068 I303_04098 I303_04098 I303_02466 I303_02466 I303_02468 I303_02468 I303_02467 I303_02467 I303_02478 I303_02478 I303_02649 I303_02649 I303_02797 I303_02797 I303_02795 I303_02795 I303_02789 I303_02789 I303_02902 I303_02902 TSR3 TSR3 I303_02980 I303_02980 I303_03036 I303_03036 I303_03089 I303_03089 NCS2 NCS2 I303_01536 I303_01536 I303_01567 I303_01567 I303_01569 I303_01569 I303_01630 I303_01630 I303_01680 I303_01680 I303_01910 I303_01910 I303_02033 I303_02033 I303_02085 I303_02085 I303_02213 I303_02213 I303_00239 I303_00239 I303_00350 I303_00350 I303_00598 I303_00598 I303_00682 I303_00682 I303_00689 I303_00689 I303_00707 I303_00707 I303_00753 I303_00753 I303_00758 I303_00758 I303_00830 I303_00830 I303_00826 I303_00826 I303_00861 I303_00861 I303_00838 I303_00838 I303_00930 I303_00930 I303_01020 I303_01020 I303_01042 I303_01042 I303_01385 I303_01385
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I303_03496Elongator complex protein 2. (780 aa)
I303_08418AAA domain-containing protein. (265 aa)
I303_08446Uncharacterized protein. (293 aa)
I303_08670Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1326 aa)
ALA1Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (977 aa)
I303_08238tRNA-specific adenosine deaminase 2. (278 aa)
I303_07570tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase. (472 aa)
I303_07609NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (297 aa)
I303_07801tRNA (Adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6. (577 aa)
I303_07820BTB domain-containing protein. (266 aa)
I303_07822BTB domain-containing protein. (218 aa)
I303_07839BTB domain-containing protein. (246 aa)
I303_07871tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (318 aa)
I303_07044Uncharacterized protein. (884 aa)
I303_07121DUF2428 domain-containing protein. (1456 aa)
I303_07125Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16. (1319 aa)
TRM5tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (490 aa)
I303_07180Uncharacterized protein. (774 aa)
I303_07221tRNA-dihydrouridine synthase 2. (446 aa)
I303_07284Uncharacterized protein. (401 aa)
I303_07325Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (237 aa)
I303_07433Uncharacterized protein. (825 aa)
I303_07463Cytoplasmic protein. (459 aa)
I303_06450Uncharacterized protein. (479 aa)
I303_06691H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (215 aa)
I303_06799DUF2431 domain-containing protein. (412 aa)
I303_06815A to I editase domain-containing protein. (483 aa)
I303_06950SGL domain-containing protein. (394 aa)
I303_05676Uncharacterized protein. (480 aa)
I303_05691Methyltransf_25 domain-containing protein. (294 aa)
I303_05775Uncharacterized protein. (381 aa)
NCS6Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (361 aa)
I303_05848mRNA methyltransferase; Belongs to the MT-A70-like family. (288 aa)
I303_05876Methionyl-tRNA formyltransferase. (430 aa)
I303_05904Nuclear protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (588 aa)
I303_06042THUMP domain-containing protein. (433 aa)
TRM82tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (591 aa)
I303_06317Methyltransf_11 domain-containing protein. (427 aa)
I303_04970tRNA pseudouridine(38-40) synthase. (571 aa)
I303_05046Mitochondrial protein. (474 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1065 aa)
I303_05281Thiosulfate/3-mercaptopyruvate sulfurtransferase. (334 aa)
I303_05308Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family. (448 aa)
I303_05368tRNA pseudouridine(55) synthase. (504 aa)
I303_05547H/ACA ribonucleoprotein complex subunit 3. (64 aa)
I303_05568DRAP deaminase. (561 aa)
I303_04192tRNA pseudouridine(38-40) synthase. (587 aa)
URM1Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] (146 aa)
I303_04301Diphthamide biosynthesis protein 3. (155 aa)
I303_04317tRNA dimethylallyltransferase. (549 aa)
KAE1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (380 aa)
I303_04537Uncharacterized protein. (467 aa)
I303_04611tRNA-dihydrouridine synthase 4. (423 aa)
I303_04641Bud site selection protein. (277 aa)
I303_04714NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex 4. (92 aa)
I303_04747N2,N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (692 aa)
CFD1Cytosolic Fe-S cluster assembly factor CFD1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (353 aa)
I303_03439Ribosomal RNA large subunit methyltransferase J. (289 aa)
I303_03457Uncharacterized protein. (359 aa)
I303_03584Sua5/YciO/YrdC/YwlC family protein. (500 aa)
SPB1AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (924 aa)
I303_03742rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (555 aa)
I303_03798Ribosomal RNA methyltransferase Nop2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (722 aa)
TRM8tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (298 aa)
I303_04068tRNA-dihydrouridine(47) synthase [NAD(P)(+)]; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. (751 aa)
I303_04098Uncharacterized protein. (322 aa)
I303_02466Uncharacterized protein. (532 aa)
I303_02468Uncharacterized protein. (100 aa)
I303_02467Uncharacterized protein. (179 aa)
I303_02478tRNA (Adenine-N(1)-)-methyltransferase catalytic subunit TRM61. (448 aa)
I303_02649Uncharacterized protein. (714 aa)
I303_02797mRNA cap 0 methyltransferase domain-containing protein. (875 aa)
I303_02795Multifunctional methyltransferase subunit TRM112. (126 aa)
I303_02789tRNA pseudouridine(55) synthase. (479 aa)
I303_02902DPBB_1 domain-containing protein. (296 aa)
TSR3Ribosome biogenesis protein TSR3; Ribosome biogenesis protein required for processing 35S pre- rRNA at site D; Belongs to the TSR3 family. (344 aa)
I303_02980Uncharacterized protein; Belongs to the CGI121/TPRKB family. (235 aa)
I303_03036Uncharacterized protein. (552 aa)
I303_03089SAM-dependent MTase TRM10-type domain-containing protein. (415 aa)
NCS2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (531 aa)
I303_01536tRNA (Uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (606 aa)
I303_01567BTB domain-containing protein. (198 aa)
I303_01569BTB domain-containing protein. (207 aa)
I303_01630Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (410 aa)
I303_01680Nucleolar essential protein 1. (362 aa)
I303_01910Multisite-specific tRNA:(Cytosine-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (704 aa)
I303_02033rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (314 aa)
I303_02085Adenylyltransferase and sulfurtransferase. (432 aa)
I303_02213Cysteine desulfurase IscS. (500 aa)
I303_00239tRNA-dihydrouridine synthase 1. (592 aa)
I303_00350tRNA pseudouridine13 synthase. (941 aa)
I303_00598Protein KTI12. (304 aa)
I303_00682rRNA 2'-O-methyltransferase fibrillarin. (327 aa)
I303_00689CAMK protein kinase. (1194 aa)
I303_00707tRNA (Guanine10-N2)-methyltransferase. (476 aa)
I303_00753Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (556 aa)
I303_00758F-box domain-containing protein. (328 aa)
I303_00830Uncharacterized protein. (156 aa)
I303_00826Uncharacterized protein. (670 aa)
I303_00861Uncharacterized protein. (286 aa)
I303_00838tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (422 aa)
I303_00930Uncharacterized protein. (541 aa)
I303_01020Alkylated DNA repair protein AlkB. (439 aa)
I303_01042Uncharacterized protein. (680 aa)
I303_01385SGNH_hydro domain-containing protein. (453 aa)
Your Current Organism:
Kwoniella dejecticola
NCBI taxonomy Id: 1296121
Other names: Cryptococcus dejecticola CBS 10117, K. dejecticola CBS 10117, Kwoniella dejecticola CBS 10117
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