(57 nodes) Glutathione metabolism network (Kwoniella dejecticola)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I303_03661	Glutaredoxin domain-containing protein. (479 aa)
	I303_08438	LigB domain-containing protein. (307 aa)
	I303_08504	Uncharacterized protein. (960 aa)
	I303_08069	Uncharacterized protein; Belongs to the GST superfamily. (373 aa)
	I303_08088	Uncharacterized protein. (1308 aa)
	I303_07213	Mitochondrial protein. (365 aa)
	I303_07347	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (469 aa)
	I303_07456	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (181 aa)
	I303_07536	Ribonucleoside-diphosphate reductase subunit M2. (435 aa)
	I303_06393	Glutathione S-transferase; Belongs to the GST superfamily. (264 aa)
	I303_06844	Gamma-glutamyltransferase. (585 aa)
	I303_06926	Uncharacterized protein. (1333 aa)
	I303_05667	Uncharacterized protein. (223 aa)
	I303_05851	Peroxidase; Belongs to the peroxidase family. (314 aa)
	I303_05945	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (861 aa)
	I303_05943	Uncharacterized protein. (409 aa)
	I303_05987	YTH domain-containing protein. (735 aa)
	I303_06001	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (499 aa)
	I303_06156	Spermidine synthase; Belongs to the spermidine/spermine synthase family. (752 aa)
	I303_06330	Uncharacterized protein. (383 aa)
	I303_04988	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (151 aa)
	I303_05066	Glutamate-cysteine ligase catalytic subunit. (682 aa)
	I303_05317	Peroxidase; Belongs to the peroxidase family. (374 aa)
	I303_05589	5-oxoprolinase (ATP-hydrolysing). (1304 aa)
	I303_04434	Uncharacterized protein. (191 aa)
	I303_04459	Solute carrier family 35 (UDP-sugar transporter), member A1/2/3. (594 aa)
	I303_04568	Glutamate carboxypeptidase. (479 aa)
	I303_04639	Uncharacterized protein. (268 aa)
	I303_04798	Uncharacterized protein. (157 aa)
	I303_03358	5-oxoprolinase (ATP-hydrolysing). (1308 aa)
	I303_03386	Glutaredoxin. (540 aa)
	I303_03508	Aminopeptidase. (920 aa)
	I303_03532	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (430 aa)
	I303_02505	Uncharacterized protein. (917 aa)
	I303_02627	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (198 aa)
	I303_02987	Sphingolipid C9-methyltransferase. (502 aa)
	I303_03215	Uncharacterized protein. (116 aa)
	I303_03224	Uncharacterized protein. (367 aa)
	I303_01873	Glutathione synthetase. (522 aa)
	I303_01890	Fe2OG dioxygenase domain-containing protein. (229 aa)
	I303_01891	Uncharacterized protein. (86 aa)
	I303_01936	Uncharacterized protein. (241 aa)
	I303_02069	Glutaredoxin. (100 aa)
	I303_02125	Gamma-glutamyltransferase. (734 aa)
	I303_00382	Prefoldin, alpha subunit. (153 aa)
	I303_00393	Ribonucleoside-diphosphate reductase small subunit. (398 aa)
	I303_00578	Glutathione S-transferase. (151 aa)
	I303_00677	Uncharacterized protein. (791 aa)
	I303_00716	Thiol-specific antioxidant protein 3. (225 aa)
	I303_00771	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (492 aa)
	I303_01094	Glutaredoxin domain-containing protein. (496 aa)
	I303_01127	Ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (537 aa)
	I303_01174	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (522 aa)
	I303_01189	Cytoplasmic protein. (593 aa)
	I303_01188	Cytoplasmic protein. (769 aa)
	I303_01301	Gamma-glutamyltransferase. (590 aa)
	I303_01435	Glutathione S-transferase; Belongs to the GST superfamily. (278 aa)

Your Current Organism:

Kwoniella dejecticola

NCBI taxonomy Id: 1296121
Other names: Cryptococcus dejecticola CBS 10117, K. dejecticola CBS 10117, Kwoniella dejecticola CBS 10117

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I303_00382	I303_00716	A0A1A6AER6	A0A1A6AFU4	Prefoldin, alpha subunit.	Thiol-specific antioxidant protein 3.	0.619
I303_00382	I303_02627	A0A1A6AER6	A0A1A6A984	Prefoldin, alpha subunit.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.571
I303_00382	I303_07347	A0A1A6AER6	A0A1A5ZXQ7	Prefoldin, alpha subunit.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.669
I303_00393	I303_00716	A0A1A6AEU0	A0A1A6AFU4	Ribonucleoside-diphosphate reductase small subunit.	Thiol-specific antioxidant protein 3.	0.529
I303_00393	I303_04988	A0A1A6AEU0	A0A1A6A240	Ribonucleoside-diphosphate reductase small subunit.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.501
I303_00393	I303_05945	A0A1A6AEU0	A0A1A6A0R7	Ribonucleoside-diphosphate reductase small subunit.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.999
I303_00393	I303_07456	A0A1A6AEU0	A0A1A5ZY02	Ribonucleoside-diphosphate reductase small subunit.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.502
I303_00393	I303_07536	A0A1A6AEU0	A0A1A5ZY85	Ribonucleoside-diphosphate reductase small subunit.	Ribonucleoside-diphosphate reductase subunit M2.	0.775
I303_00578	I303_00716	A0A1A6AFC6	A0A1A6AFU4	Glutathione S-transferase.	Thiol-specific antioxidant protein 3.	0.794
I303_00578	I303_01301	A0A1A6AFC6	A0A1A6AHD4	Glutathione S-transferase.	Gamma-glutamyltransferase.	0.759
I303_00578	I303_01936	A0A1A6AFC6	A0A1A6ACE1	Glutathione S-transferase.	Uncharacterized protein.	0.800
I303_00578	I303_02125	A0A1A6AFC6	A0A1A6ACX8	Glutathione S-transferase.	Gamma-glutamyltransferase.	0.783
I303_00578	I303_02627	A0A1A6AFC6	A0A1A6A984	Glutathione S-transferase.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.791
I303_00578	I303_02987	A0A1A6AFC6	A0A1A6AA84	Glutathione S-transferase.	Sphingolipid C9-methyltransferase.	0.806
I303_00578	I303_04434	A0A1A6AFC6	A0A1A6A501	Glutathione S-transferase.	Uncharacterized protein.	0.824
I303_00578	I303_04459	A0A1A6AFC6	A0A1A6A526	Glutathione S-transferase.	Solute carrier family 35 (UDP-sugar transporter), member A1/2/3.	0.567
I303_00578	I303_04988	A0A1A6AFC6	A0A1A6A240	Glutathione S-transferase.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.705
I303_00578	I303_06330	A0A1A6AFC6	A0A1A6A1V4	Glutathione S-transferase.	Uncharacterized protein.	0.443
I303_00578	I303_06393	A0A1A6AFC6	A0A1A5ZYE8	Glutathione S-transferase.	Glutathione S-transferase; Belongs to the GST superfamily.	0.619
I303_00578	I303_07213	A0A1A6AFC6	A0A1A5ZXC4	Glutathione S-transferase.	Mitochondrial protein.	0.613