STRINGSTRING
URM1 URM1 I303_05281 I303_05281 I303_05046 I303_05046 NCS6 NCS6 I303_07570 I303_07570 I303_08446 I303_08446 I303_01155 I303_01155 I303_02213 I303_02213 I303_02085 I303_02085 NCS2 NCS2 I303_04098 I303_04098 I303_03398 I303_03398
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
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gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
URM1Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] (146 aa)
I303_05281Thiosulfate/3-mercaptopyruvate sulfurtransferase. (334 aa)
I303_05046Mitochondrial protein. (474 aa)
NCS6Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (361 aa)
I303_07570tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase. (472 aa)
I303_08446Uncharacterized protein. (293 aa)
I303_01155Endoplasmic reticulum protein. (186 aa)
I303_02213Cysteine desulfurase IscS. (500 aa)
I303_02085Adenylyltransferase and sulfurtransferase. (432 aa)
NCS2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (531 aa)
I303_04098Uncharacterized protein. (322 aa)
I303_03398Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (194 aa)
Your Current Organism:
Kwoniella dejecticola
NCBI taxonomy Id: 1296121
Other names: Cryptococcus dejecticola CBS 10117, K. dejecticola CBS 10117, Kwoniella dejecticola CBS 10117
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