STRINGSTRING
hrcA hrcA grpE grpE dnaK dnaK AKQ63371.1 AKQ63371.1 AKQ63372.1 AKQ63372.1 AKQ63380.1 AKQ63380.1 clpP clpP htpG htpG AKQ64195.1 AKQ64195.1 AKQ64266.1 AKQ64266.1 AKQ64267.1 AKQ64267.1 AKQ64268.1 AKQ64268.1 AKQ64269.1 AKQ64269.1 AKQ64270.1 AKQ64270.1 AKQ64271.1 AKQ64271.1 AKQ64305.1 AKQ64305.1 AKQ64560.1 AKQ64560.1 AKQ64677.1 AKQ64677.1 AKQ64678.1 AKQ64678.1 AKQ64679.1 AKQ64679.1 AKQ64803.1 AKQ64803.1 clpB clpB groL groL groS groS AKQ65145.1 AKQ65145.1 AKQ65152.1 AKQ65152.1 AKQ65153.1 AKQ65153.1 AKQ65154.1 AKQ65154.1 AKQ65264.1 AKQ65264.1 AKQ65265.1 AKQ65265.1 groL-2 groL-2 ftsH ftsH ftsH-2 ftsH-2 grpE-2 grpE-2 AKQ65707.1 AKQ65707.1 AKQ65814.1 AKQ65814.1 AKQ65815.1 AKQ65815.1 clpX clpX AKQ65946.1 AKQ65946.1 lon lon AKQ66243.1 AKQ66243.1 AKQ66244.1 AKQ66244.1 dnaJ dnaJ hflX hflX dnaK-2 dnaK-2 AKQ66920.1 AKQ66920.1 AKQ66921.1 AKQ66921.1 AKQ67080.1 AKQ67080.1 AKQ67081.1 AKQ67081.1 AKQ67082.1 AKQ67082.1 hslU hslU hslV hslV AKQ67163.1 AKQ67163.1 AKQ67185.1 AKQ67185.1 AKQ67186.1 AKQ67186.1 AKQ67368.1 AKQ67368.1 AKQ67369.1 AKQ67369.1 AKQ67371.1 AKQ67371.1 AKQ67887.1 AKQ67887.1 lon-2 lon-2 clpX-2 clpX-2 clpP-2 clpP-2 AKQ68679.1 AKQ68679.1 AKQ68680.1 AKQ68680.1 AKQ68681.1 AKQ68681.1 AKQ68964.1 AKQ68964.1 AKQ69223.1 AKQ69223.1 dnaJ-2 dnaJ-2 AKQ69342.1 AKQ69342.1 htpX htpX AKQ69575.1 AKQ69575.1 AKQ70603.1 AKQ70603.1 AKQ70604.1 AKQ70604.1 AKQ70606.1 AKQ70606.1 AKQ70720.1 AKQ70720.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (343 aa)
grpEHeat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] (284 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (606 aa)
AKQ63371.1Chaperone protein DnaK. (1174 aa)
AKQ63372.1Lysine-N-methylase. (426 aa)
AKQ63380.1TPR repeat, SEL1 subfamily. (266 aa)
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (203 aa)
htpGChaperone protein HtpG; Molecular chaperone. Has ATPase activity. (651 aa)
AKQ64195.1Chaperone protein DnaK. (520 aa)
AKQ64266.1Retron-type RNA-directed DNA polymerase. (449 aa)
AKQ64267.1Hypothetical protein. (192 aa)
AKQ64268.1Chaperone protein DnaK; Belongs to the heat shock protein 70 family. (572 aa)
AKQ64269.1ATP-dependent protease La. (506 aa)
AKQ64270.1Hypothetical protein. (768 aa)
AKQ64271.1Hypothetical protein. (597 aa)
AKQ64305.1Cell division protein FtsH. (585 aa)
AKQ64560.1Cell division protein FtsH; Belongs to the AAA ATPase family. (812 aa)
AKQ64677.1DnaK-related protein. (925 aa)
AKQ64678.1Sulfate permease; Belongs to the heat shock protein 70 family. (620 aa)
AKQ64679.1Hypothetical protein. (208 aa)
AKQ64803.1Chaperone protein DnaK; Belongs to the heat shock protein 70 family. (505 aa)
clpBClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (874 aa)
groLHeat shock protein 60 family chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (549 aa)
groSHeat shock protein 60 family co-chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa)
AKQ65145.1ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. (884 aa)
AKQ65152.1ClpB protein. (764 aa)
AKQ65153.1ATP-dependent Clp protease ATP-binding subunit ClpA. (1128 aa)
AKQ65154.1ATP-dependent Clp protease ATP-binding subunit ClpA. (1135 aa)
AKQ65264.1DNA-binding response regulator KdpE. (627 aa)
AKQ65265.1Lipid A export ATP-binding/permease protein MsbA. (594 aa)
groL-2Heat shock protein 60 family chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (547 aa)
ftsHCell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (638 aa)
ftsH-2Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (673 aa)
grpE-2Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] (214 aa)
AKQ65707.1Heat shock protein Hsp20; Belongs to the small heat shock protein (HSP20) family. (137 aa)
AKQ65814.1Ketopantoate reductase PanG. (267 aa)
AKQ65815.1ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. (843 aa)
clpXATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (425 aa)
AKQ65946.1Chaperone protein DnaK; Belongs to the heat shock protein 70 family. (506 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (810 aa)
AKQ66243.1Chaperone protein DnaK; Belongs to the heat shock protein 70 family. (772 aa)
AKQ66244.1Hypothetical protein. (37 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (389 aa)
hflXGTP-binding protein related to HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (475 aa)
dnaK-2Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (636 aa)
AKQ66920.1HflC protein; HflC and HflK could regulate a protease. (312 aa)
AKQ66921.1HflK protein; HflC and HflK could encode or regulate a protease. (348 aa)
AKQ67080.1TPR domain protein. (292 aa)
AKQ67081.1Chaperone protein DnaK; Belongs to the heat shock protein 70 family. (613 aa)
AKQ67082.1TolA protein. (456 aa)
hslUATP-dependent hsl protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (465 aa)
hslVATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (175 aa)
AKQ67163.1Putative membrane protein; Belongs to the BI1 family. (236 aa)
AKQ67185.1Sigma-70 region 4 domain protein. (163 aa)
AKQ67186.1Hypothetical protein. (174 aa)
AKQ67368.1Chaperone protein DnaK; Belongs to the heat shock protein 70 family. (551 aa)
AKQ67369.1Heat shock protein DnaJ domain protein. (301 aa)
AKQ67371.1ATP-dependent Clp protease ATP-binding subunit ClpX; Belongs to the ClpX chaperone family. (356 aa)
AKQ67887.1Putative ATP:guanido phosphotransferase YacI; Belongs to the ATP:guanido phosphotransferase family. (339 aa)
lon-2ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (816 aa)
clpX-2ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (427 aa)
clpP-2ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (206 aa)
AKQ68679.1Beta-lactamase-like precursor; Belongs to the UPF0173 family. (277 aa)
AKQ68680.1Chaperone protein HtpG. (620 aa)
AKQ68681.1Hypothetical protein. (375 aa)
AKQ68964.1Heat shock protein, Hsp20 family; Belongs to the small heat shock protein (HSP20) family. (147 aa)
AKQ69223.1Chaperone protein DnaK. (418 aa)
dnaJ-2Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (375 aa)
AKQ69342.1Lipid A export ATP-binding/permease protein MsbA. (587 aa)
htpXPutative protease htpX; Belongs to the peptidase M48B family. (305 aa)
AKQ69575.1ATP-dependent Clp protease ATP-binding subunit ClpX; Belongs to the ClpX chaperone family. (381 aa)
AKQ70603.1Hypothetical protein. (48 aa)
AKQ70604.1Chaperone protein DnaK; Belongs to the heat shock protein 70 family. (608 aa)
AKQ70606.1Hypothetical protein. (705 aa)
AKQ70720.1Hypothetical protein. (265 aa)
Your Current Organism:
Myxococcus hansupus
NCBI taxonomy Id: 1297742
Other names: M. hansupus, Myxococcus sp. (contaminant ex DSM 436), Myxococcus sp. mixupus
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