(32 nodes) Stress response, and Heat shock protein 70 family network (Myxococcus hansupus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Predicted Interactions

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Your Input:
	hrcA	Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (343 aa)
	grpE	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] (284 aa)
	dnaK	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (606 aa)
	htpG	Chaperone protein HtpG; Molecular chaperone. Has ATPase activity. (651 aa)
	AKQ64195.1	Chaperone protein DnaK. (520 aa)
	AKQ64803.1	Chaperone protein DnaK; Belongs to the heat shock protein 70 family. (505 aa)
	clpB	ClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (874 aa)
	groL	Heat shock protein 60 family chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (549 aa)
	groS	Heat shock protein 60 family co-chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa)
	AKQ65145.1	ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. (884 aa)
	AKQ65152.1	ClpB protein. (764 aa)
	AKQ65153.1	ATP-dependent Clp protease ATP-binding subunit ClpA. (1128 aa)
	AKQ65154.1	ATP-dependent Clp protease ATP-binding subunit ClpA. (1135 aa)
	AKQ65264.1	DNA-binding response regulator KdpE. (627 aa)
	groL-2	Heat shock protein 60 family chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (547 aa)
	grpE-2	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] (214 aa)
	AKQ65707.1	Heat shock protein Hsp20; Belongs to the small heat shock protein (HSP20) family. (137 aa)
	AKQ65946.1	Chaperone protein DnaK; Belongs to the heat shock protein 70 family. (506 aa)
	lon	ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (810 aa)
	dnaJ	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (389 aa)
	dnaK-2	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (636 aa)
	AKQ67080.1	TPR domain protein. (292 aa)
	AKQ67081.1	Chaperone protein DnaK; Belongs to the heat shock protein 70 family. (613 aa)
	AKQ67082.1	TolA protein. (456 aa)
	hslU	ATP-dependent hsl protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (465 aa)
	hslV	ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (175 aa)
	AKQ67368.1	Chaperone protein DnaK; Belongs to the heat shock protein 70 family. (551 aa)
	AKQ67369.1	Heat shock protein DnaJ domain protein. (301 aa)
	AKQ67887.1	Putative ATP:guanido phosphotransferase YacI; Belongs to the ATP:guanido phosphotransferase family. (339 aa)
	AKQ68964.1	Heat shock protein, Hsp20 family; Belongs to the small heat shock protein (HSP20) family. (147 aa)
	AKQ69223.1	Chaperone protein DnaK. (418 aa)
	dnaJ-2	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (375 aa)

Your Current Organism:

Myxococcus hansupus

NCBI taxonomy Id: 1297742
Other names: M. hansupus, Myxococcus sp. (contaminant ex DSM 436), Myxococcus sp. mixupus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKQ64195.1	AKQ65145.1	A176_001107	A176_002057	Chaperone protein DnaK.	ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family.	0.565
AKQ64195.1	AKQ65152.1	A176_001107	A176_002064	Chaperone protein DnaK.	ClpB protein.	0.565
AKQ64195.1	AKQ65153.1	A176_001107	A176_002065	Chaperone protein DnaK.	ATP-dependent Clp protease ATP-binding subunit ClpA.	0.565
AKQ64195.1	AKQ65154.1	A176_001107	A176_002066	Chaperone protein DnaK.	ATP-dependent Clp protease ATP-binding subunit ClpA.	0.565
AKQ64195.1	AKQ65264.1	A176_001107	A176_002176	Chaperone protein DnaK.	DNA-binding response regulator KdpE.	0.643
AKQ64195.1	AKQ65707.1	A176_001107	A176_002619	Chaperone protein DnaK.	Heat shock protein Hsp20; Belongs to the small heat shock protein (HSP20) family.	0.430
AKQ64195.1	AKQ67082.1	A176_001107	A176_003994	Chaperone protein DnaK.	TolA protein.	0.624
AKQ64195.1	AKQ67369.1	A176_001107	A176_004281	Chaperone protein DnaK.	Heat shock protein DnaJ domain protein.	0.712
AKQ64195.1	AKQ68964.1	A176_001107	A176_005876	Chaperone protein DnaK.	Heat shock protein, Hsp20 family; Belongs to the small heat shock protein (HSP20) family.	0.430
AKQ64195.1	clpB	A176_001107	A176_001794	Chaperone protein DnaK.	ClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.565
AKQ64195.1	dnaJ	A176_001107	A176_003656	Chaperone protein DnaK.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.909
AKQ64195.1	dnaJ-2	A176_001107	A176_006252	Chaperone protein DnaK.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.903
AKQ64195.1	groL	A176_001107	A176_001982	Chaperone protein DnaK.	Heat shock protein 60 family chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.684
AKQ64195.1	groL-2	A176_001107	A176_002429	Chaperone protein DnaK.	Heat shock protein 60 family chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.685
AKQ64195.1	groS	A176_001107	A176_001983	Chaperone protein DnaK.	Heat shock protein 60 family co-chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.664
AKQ64195.1	grpE	A176_001107	A176_000215	Chaperone protein DnaK.	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]	0.896
AKQ64195.1	grpE-2	A176_001107	A176_002571	Chaperone protein DnaK.	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]	0.731
AKQ64195.1	hrcA	A176_001107	A176_000125	Chaperone protein DnaK.	Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.583
AKQ64195.1	hslU	A176_001107	A176_003996	Chaperone protein DnaK.	ATP-dependent hsl protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	0.474
AKQ64195.1	hslV	A176_001107	A176_003997	Chaperone protein DnaK.	ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	0.415