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hemC hemC hemN hemN cbiK cbiK cobA cobA cobN cobN TST_0288 TST_0288 cobB cobB hemL hemL cobL cobL cobM cobM cobJ cobJ TST_0729 TST_0729 hemB hemB hemD hemD purC purC hemY hemY hemH hemH cobP cobP cbiB cbiB cobT cobT TST_0971 TST_0971 TST_1021 TST_1021 TST_1142 TST_1142 TST_1143 TST_1143 hemE hemE cbiD cbiD mET8 mET8 cobI- cobI- cobQ cobQ cobS cobS hemA hemA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (300 aa)
hemNOxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (377 aa)
cbiKSirohydrochlorin cobaltochelatase. (326 aa)
cobAuroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (241 aa)
cobNCobaltochelatase CobN. (1250 aa)
TST_0288cob(I)alamin adenosyltransferase. (177 aa)
cobBCobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (450 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase. (427 aa)
cobLprecorrin-6Y C5,15-methyltransferase/precorrin-8W decarboxylase. (381 aa)
cobMPrecorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. (525 aa)
cobJprecorrin-3B C17-methyltransferase. (455 aa)
TST_0729Conserved hypothetical protein. (74 aa)
hemBPorphobilinogen synthase; Belongs to the ALAD family. (325 aa)
hemDuroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (255 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (292 aa)
hemYOxygen-dependent protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (456 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (322 aa)
cobPAdenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase. (167 aa)
cbiBAdenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (305 aa)
cobTNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (356 aa)
TST_0971Glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (435 aa)
TST_1021cob(I)alamin adenosyltransferase. (178 aa)
TST_1142Cobalt/nickel transport system permease. (98 aa)
TST_1143Cobalt/nickel transport system permease. (210 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (343 aa)
cbiDcobalt-precorrin-5B (C1)-methyltransferase; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (332 aa)
mET8Precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase. (151 aa)
cobI-Precorrin-2/cobalt-factor-2 C20-methyltransferase. (220 aa)
cobQAdenosylcobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (477 aa)
cobSadenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (235 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (425 aa)
Your Current Organism:
Thermosulfidibacter takaii
NCBI taxonomy Id: 1298851
Other names: T. takaii ABI70S6, Thermosulfidibacter takaii ABI70S6
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