(16 nodes) Mismatch repair network (Thermosulfidibacter takaii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	dnaN	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (384 aa)
	holA	DNA polymerase III subunit delta. (323 aa)
	dnaX	DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (499 aa)
	TST_0426	Hypothetical protein; Similar to N-terminus of DNA polymerase III subunit delta' HolB EC:2.7.7.7. (294 aa)
	xseA	Exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (448 aa)
	TST_0813	DNA helicase II/ATP-dependent DNA helicase PcrA. (870 aa)
	TST_0815	Fused protein of serine/threonine protein kinase, bacterial and DNA polymerase III subunit epsilon. (279 aa)
	recJ	single-stranded-DNA-specific exonuclease. (556 aa)
	ligA	DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (672 aa)
	mutS2	DNA mismatch repair protein MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (763 aa)
	TST_0965	DNA helicase II/ATP-dependent DNA helicase PcrA. (721 aa)
	mutS	DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (825 aa)
	mutL	DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (527 aa)
	ssb	Single-strand DNA-binding protein. (139 aa)
	dnaE	DNA polymerase III subunit alpha. (1151 aa)
	xseB	Exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (72 aa)

Your Current Organism:

Thermosulfidibacter takaii

NCBI taxonomy Id: 1298851
Other names: T. takaii ABI70S6, Thermosulfidibacter takaii ABI70S6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TST_0426	TST_0815	TST_0426	TST_0815	Hypothetical protein; Similar to N-terminus of DNA polymerase III subunit delta' HolB EC:2.7.7.7.	Fused protein of serine/threonine protein kinase, bacterial and DNA polymerase III subunit epsilon.	0.938
TST_0426	dnaE	TST_0426	TST_1702	Hypothetical protein; Similar to N-terminus of DNA polymerase III subunit delta' HolB EC:2.7.7.7.	DNA polymerase III subunit alpha.	0.991
TST_0426	dnaN	TST_0426	TST_0002	Hypothetical protein; Similar to N-terminus of DNA polymerase III subunit delta' HolB EC:2.7.7.7.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.992
TST_0426	dnaX	TST_0426	TST_0380	Hypothetical protein; Similar to N-terminus of DNA polymerase III subunit delta' HolB EC:2.7.7.7.	DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.923
TST_0426	holA	TST_0426	TST_0112	Hypothetical protein; Similar to N-terminus of DNA polymerase III subunit delta' HolB EC:2.7.7.7.	DNA polymerase III subunit delta.	0.991
TST_0426	ssb	TST_0426	TST_1667	Hypothetical protein; Similar to N-terminus of DNA polymerase III subunit delta' HolB EC:2.7.7.7.	Single-strand DNA-binding protein.	0.913
TST_0813	TST_0815	TST_0813	TST_0815	DNA helicase II/ATP-dependent DNA helicase PcrA.	Fused protein of serine/threonine protein kinase, bacterial and DNA polymerase III subunit epsilon.	0.902
TST_0813	TST_0965	TST_0813	TST_0965	DNA helicase II/ATP-dependent DNA helicase PcrA.	DNA helicase II/ATP-dependent DNA helicase PcrA.	0.930
TST_0813	dnaE	TST_0813	TST_1702	DNA helicase II/ATP-dependent DNA helicase PcrA.	DNA polymerase III subunit alpha.	0.636
TST_0813	dnaN	TST_0813	TST_0002	DNA helicase II/ATP-dependent DNA helicase PcrA.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.922
TST_0813	ligA	TST_0813	TST_0857	DNA helicase II/ATP-dependent DNA helicase PcrA.	DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.	0.895
TST_0813	mutL	TST_0813	TST_1650	DNA helicase II/ATP-dependent DNA helicase PcrA.	DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	0.885
TST_0813	mutS	TST_0813	TST_1369	DNA helicase II/ATP-dependent DNA helicase PcrA.	DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.	0.430
TST_0815	TST_0426	TST_0815	TST_0426	Fused protein of serine/threonine protein kinase, bacterial and DNA polymerase III subunit epsilon.	Hypothetical protein; Similar to N-terminus of DNA polymerase III subunit delta' HolB EC:2.7.7.7.	0.938
TST_0815	TST_0813	TST_0815	TST_0813	Fused protein of serine/threonine protein kinase, bacterial and DNA polymerase III subunit epsilon.	DNA helicase II/ATP-dependent DNA helicase PcrA.	0.902
TST_0815	TST_0965	TST_0815	TST_0965	Fused protein of serine/threonine protein kinase, bacterial and DNA polymerase III subunit epsilon.	DNA helicase II/ATP-dependent DNA helicase PcrA.	0.516
TST_0815	dnaE	TST_0815	TST_1702	Fused protein of serine/threonine protein kinase, bacterial and DNA polymerase III subunit epsilon.	DNA polymerase III subunit alpha.	0.994
TST_0815	dnaN	TST_0815	TST_0002	Fused protein of serine/threonine protein kinase, bacterial and DNA polymerase III subunit epsilon.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.940
TST_0815	dnaX	TST_0815	TST_0380	Fused protein of serine/threonine protein kinase, bacterial and DNA polymerase III subunit epsilon.	DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.938
TST_0815	holA	TST_0815	TST_0112	Fused protein of serine/threonine protein kinase, bacterial and DNA polymerase III subunit epsilon.	DNA polymerase III subunit delta.	0.942