(31 nodes) Citrate cycle (TCA cycle), and Malate dehydrogenase activity network (Wallemia ichthyophaga)

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	J056_002743	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (365 aa)
	J056_002821	Malate dehydrogenase. (341 aa)
	J056_002571	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (367 aa)
	J056_002608	Uncharacterized protein. (989 aa)
	J056_002393	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (459 aa)
	J056_001922	Transket_pyr domain-containing protein. (1290 aa)
	J056_001853	Dihydrolipoyl dehydrogenase. (539 aa)
	J056_001737	Malic enzyme. (544 aa)
	J056_001666	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit. (163 aa)
	J056_001642	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (413 aa)
	J056_001217	Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (367 aa)
	J056_001291	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (267 aa)
	J056_004756	Formyltetrahydrofolate deformylase. (348 aa)
	J056_004699	Malate dehydrogenase. (333 aa)
	J056_004822	Uncharacterized protein. (182 aa)
	J056_002627	Citrate synthase; Belongs to the citrate synthase family. (458 aa)
	J056_003829	Uncharacterized protein. (589 aa)
	J056_004361	Putative NAD-dependent malic enzyme 3. (607 aa)
	J056_003959	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (426 aa)
	J056_003336	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (778 aa)
	J056_003402	UPF0012 hydrolase C26A3.11. (1390 aa)
	J056_003016	Uncharacterized protein. (308 aa)
	J056_004217	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (327 aa)
	J056_004017	Transket_pyr domain-containing protein. (1019 aa)
	J056_003637	Lipoyl-binding domain-containing protein. (399 aa)
	J056_002003	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1144 aa)
	J056_002098	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (641 aa)
	J056_002313	Phosphoenolpyruvate carboxykinase. (544 aa)
	J056_000070	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1192 aa)
	J056_003128	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (368 aa)
	J056_000128	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (420 aa)

Your Current Organism:

Wallemia ichthyophaga

NCBI taxonomy Id: 1299270
Other names: W. ichthyophaga EXF-994, Wallemia ichthyophaga EXF-994

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
J056_000070	J056_000128	R9ARB8	R9AXI4	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.692
J056_000070	J056_001217	R9ARB8	R9ACW6	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	0.815
J056_000070	J056_001291	R9ARB8	R9AD16	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.576
J056_000070	J056_001642	R9ARB8	R9ABQ1	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.952
J056_000070	J056_001737	R9ARB8	R9ABH5	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Malic enzyme.	0.975
J056_000070	J056_001853	R9ARB8	R9AB14	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Dihydrolipoyl dehydrogenase.	0.418
J056_000070	J056_002003	R9ARB8	R9APG1	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	0.947
J056_000070	J056_002313	R9ARB8	R9AQA6	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Phosphoenolpyruvate carboxykinase.	0.957
J056_000070	J056_002393	R9ARB8	R9AAP2	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.864
J056_000070	J056_002571	R9ARB8	R9AA48	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.958
J056_000070	J056_002608	R9ARB8	R9AA50	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Uncharacterized protein.	0.648
J056_000070	J056_002627	R9ARB8	R9AFY5	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Citrate synthase; Belongs to the citrate synthase family.	0.973
J056_000070	J056_002821	R9ARB8	R9A9T6	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Malate dehydrogenase.	0.963
J056_000070	J056_003336	R9ARB8	R9AKP8	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.626
J056_000070	J056_003402	R9ARB8	R9AL90	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	UPF0012 hydrolase C26A3.11.	0.836
J056_000070	J056_003829	R9ARB8	R9AHC4	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Uncharacterized protein.	0.611
J056_000070	J056_004217	R9ARB8	R9AMV7	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.606
J056_000070	J056_004361	R9ARB8	R9AHG6	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Putative NAD-dependent malic enzyme 3.	0.975
J056_000070	J056_004699	R9ARB8	R9AFD4	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Malate dehydrogenase.	0.963
J056_000070	J056_004756	R9ARB8	R9AFD3	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Formyltetrahydrofolate deformylase.	0.801