(24 nodes) RNA phosphodiester bond hydrolysis, exonucleolytic network (Wallemia ichthyophaga)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	J056_003537	Exonuclease domain-containing protein. (635 aa)
	J056_004750	Werner Syndrome-like exonuclease. (378 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1185 aa)
	J056_002516	Exosome complex component RRP43. (280 aa)
	J056_001881	UPF0406 protein CG. (257 aa)
	J056_003868	Exosome complex component MTR3. (258 aa)
	J056_001665	Exosome complex exonuclease rrp6. (794 aa)
	J056_003640	Glucose-repressible alcohol dehydrogenase transcriptional effector. (612 aa)
	J056_001332	Exosome complex component csl4. (188 aa)
	J056_003728	Exosome complex component rrp40. (239 aa)
	J056_003791	ATP-dependent RNA helicase mtr4. (1087 aa)
	J056_001127	Exosome complex component rrp45. (295 aa)
	J056_003029	RNA exonuclease NGL2. (1332 aa)
	J056_001967	CCR4-NOT transcription complex subunit 7. (306 aa)
	J056_002308	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1491 aa)
	J056_000194	Exosome complex component rrp4. (327 aa)
	J056_000401	Putative oligoribonuclease. (132 aa)
	J056_002813	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (982 aa)
	J056_003176	Ribosome biosis protein brx1. (303 aa)
	J056_002656	RNB domain-containing protein. (927 aa)
	J056_001627	Helicase C-terminal domain-containing protein. (679 aa)
	J056_001629	RNase_PH domain-containing protein. (316 aa)
	J056_001228	Exosome complex exonuclease dis3; Belongs to the RNR ribonuclease family. (980 aa)
	J056_000942	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (1259 aa)

Your Current Organism:

Wallemia ichthyophaga

NCBI taxonomy Id: 1299270
Other names: W. ichthyophaga EXF-994, Wallemia ichthyophaga EXF-994

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
J056_000194	J056_000942	R9AXN0	R9ADX2	Exosome complex component rrp4.	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.	0.957
J056_000194	J056_001127	R9AXN0	R9AJL4	Exosome complex component rrp4.	Exosome complex component rrp45.	0.999
J056_000194	J056_001228	R9AXN0	R9ACR6	Exosome complex component rrp4.	Exosome complex exonuclease dis3; Belongs to the RNR ribonuclease family.	0.998
J056_000194	J056_001332	R9AXN0	R9AIE2	Exosome complex component rrp4.	Exosome complex component csl4.	0.999
J056_000194	J056_001629	R9AXN0	R9ABU0	Exosome complex component rrp4.	RNase_PH domain-containing protein.	0.999
J056_000194	J056_001665	R9AXN0	R9AHP4	Exosome complex component rrp4.	Exosome complex exonuclease rrp6.	0.431
J056_000194	J056_002308	R9AXN0	R9AQA1	Exosome complex component rrp4.	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	0.675
J056_000194	J056_002516	R9AXN0	R9AGK0	Exosome complex component rrp4.	Exosome complex component RRP43.	0.999
J056_000194	J056_002656	R9AXN0	R9AAB9	Exosome complex component rrp4.	RNB domain-containing protein.	0.891
J056_000194	J056_003176	R9AXN0	R9A9J7	Exosome complex component rrp4.	Ribosome biosis protein brx1.	0.416
J056_000194	J056_003728	R9AXN0	R9AIL2	Exosome complex component rrp4.	Exosome complex component rrp40.	0.999
J056_000194	J056_003791	R9AXN0	R9AJ23	Exosome complex component rrp4.	ATP-dependent RNA helicase mtr4.	0.994
J056_000194	J056_003868	R9AXN0	R9AHH2	Exosome complex component rrp4.	Exosome complex component MTR3.	0.999
J056_000401	J056_003537	R9AR36	R9AEY8	Putative oligoribonuclease.	Exonuclease domain-containing protein.	0.955
J056_000942	J056_000194	R9ADX2	R9AXN0	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.	Exosome complex component rrp4.	0.957
J056_000942	J056_001127	R9ADX2	R9AJL4	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.	Exosome complex component rrp45.	0.960
J056_000942	J056_001332	R9ADX2	R9AIE2	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.	Exosome complex component csl4.	0.962
J056_000942	J056_001627	R9ADX2	R9ABN7	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.	Helicase C-terminal domain-containing protein.	0.661
J056_000942	J056_001629	R9ADX2	R9ABU0	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.	RNase_PH domain-containing protein.	0.921
J056_000942	J056_001665	R9ADX2	R9AHP4	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.	Exosome complex exonuclease rrp6.	0.556