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NCS2 NCS2 J056_002626 J056_002626 J056_002372 J056_002372 J056_001786 J056_001786 J056_001923 J056_001923 J056_001661 J056_001661 J056_001188 J056_001188 J056_000842 J056_000842 J056_000818 J056_000818 J056_000975 J056_000975 J056_000483 J056_000483 J056_000517 J056_000517 J056_000573 J056_000573 J056_000600 J056_000600 J056_004757 J056_004757 J056_004435 J056_004435 J056_004534 J056_004534 J056_002491 J056_002491 J056_004194 J056_004194 J056_003884 J056_003884 J056_003910 J056_003910 J056_003901 J056_003901 J056_003599 J056_003599 J056_003809 J056_003809 J056_001152 J056_001152 J056_000839 J056_000839 J056_000914 J056_000914 NCS6 NCS6 J056_004678 J056_004678 J056_003522 J056_003522 J056_004252 J056_004252 J056_003912 J056_003912 J056_001982 J056_001982 J056_000108 J056_000108 J056_000284 J056_000284 J056_000105 J056_000105 J056_000341 J056_000341 J056_000282 J056_000282 J056_002920 J056_002920 MET3 MET3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCS2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (447 aa)
J056_002626Putative glutamine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (850 aa)
J056_002372Tyrosine--tRNA ligase. (422 aa)
J056_001786Usp domain-containing protein. (445 aa)
J056_001923Electron transfer flavoprotein subunit beta. (267 aa)
J056_001661Isoleucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (970 aa)
J056_001188Protein transport protein SEC13; Belongs to the WD repeat SEC13 family. (677 aa)
J056_000842Putative glutamate--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (810 aa)
J056_000818Putative leucine--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (1092 aa)
J056_000975Tyrosine--tRNA ligase. (430 aa)
J056_000483Usp domain-containing protein. (215 aa)
J056_000517tRNA-synt_1g domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (541 aa)
J056_000573Pantoate--beta-alanine ligase. (272 aa)
J056_000600Nicotinamide-nucleotide adenylyltransferase; Belongs to the eukaryotic NMN adenylyltransferase family. (442 aa)
J056_004757Putative asparagine synthetase. (589 aa)
J056_004435Putative methionine--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (690 aa)
J056_004534Argininosuccinate synthase. (424 aa)
J056_002491Phosphoadenosine phosphosulfate reductase. (273 aa)
J056_004194Putative cysteine--tRNA ligase. (765 aa)
J056_003884Usp domain-containing protein. (198 aa)
J056_003910Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (345 aa)
J056_003901Usp domain-containing protein. (189 aa)
J056_003599Meiotically up-regulated 71 protein. (621 aa)
J056_003809Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1648 aa)
J056_001152Isoleucine--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (1082 aa)
J056_000839Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (708 aa)
J056_000914Tryptophan--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (488 aa)
NCS6Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (358 aa)
J056_004678Cryptochrome-1. (554 aa)
J056_003522tRNA-specific 2-thiouridylase MnmA. (380 aa)
J056_004252Valine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1103 aa)
J056_003912GMP synthase. (541 aa)
J056_001982ETF domain-containing protein. (340 aa)
J056_000108Asparagine synthetase domain-containing protein 1. (353 aa)
J056_000284Uncharacterized protein. (314 aa)
J056_000105Glutamate--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (465 aa)
J056_000341Deoxyribodipyrimidine photo-lyase. (609 aa)
J056_000282Putative choline-phosphate cytidylyltransferase. (289 aa)
J056_002920Universal stress protein A family protein C25B2.10. (254 aa)
MET3Sulfate adenylyltransferase; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. In the N-terminal section; belongs to the sulfate adenylyltransferase family. (576 aa)
Your Current Organism:
Wallemia ichthyophaga
NCBI taxonomy Id: 1299270
Other names: W. ichthyophaga EXF-994, Wallemia ichthyophaga EXF-994
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