STRINGSTRING
SEP55886.1 SEP55886.1 SEP58167.1 SEP58167.1 SEP60521.1 SEP60521.1 dnaX dnaX SEP60836.1 SEP60836.1 SEP61549.1 SEP61549.1 SEP62816.1 SEP62816.1 SEP62841.1 SEP62841.1 SEP64751.1 SEP64751.1 SEP75225.1 SEP75225.1 mutS mutS dnaG dnaG topA topA rnhB rnhB mutL mutL SEP83252.1 SEP83252.1 SEP83866.1 SEP83866.1 SEP92263.1 SEP92263.1 SEP92307.1 SEP92307.1 SEP88941.1 SEP88941.1 dinB dinB recA recA SEQ00159.1 SEQ00159.1 SEQ04345.1 SEQ04345.1 priA priA SEQ08788.1 SEQ08788.1 polA polA SEQ16246.1 SEQ16246.1 SEQ20179.1 SEQ20179.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEP55886.1Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (519 aa)
SEP58167.1DNA helicase-2 / ATP-dependent DNA helicase PcrA. (777 aa)
SEP60521.1Hypothetical protein. (81 aa)
dnaXDNA polymerase-3 subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (361 aa)
SEP60836.1DNA polymerase-3 subunit epsilon. (453 aa)
SEP61549.1DNA mismatch repair protein MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity. Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (731 aa)
SEP62816.1CBS domain-containing protein. (637 aa)
SEP62841.1DNA polymerase-3 subunit epsilon. (195 aa)
SEP64751.1ATP-dependent DNA helicase RecQ. (627 aa)
SEP75225.1DNA polymerase III, alpha subunit. (1508 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (874 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (675 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (828 aa)
rnhBRNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (231 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (620 aa)
SEP83252.1ATP-dependent DNA helicase RecQ. (745 aa)
SEP83866.1DNA polymerase-3 subunit epsilon. (270 aa)
SEP92263.1Helix-turn-helix domain-containing protein. (760 aa)
SEP92307.1DNA polymerase-3 subunit delta'. (410 aa)
SEP88941.1Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (159 aa)
dinBDNA polymerase-4; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (359 aa)
recARecombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (334 aa)
SEQ00159.1Single-strand binding protein. (137 aa)
SEQ04345.1DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] (372 aa)
priAReplication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (813 aa)
SEQ08788.1DNA polymerase III, delta subunit. (333 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (944 aa)
SEQ16246.1Hypothetical protein. (237 aa)
SEQ20179.1Single-strand binding protein. (106 aa)
Your Current Organism:
Flavobacterium urocaniciphilum
NCBI taxonomy Id: 1299341
Other names: DSM 27078, F. urocaniciphilum, Flavobacterium sp. YIT 12746, Flavobacterium urocaniciphilum Fujii et al. 2014, JCM 19142, YIT 12746
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