STRINGSTRING
AIJ04853.1 AIJ04853.1 AIJ04854.1 AIJ04854.1 cdhA cdhA cdhC-2 cdhC-2 AIJ04958.1 AIJ04958.1 mer mer AIJ05006.1 AIJ05006.1 AIJ05007.1 AIJ05007.1 AIJ05008.1 AIJ05008.1 AIJ05009.1 AIJ05009.1 AIJ05010.1 AIJ05010.1 AIJ05011.1 AIJ05011.1 AIJ05017.1 AIJ05017.1 AIJ05023.1 AIJ05023.1 AIJ05097.1 AIJ05097.1 AIJ05098.1 AIJ05098.1 AIJ05100.1 AIJ05100.1 AIJ05101.1 AIJ05101.1 AIJ05102.1 AIJ05102.1 AIJ05103.1 AIJ05103.1 AIJ05104.1 AIJ05104.1 AIJ05131.1 AIJ05131.1 AIJ05132.1 AIJ05132.1 AIJ05312.1 AIJ05312.1 AIJ05329.1 AIJ05329.1 AIJ05330.1 AIJ05330.1 AIJ05331.1 AIJ05331.1 AIJ05332.1 AIJ05332.1 AIJ05333.1 AIJ05333.1 AIJ05342.1 AIJ05342.1 AIJ05343.1 AIJ05343.1 AIJ05344.1 AIJ05344.1 AIJ05353.1 AIJ05353.1 AIJ05354.1 AIJ05354.1 AIJ05355.1 AIJ05355.1 AIJ05367.1 AIJ05367.1 AIJ05377.1 AIJ05377.1 mch mch AIJ05394.1 AIJ05394.1 AIJ05395.1 AIJ05395.1 endA endA AIJ05398.1 AIJ05398.1 AIJ05399.1 AIJ05399.1 AIJ05402.1 AIJ05402.1 AIJ05452.1 AIJ05452.1 AIJ05453.1 AIJ05453.1 AIJ05455.1 AIJ05455.1 AIJ05497.1 AIJ05497.1 AIJ05498.1 AIJ05498.1 AIJ05499.1 AIJ05499.1 AIJ05500.1 AIJ05500.1 AIJ05501.1 AIJ05501.1 AIJ05502.1 AIJ05502.1 AIJ05503.1 AIJ05503.1 AIJ05504.1 AIJ05504.1 AIJ05520.1 AIJ05520.1 AIJ05522.1 AIJ05522.1 AIJ05523.1 AIJ05523.1 AIJ05524.1 AIJ05524.1 AIJ05525.1 AIJ05525.1 AIJ05526.1 AIJ05526.1 AIJ05596.1 AIJ05596.1 AIJ05600.1 AIJ05600.1 cdhD cdhD cdhE cdhE AIJ05616.1 AIJ05616.1 mfnB mfnB AIJ05690.1 AIJ05690.1 AIJ05691.1 AIJ05691.1 ftsZ ftsZ ftr ftr mtd mtd AIJ05879.1 AIJ05879.1 AIJ05880.1 AIJ05880.1 mtrH mtrH mtrG mtrG mtrA mtrA mtrB mtrB mtrC mtrC mtrB-2 mtrB-2 mtrC-2 mtrC-2 mtrD mtrD mtrE mtrE AIJ05899.1 AIJ05899.1 AIJ05900.1 AIJ05900.1 AIJ05901.1 AIJ05901.1 AIJ05902.1 AIJ05902.1 AIJ05903.1 AIJ05903.1 AIJ05904.1 AIJ05904.1 AIJ05905.1 AIJ05905.1 AIJ05923.1 AIJ05923.1 AIJ05924.1 AIJ05924.1 AIJ05930.1 AIJ05930.1 AIJ05942.1 AIJ05942.1 AIJ05943.1 AIJ05943.1 hmd hmd AIJ05960.1 AIJ05960.1 AIJ05962.1 AIJ05962.1 mptA mptA AIJ05964.1 AIJ05964.1 AIJ05994.1 AIJ05994.1 AIJ05995.1 AIJ05995.1 AIJ05996.1 AIJ05996.1 AIJ05997.1 AIJ05997.1 AIJ06038.1 AIJ06038.1 AIJ06039.1 AIJ06039.1 AIJ06056.1 AIJ06056.1 AIJ06057.1 AIJ06057.1 AIJ06082.1 AIJ06082.1 AIJ06161.1 AIJ06161.1 AIJ06162.1 AIJ06162.1 AIJ06214.1 AIJ06214.1 hjc hjc AIJ06256.1 AIJ06256.1 AIJ06259.1 AIJ06259.1 AIJ06260.1 AIJ06260.1 AIJ06261.1 AIJ06261.1 AIJ06262.1 AIJ06262.1 AIJ06263.1 AIJ06263.1 AIJ06264.1 AIJ06264.1 AIJ06321.1 AIJ06321.1 AIJ06322.1 AIJ06322.1 AIJ06324.1 AIJ06324.1 AIJ06376.1 AIJ06376.1 AIJ06377.1 AIJ06377.1 AIJ06378.1 AIJ06378.1 AIJ06379.1 AIJ06379.1 AIJ06418.1 AIJ06418.1 AIJ06437.1 AIJ06437.1 AIJ06484.1 AIJ06484.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIJ04853.1CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (151 aa)
AIJ04854.1CO dehydrogenase/acetyl-CoA synthase epsilon subunit; COG1880. (146 aa)
cdhACO dehydrogenase/acetyl-CoA synthase alpha subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (773 aa)
cdhC-2CO dehydrogenase/acetyl-CoA synthase beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (738 aa)
AIJ04958.1Hypothetical protein; COG0433. (469 aa)
mer5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (331 aa)
AIJ05006.1Pyruvate ferredoxin oxidoreductase gamma subunit; COG1014. (131 aa)
AIJ05007.1Pyruvate ferredoxin oxidoreductase delta subunit; COG1144. (86 aa)
AIJ05008.1Pyruvate ferredoxin oxidoreductase alpha subunit; COG0674. (386 aa)
AIJ05009.1Pyruvate ferredoxin oxidoreductase beta subunit; COG1013. (295 aa)
AIJ05010.1Formate hydrogenlyase, subunit 2; COG1142. (164 aa)
AIJ05011.14Fe-4S ferredoxin iron-sulfur binding domain protein; COG1142. (141 aa)
AIJ05017.1Mur ligase middle domain protein; COG0770. (400 aa)
AIJ05023.1Coenzyme F420-reducing hydrogenase maturation factor subunit delta; COG0680. (157 aa)
AIJ05097.1Formate dehydrogenase subunit alpha; COG0243. (130 aa)
AIJ05098.1Formate dehydrogenase subunit alpha; COG0243. (497 aa)
AIJ05100.1Hypothetical protein; COG3436. (422 aa)
AIJ05101.1Hypothetical protein; COG1145. (362 aa)
AIJ05102.1Glutamate synthase (NADPH) GltB2 subunit; COG0069; Belongs to the glutamate synthase family. (454 aa)
AIJ05103.1Formylmethanofuran dehydrogenase subunit C; COG0070. (258 aa)
AIJ05104.1Coenzyme F420-reducing hydrogenase, beta subunit; COG1035. (355 aa)
AIJ05131.1Molybdopterin oxidoreductase; COG0243. (377 aa)
AIJ05132.1Coenzyme F420-reducing hydrogenase, beta subunit; COG1035. (379 aa)
AIJ05312.1Hypothetical protein; COG1630. (364 aa)
AIJ05329.1Hypothetical protein. (185 aa)
AIJ05330.1Hypothetical protein; COG4075. (112 aa)
AIJ05331.1Hypothetical protein; COG4075. (108 aa)
AIJ05332.1Hypothetical protein; COG1342; Belongs to the UPF0251 family. (124 aa)
AIJ05333.1Methyl coenzyme M reductase system, component A2; COG1123. (534 aa)
AIJ05342.1Hypothetical protein. (929 aa)
AIJ05343.1Methyl coenzyme M reductase II protein MtrC; COG4052. (273 aa)
AIJ05344.1Hypothetical protein. (142 aa)
AIJ05353.1Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (552 aa)
AIJ05354.1Methyl-coenzyme M reductase, gamma subunit; COG4057. (266 aa)
AIJ05355.1Methyl-coenzyme M reductase, beta subunit; COG4054. (447 aa)
AIJ05367.1Hypothetical protein; COG4069. (325 aa)
AIJ05377.1Methanogenesis marker protein 8; COG4022. (281 aa)
mchMethenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (323 aa)
AIJ05394.1Vanadium nitrogenase-associated protein N; COG2710. (351 aa)
AIJ05395.1Transposase, IS605 OrfB; COG0675. (493 aa)
endAtRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (174 aa)
AIJ05398.1Signal transduction protein with CBS domains; COG0517. (154 aa)
AIJ05399.1Beta-ribofuranosylaminobenzene 5'-phosphate synthase family; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). (318 aa)
AIJ05402.1Hypothetical protein; COG0433. (500 aa)
AIJ05452.1AIR synthase related protein domain protein; COG1973. (450 aa)
AIJ05453.1Hypothetical protein; COG1800. (306 aa)
AIJ05455.1Methanogenesis marker protein 3; COG4070; Belongs to the UPF0288 family. (498 aa)
AIJ05497.1Formylmethanofuran dehydrogenase subunit B; COG1029. (279 aa)
AIJ05498.1Tungsten-containing formylmethanofuran dehydrogenase subunit B; COG1029. (120 aa)
AIJ05499.14Fe-4S ferredoxin iron-sulfur binding domain protein; COG1145. (389 aa)
AIJ05500.1Coenzyme F420-reducing hydrogenase, alpha subunit; COG3259. (418 aa)
AIJ05501.1Coenzyme F420-reducing hydrogenase, gamma subunit; COG1941. (279 aa)
AIJ05502.1Coenzyme F420-reducing hydrogenase, delta subunit; COG1908. (46 aa)
AIJ05503.1CoB/CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (460 aa)
AIJ05504.1CoB/CoM heterodisulfide reductase subunit A; COG1148. (195 aa)
AIJ05520.1Formylmethanofuran dehydrogenase subunit C; COG2218. (273 aa)
AIJ05522.1Formylmethanofuran dehydrogenase subunit A; COG1229. (546 aa)
AIJ05523.1Formylmethanofuran dehydrogenase subunit D; COG1153. (133 aa)
AIJ05524.1Formylmethanofuran dehydrogenase subunit G; COG1145. (82 aa)
AIJ05525.14Fe-4S ferredoxin iron-sulfur binding domain protein; COG1145. (355 aa)
AIJ05526.14Fe-4S ferredoxin; COG1146. (148 aa)
AIJ05596.1Methyl-coenzyme M reductase operon protein D; COG4055. (160 aa)
AIJ05600.1Hypothetical protein; COG4008. (155 aa)
cdhDCO dehydrogenase/acetyl-CoA synthase delta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family. (396 aa)
cdhECO dehydrogenase/acetyl-CoA synthase gamma subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (490 aa)
AIJ05616.1Dihydropteroate synthase-related protein; COG0294. (527 aa)
mfnBHypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (235 aa)
AIJ05690.130S ribosomal protein S6 modification protein; COG0189. (291 aa)
AIJ05691.1Transcriptional regulator, XRE family; COG4800. (172 aa)
ftsZCell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (366 aa)
ftrFormylmethanofuran/tetrahydromethanopterin N-formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (301 aa)
mtdF420-dependent methylene tetrahydro methanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (235 aa)
AIJ05879.1CoB/CoM heterodisulfide reductase subunit C; COG1150. (186 aa)
AIJ05880.1CoB/CoM heterodisulfide reductase subunit B; COG2048. (295 aa)
mtrHTetrahydromethanopterin S-methyltransferase, subunit H; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. (319 aa)
mtrGTetrahydromethanopterin S-methyltransferase, subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (78 aa)
mtrATetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (253 aa)
mtrBTetrahydromethanopterin S-methyltransferase, subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (107 aa)
mtrCTetrahydromethanopterin S-methyltransferase, subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (183 aa)
mtrB-2Tetrahydromethanopterin S-methyltransferase, subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (109 aa)
mtrC-2Tetrahydromethanopterin S-methyltransferase, subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (265 aa)
mtrDTetrahydromethanopterin S-methyltransferase, subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (229 aa)
mtrETetrahydromethanopterin S-methyltransferase, subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (300 aa)
AIJ05899.1Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (553 aa)
AIJ05900.1Methyl-coenzyme M reductase, gamma subunit; COG4057. (260 aa)
AIJ05901.1Methyl-coenzyme M reductase operon protein C; COG4056. (158 aa)
AIJ05902.1Methyl-coenzyme M reductase operon protein D; COG4055. (163 aa)
AIJ05903.1Methyl-coenzyme M reductase, beta subunit; COG4054. (444 aa)
AIJ05904.1Hypothetical protein; COG1625. (415 aa)
AIJ05905.1H4MPT-linked C1 transfer pathway protein; COG1548. (327 aa)
AIJ05923.1CODH nickel-insertion accessory protein; COG3640. (238 aa)
AIJ05924.1ATPase; COG1672. (359 aa)
AIJ05930.1Hypothetical protein; COG1821. (268 aa)
AIJ05942.1Methanogenesis marker protein 17; COG4051. (188 aa)
AIJ05943.1Methanogenesis marker protein 17; COG1924. (412 aa)
hmdH(2)-dependent methylene tetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (321 aa)
AIJ05960.1Hypothetical protein; COG1418. (169 aa)
AIJ05962.1Hypothetical protein; COG2232. (390 aa)
mptAGTP cyclohydrolase; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (315 aa)
AIJ05964.1Hypothetical protein. (409 aa)
AIJ05994.1Coenzyme F420-reducing hydrogenase, beta subunit; COG1035. (261 aa)
AIJ05995.1Coenzyme F420-reducing hydrogenase, gamma subunit; COG1941. (214 aa)
AIJ05996.1Coenzyme F420-reducing hydrogenase, alpha subunit; COG3259. (298 aa)
AIJ05997.1CO dehydrogenase, catalytic subunit; COG1151. (624 aa)
AIJ06038.1Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG1411; Belongs to the HisA/HisF family. (226 aa)
AIJ06039.1Hypothetical protein. (162 aa)
AIJ06056.1Nitrogenase reductase NifH2; COG3640. (253 aa)
AIJ06057.1Aminotransferase class I and II; COG0436. (374 aa)
AIJ06082.1Glutamate synthase alpha subunit domain protein; COG2218. (318 aa)
AIJ06161.1Hypothetical protein; COG4050. (150 aa)
AIJ06162.1Hypothetical protein; COG4048. (128 aa)
AIJ06214.1Aspartate/glutamate/uridylate kinase 1; COG2054. (214 aa)
hjcResolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. (137 aa)
AIJ06256.1Hypothetical protein; COG4029. (155 aa)
AIJ06259.1Formylmethanofuran dehydrogenase subunit B; COG1029. (317 aa)
AIJ06260.1Formylmethanofuran dehydrogenase subunit B; COG1029. (120 aa)
AIJ06261.1Formylmethanofuran dehydrogenase subunit C; COG2218. (412 aa)
AIJ06262.1Formylmethanofuran dehydrogenase subunit A; COG1229. (561 aa)
AIJ06263.1Formylmethanofuran dehydrogenase subunit E; COG2191. (190 aa)
AIJ06264.14Fe-4S ferredoxin; COG1145. (49 aa)
AIJ06321.1ABC transporter; COG1123. (555 aa)
AIJ06322.1Hypothetical protein. (1091 aa)
AIJ06324.1Hypothetical protein. (227 aa)
AIJ06376.1Coenzyme F420-reducing hydrogenase, alpha subunit; COG3259. (385 aa)
AIJ06377.1Coenzyme F420-reducing hydrogenase maturation factor subunit delta, type 2; COG0680. (155 aa)
AIJ06378.1Coenzyme F420-reducing hydrogenase, gamma subunit; COG1941. (227 aa)
AIJ06379.1Coenzyme F420-reducing hydrogenase, beta subunit; COG1035. (282 aa)
AIJ06418.1triphosphoribosyl-dephospho-CoA protein; COG1767. (293 aa)
AIJ06437.1Archaeoflavoprotein; COG1036. (192 aa)
AIJ06484.1Hypothetical protein; COG1693. (539 aa)
Your Current Organism:
Methanocaldococcus bathoardescens
NCBI taxonomy Id: 1301915
Other names: DSM 27223, KACC 18232, M. bathoardescens, Methanocaldococcus bathoardescens Stewart et al. 2015, Methanocaldococcus sp. JH146, strain JH146
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