(104 nodes) Methane metabolism, and Oxidoreductase activity, acting on the aldehyde or oxo group of donors network (Methanocaldococcus bathoardescens)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	AIJ04853.1	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (151 aa)
	AIJ04854.1	CO dehydrogenase/acetyl-CoA synthase epsilon subunit; COG1880. (146 aa)
	cdhA	CO dehydrogenase/acetyl-CoA synthase alpha subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (773 aa)
	cdhC-2	CO dehydrogenase/acetyl-CoA synthase beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (738 aa)
	mer	5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (331 aa)
	AIJ05006.1	Pyruvate ferredoxin oxidoreductase gamma subunit; COG1014. (131 aa)
	AIJ05007.1	Pyruvate ferredoxin oxidoreductase delta subunit; COG1144. (86 aa)
	AIJ05008.1	Pyruvate ferredoxin oxidoreductase alpha subunit; COG0674. (386 aa)
	AIJ05009.1	Pyruvate ferredoxin oxidoreductase beta subunit; COG1013. (295 aa)
	AIJ05010.1	Formate hydrogenlyase, subunit 2; COG1142. (164 aa)
	AIJ05011.1	4Fe-4S ferredoxin iron-sulfur binding domain protein; COG1142. (141 aa)
	AIJ05017.1	Mur ligase middle domain protein; COG0770. (400 aa)
	AIJ05023.1	Coenzyme F420-reducing hydrogenase maturation factor subunit delta; COG0680. (157 aa)
	AIJ05097.1	Formate dehydrogenase subunit alpha; COG0243. (130 aa)
	AIJ05098.1	Formate dehydrogenase subunit alpha; COG0243. (497 aa)
	AIJ05100.1	Hypothetical protein; COG3436. (422 aa)
	AIJ05101.1	Hypothetical protein; COG1145. (362 aa)
	AIJ05102.1	Glutamate synthase (NADPH) GltB2 subunit; COG0069; Belongs to the glutamate synthase family. (454 aa)
	AIJ05103.1	Formylmethanofuran dehydrogenase subunit C; COG0070. (258 aa)
	AIJ05104.1	Coenzyme F420-reducing hydrogenase, beta subunit; COG1035. (355 aa)
	AIJ05131.1	Molybdopterin oxidoreductase; COG0243. (377 aa)
	AIJ05132.1	Coenzyme F420-reducing hydrogenase, beta subunit; COG1035. (379 aa)
	AIJ05329.1	Hypothetical protein. (185 aa)
	AIJ05330.1	Hypothetical protein; COG4075. (112 aa)
	AIJ05331.1	Hypothetical protein; COG4075. (108 aa)
	AIJ05332.1	Hypothetical protein; COG1342; Belongs to the UPF0251 family. (124 aa)
	AIJ05333.1	Methyl coenzyme M reductase system, component A2; COG1123. (534 aa)
	AIJ05342.1	Hypothetical protein. (929 aa)
	AIJ05343.1	Methyl coenzyme M reductase II protein MtrC; COG4052. (273 aa)
	AIJ05344.1	Hypothetical protein. (142 aa)
	AIJ05353.1	Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (552 aa)
	AIJ05354.1	Methyl-coenzyme M reductase, gamma subunit; COG4057. (266 aa)
	AIJ05355.1	Methyl-coenzyme M reductase, beta subunit; COG4054. (447 aa)
	AIJ05367.1	Hypothetical protein; COG4069. (325 aa)
	AIJ05377.1	Methanogenesis marker protein 8; COG4022. (281 aa)
	AIJ05394.1	Vanadium nitrogenase-associated protein N; COG2710. (351 aa)
	AIJ05455.1	Methanogenesis marker protein 3; COG4070; Belongs to the UPF0288 family. (498 aa)
	AIJ05497.1	Formylmethanofuran dehydrogenase subunit B; COG1029. (279 aa)
	AIJ05498.1	Tungsten-containing formylmethanofuran dehydrogenase subunit B; COG1029. (120 aa)
	AIJ05499.1	4Fe-4S ferredoxin iron-sulfur binding domain protein; COG1145. (389 aa)
	AIJ05500.1	Coenzyme F420-reducing hydrogenase, alpha subunit; COG3259. (418 aa)
	AIJ05501.1	Coenzyme F420-reducing hydrogenase, gamma subunit; COG1941. (279 aa)
	AIJ05502.1	Coenzyme F420-reducing hydrogenase, delta subunit; COG1908. (46 aa)
	AIJ05503.1	CoB/CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (460 aa)
	AIJ05504.1	CoB/CoM heterodisulfide reductase subunit A; COG1148. (195 aa)
	AIJ05520.1	Formylmethanofuran dehydrogenase subunit C; COG2218. (273 aa)
	AIJ05522.1	Formylmethanofuran dehydrogenase subunit A; COG1229. (546 aa)
	AIJ05523.1	Formylmethanofuran dehydrogenase subunit D; COG1153. (133 aa)
	AIJ05524.1	Formylmethanofuran dehydrogenase subunit G; COG1145. (82 aa)
	AIJ05525.1	4Fe-4S ferredoxin iron-sulfur binding domain protein; COG1145. (355 aa)
	AIJ05526.1	4Fe-4S ferredoxin; COG1146. (148 aa)
	AIJ05596.1	Methyl-coenzyme M reductase operon protein D; COG4055. (160 aa)
	AIJ05600.1	Hypothetical protein; COG4008. (155 aa)
	cdhD	CO dehydrogenase/acetyl-CoA synthase delta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family. (396 aa)
	cdhE	CO dehydrogenase/acetyl-CoA synthase gamma subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (490 aa)
	AIJ05691.1	Transcriptional regulator, XRE family; COG4800. (172 aa)
	ftsZ	Cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (366 aa)
	mtd	F420-dependent methylene tetrahydro methanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (235 aa)
	AIJ05879.1	CoB/CoM heterodisulfide reductase subunit C; COG1150. (186 aa)
	AIJ05880.1	CoB/CoM heterodisulfide reductase subunit B; COG2048. (295 aa)
	mtrH	Tetrahydromethanopterin S-methyltransferase, subunit H; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. (319 aa)
	mtrG	Tetrahydromethanopterin S-methyltransferase, subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (78 aa)
	mtrA	Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (253 aa)
	mtrB	Tetrahydromethanopterin S-methyltransferase, subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (107 aa)
	mtrC	Tetrahydromethanopterin S-methyltransferase, subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (183 aa)
	mtrB-2	Tetrahydromethanopterin S-methyltransferase, subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (109 aa)
	mtrC-2	Tetrahydromethanopterin S-methyltransferase, subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (265 aa)
	mtrD	Tetrahydromethanopterin S-methyltransferase, subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (229 aa)
	mtrE	Tetrahydromethanopterin S-methyltransferase, subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (300 aa)
	AIJ05899.1	Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (553 aa)
	AIJ05900.1	Methyl-coenzyme M reductase, gamma subunit; COG4057. (260 aa)
	AIJ05901.1	Methyl-coenzyme M reductase operon protein C; COG4056. (158 aa)
	AIJ05902.1	Methyl-coenzyme M reductase operon protein D; COG4055. (163 aa)
	AIJ05903.1	Methyl-coenzyme M reductase, beta subunit; COG4054. (444 aa)
	AIJ05904.1	Hypothetical protein; COG1625. (415 aa)
	AIJ05923.1	CODH nickel-insertion accessory protein; COG3640. (238 aa)
	AIJ05924.1	ATPase; COG1672. (359 aa)
	AIJ05942.1	Methanogenesis marker protein 17; COG4051. (188 aa)
	AIJ05943.1	Methanogenesis marker protein 17; COG1924. (412 aa)
	hmd	H(2)-dependent methylene tetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (321 aa)
	AIJ05994.1	Coenzyme F420-reducing hydrogenase, beta subunit; COG1035. (261 aa)
	AIJ05995.1	Coenzyme F420-reducing hydrogenase, gamma subunit; COG1941. (214 aa)
	AIJ05996.1	Coenzyme F420-reducing hydrogenase, alpha subunit; COG3259. (298 aa)
	AIJ05997.1	CO dehydrogenase, catalytic subunit; COG1151. (624 aa)
	AIJ06056.1	Nitrogenase reductase NifH2; COG3640. (253 aa)
	AIJ06082.1	Glutamate synthase alpha subunit domain protein; COG2218. (318 aa)
	AIJ06161.1	Hypothetical protein; COG4050. (150 aa)
	AIJ06162.1	Hypothetical protein; COG4048. (128 aa)
	hjc	Resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. (137 aa)
	AIJ06256.1	Hypothetical protein; COG4029. (155 aa)
	AIJ06259.1	Formylmethanofuran dehydrogenase subunit B; COG1029. (317 aa)
	AIJ06260.1	Formylmethanofuran dehydrogenase subunit B; COG1029. (120 aa)
	AIJ06261.1	Formylmethanofuran dehydrogenase subunit C; COG2218. (412 aa)
	AIJ06262.1	Formylmethanofuran dehydrogenase subunit A; COG1229. (561 aa)
	AIJ06263.1	Formylmethanofuran dehydrogenase subunit E; COG2191. (190 aa)
	AIJ06264.1	4Fe-4S ferredoxin; COG1145. (49 aa)
	AIJ06321.1	ABC transporter; COG1123. (555 aa)
	AIJ06322.1	Hypothetical protein. (1091 aa)
	AIJ06324.1	Hypothetical protein. (227 aa)
	AIJ06376.1	Coenzyme F420-reducing hydrogenase, alpha subunit; COG3259. (385 aa)
	AIJ06377.1	Coenzyme F420-reducing hydrogenase maturation factor subunit delta, type 2; COG0680. (155 aa)
	AIJ06378.1	Coenzyme F420-reducing hydrogenase, gamma subunit; COG1941. (227 aa)
	AIJ06379.1	Coenzyme F420-reducing hydrogenase, beta subunit; COG1035. (282 aa)
	AIJ06484.1	Hypothetical protein; COG1693. (539 aa)

Your Current Organism:

Methanocaldococcus bathoardescens

NCBI taxonomy Id: 1301915
Other names: DSM 27223, KACC 18232, M. bathoardescens, Methanocaldococcus bathoardescens Stewart et al. 2015, Methanocaldococcus sp. JH146, strain JH146

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIJ04853.1	AIJ04854.1	JH146_0002	JH146_0003	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	CO dehydrogenase/acetyl-CoA synthase epsilon subunit; COG1880.	0.998
AIJ04853.1	AIJ05006.1	JH146_0002	JH146_0155	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Pyruvate ferredoxin oxidoreductase gamma subunit; COG1014.	0.930
AIJ04853.1	AIJ05007.1	JH146_0002	JH146_0156	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Pyruvate ferredoxin oxidoreductase delta subunit; COG1144.	0.929
AIJ04853.1	AIJ05008.1	JH146_0002	JH146_0157	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Pyruvate ferredoxin oxidoreductase alpha subunit; COG0674.	0.936
AIJ04853.1	AIJ05009.1	JH146_0002	JH146_0158	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Pyruvate ferredoxin oxidoreductase beta subunit; COG1013.	0.937
AIJ04853.1	AIJ05010.1	JH146_0002	JH146_0159	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Formate hydrogenlyase, subunit 2; COG1142.	0.927
AIJ04853.1	AIJ05011.1	JH146_0002	JH146_0160	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	4Fe-4S ferredoxin iron-sulfur binding domain protein; COG1142.	0.933
AIJ04853.1	AIJ05098.1	JH146_0002	JH146_0247	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Formate dehydrogenase subunit alpha; COG0243.	0.916
AIJ04853.1	AIJ05131.1	JH146_0002	JH146_0280	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Molybdopterin oxidoreductase; COG0243.	0.916
AIJ04853.1	AIJ05132.1	JH146_0002	JH146_0281	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Coenzyme F420-reducing hydrogenase, beta subunit; COG1035.	0.905
AIJ04853.1	AIJ05497.1	JH146_0002	JH146_0648	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Formylmethanofuran dehydrogenase subunit B; COG1029.	0.654
AIJ04853.1	AIJ05520.1	JH146_0002	JH146_0671	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Formylmethanofuran dehydrogenase subunit C; COG2218.	0.687
AIJ04853.1	AIJ05522.1	JH146_0002	JH146_0673	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Formylmethanofuran dehydrogenase subunit A; COG1229.	0.660
AIJ04853.1	AIJ05523.1	JH146_0002	JH146_0674	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Formylmethanofuran dehydrogenase subunit D; COG1153.	0.650
AIJ04853.1	AIJ05524.1	JH146_0002	JH146_0675	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Formylmethanofuran dehydrogenase subunit G; COG1145.	0.650
AIJ04853.1	AIJ05525.1	JH146_0002	JH146_0676	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	4Fe-4S ferredoxin iron-sulfur binding domain protein; COG1145.	0.654
AIJ04853.1	AIJ05526.1	JH146_0002	JH146_0677	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	4Fe-4S ferredoxin; COG1146.	0.692
AIJ04853.1	AIJ05997.1	JH146_0002	JH146_1155	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	CO dehydrogenase, catalytic subunit; COG1151.	0.915
AIJ04853.1	AIJ06056.1	JH146_0002	JH146_1214	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Nitrogenase reductase NifH2; COG3640.	0.980
AIJ04853.1	AIJ06082.1	JH146_0002	JH146_1240	CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Glutamate synthase alpha subunit domain protein; COG2218.	0.725

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