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AIJ05503.1 AIJ05503.1 AIJ05504.1 AIJ05504.1 AIJ05520.1 AIJ05520.1 AIJ05523.1 AIJ05523.1 AIJ05524.1 AIJ05524.1 AIJ05553.1 AIJ05553.1 AIJ05596.1 AIJ05596.1 ftr ftr mtd mtd AIJ05879.1 AIJ05879.1 AIJ05880.1 AIJ05880.1 mtrH mtrH mtrG mtrG AIJ04854.1 AIJ04854.1 mtrB mtrB mtrC mtrC mtrB-2 mtrB-2 mtrA mtrA mer mer AIJ05017.1 AIJ05017.1 AIJ05353.1 AIJ05353.1 AIJ05354.1 AIJ05354.1 AIJ05355.1 AIJ05355.1 mtrC-2 mtrC-2 mtrD mtrD mtrE mtrE AIJ05899.1 AIJ05899.1 AIJ05900.1 AIJ05900.1 AIJ05901.1 AIJ05901.1 AIJ05902.1 AIJ05902.1 AIJ05903.1 AIJ05903.1 hmd hmd cbiX cbiX AIJ06259.1 AIJ06259.1 AIJ06260.1 AIJ06260.1 AIJ06261.1 AIJ06261.1 mch mch cbiA cbiA AIJ05394.1 AIJ05394.1 AIJ05497.1 AIJ05497.1 AIJ05498.1 AIJ05498.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIJ05503.1CoB/CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (460 aa)
AIJ05504.1CoB/CoM heterodisulfide reductase subunit A; COG1148. (195 aa)
AIJ05520.1Formylmethanofuran dehydrogenase subunit C; COG2218. (273 aa)
AIJ05523.1Formylmethanofuran dehydrogenase subunit D; COG1153. (133 aa)
AIJ05524.1Formylmethanofuran dehydrogenase subunit G; COG1145. (82 aa)
AIJ05553.1Hypothetical protein; COG1852. (210 aa)
AIJ05596.1Methyl-coenzyme M reductase operon protein D; COG4055. (160 aa)
ftrFormylmethanofuran/tetrahydromethanopterin N-formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (301 aa)
mtdF420-dependent methylene tetrahydro methanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (235 aa)
AIJ05879.1CoB/CoM heterodisulfide reductase subunit C; COG1150. (186 aa)
AIJ05880.1CoB/CoM heterodisulfide reductase subunit B; COG2048. (295 aa)
mtrHTetrahydromethanopterin S-methyltransferase, subunit H; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. (319 aa)
mtrGTetrahydromethanopterin S-methyltransferase, subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (78 aa)
AIJ04854.1CO dehydrogenase/acetyl-CoA synthase epsilon subunit; COG1880. (146 aa)
mtrBTetrahydromethanopterin S-methyltransferase, subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (107 aa)
mtrCTetrahydromethanopterin S-methyltransferase, subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (183 aa)
mtrB-2Tetrahydromethanopterin S-methyltransferase, subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (109 aa)
mtrATetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (253 aa)
mer5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (331 aa)
AIJ05017.1Mur ligase middle domain protein; COG0770. (400 aa)
AIJ05353.1Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (552 aa)
AIJ05354.1Methyl-coenzyme M reductase, gamma subunit; COG4057. (266 aa)
AIJ05355.1Methyl-coenzyme M reductase, beta subunit; COG4054. (447 aa)
mtrC-2Tetrahydromethanopterin S-methyltransferase, subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (265 aa)
mtrDTetrahydromethanopterin S-methyltransferase, subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (229 aa)
mtrETetrahydromethanopterin S-methyltransferase, subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (300 aa)
AIJ05899.1Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (553 aa)
AIJ05900.1Methyl-coenzyme M reductase, gamma subunit; COG4057. (260 aa)
AIJ05901.1Methyl-coenzyme M reductase operon protein C; COG4056. (158 aa)
AIJ05902.1Methyl-coenzyme M reductase operon protein D; COG4055. (163 aa)
AIJ05903.1Methyl-coenzyme M reductase, beta subunit; COG4054. (444 aa)
hmdH(2)-dependent methylene tetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (321 aa)
cbiXSirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (148 aa)
AIJ06259.1Formylmethanofuran dehydrogenase subunit B; COG1029. (317 aa)
AIJ06260.1Formylmethanofuran dehydrogenase subunit B; COG1029. (120 aa)
AIJ06261.1Formylmethanofuran dehydrogenase subunit C; COG2218. (412 aa)
mchMethenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (323 aa)
cbiACobyrinic acid a,c-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (441 aa)
AIJ05394.1Vanadium nitrogenase-associated protein N; COG2710. (351 aa)
AIJ05497.1Formylmethanofuran dehydrogenase subunit B; COG1029. (279 aa)
AIJ05498.1Tungsten-containing formylmethanofuran dehydrogenase subunit B; COG1029. (120 aa)
Your Current Organism:
Methanocaldococcus bathoardescens
NCBI taxonomy Id: 1301915
Other names: DSM 27223, KACC 18232, M. bathoardescens, Methanocaldococcus bathoardescens Stewart et al. 2015, Methanocaldococcus sp. JH146, strain JH146
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