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| | cdhC | CO dehydrogenase/acetyl-CoA synthase beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (467 aa) |
| | AIJ04853.1 | CO dehydrogenase, iron-sulfur subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (151 aa) |
| | AIJ04854.1 | CO dehydrogenase/acetyl-CoA synthase epsilon subunit; COG1880. (146 aa) |
| | cdhA | CO dehydrogenase/acetyl-CoA synthase alpha subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (773 aa) |
| | cdhC-2 | CO dehydrogenase/acetyl-CoA synthase beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (738 aa) |
| | AIJ04862.1 | 2-ketoglutarate ferredoxin oxidoreductase subunit delta; COG1146. (69 aa) |
| | apgM | Phosphonopyruvate decarboxylase-related protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (410 aa) |
| | pgi | Glucose-6-phosphate isomerase; COG0166; Belongs to the GPI family. (408 aa) |
| | pfkC | ADP-specific phosphofructokinase; Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor. (460 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (205 aa) |
| | AIJ04961.1 | Formylmethanofuran dehydrogenase subunit E; COG2191. (199 aa) |
| | AIJ04976.1 | Beta-ketoacyl synthase; COG0183. (392 aa) |
| | mer | 5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (331 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (219 aa) |
| | AIJ05006.1 | Pyruvate ferredoxin oxidoreductase gamma subunit; COG1014. (131 aa) |
| | AIJ05007.1 | Pyruvate ferredoxin oxidoreductase delta subunit; COG1144. (86 aa) |
| | AIJ05008.1 | Pyruvate ferredoxin oxidoreductase alpha subunit; COG0674. (386 aa) |
| | AIJ05009.1 | Pyruvate ferredoxin oxidoreductase beta subunit; COG1013. (295 aa) |
| | AIJ05010.1 | Formate hydrogenlyase, subunit 2; COG1142. (164 aa) |
| | AIJ05011.1 | 4Fe-4S ferredoxin iron-sulfur binding domain protein; COG1142. (141 aa) |
| | AIJ05043.1 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (765 aa) |
| | AIJ05048.1 | Thiamine pyrophosphate protein domain protein TPP-binding protein; COG1013. (243 aa) |
| | AIJ05049.1 | Pyruvate ferredoxin oxidoreductase gamma subunit; COG1014. (180 aa) |
| | AIJ05085.1 | Pyruvate ferredoxin oxidoreductase alpha subunit; COG0674. (366 aa) |
| | AIJ05098.1 | Formate dehydrogenase subunit alpha; COG0243. (497 aa) |
| | AIJ05127.1 | Phosphonopyruvate decarboxylase-related protein; COG3635. (384 aa) |
| | AIJ05131.1 | Molybdopterin oxidoreductase; COG0243. (377 aa) |
| | AIJ05132.1 | Coenzyme F420-reducing hydrogenase, beta subunit; COG1035. (379 aa) |
| | AIJ05140.1 | Aldolase; COG1830. (306 aa) |
| | AIJ05182.1 | Fumarate hydratase; COG1951. (286 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (284 aa) |
| | AIJ05327.1 | 6-phospho 3-hexuloisomerase; COG0794. (177 aa) |
| | sucD | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (288 aa) |
| | AIJ05345.1 | Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; COG0247. (489 aa) |
| | AIJ05353.1 | Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (552 aa) |
| | AIJ05354.1 | Methyl-coenzyme M reductase, gamma subunit; COG4057. (266 aa) |
| | AIJ05355.1 | Methyl-coenzyme M reductase, beta subunit; COG4054. (447 aa) |
| | mch | Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (323 aa) |
| | fae-hps | Bifunctional formaldehyde-activating enzyme/3-hexulo se-6-phosphate synthase; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (379 aa) |
| | rbcL | Ribulose 1,5-bisphosphate carboxylase; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (425 aa) |
| | AIJ05460.1 | Pyruvate carboxylase subunit B; COG5016. (567 aa) |
| | AIJ05461.1 | acetyl-CoA carboxylase, biotin carboxylase; COG0439. (501 aa) |
| | AIJ05497.1 | Formylmethanofuran dehydrogenase subunit B; COG1029. (279 aa) |
| | AIJ05500.1 | Coenzyme F420-reducing hydrogenase, alpha subunit; COG3259. (418 aa) |
| | AIJ05501.1 | Coenzyme F420-reducing hydrogenase, gamma subunit; COG1941. (279 aa) |
| | AIJ05503.1 | CoB/CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (460 aa) |
| | AIJ05509.1 | Aldehyde ferredoxin oxidoreductase; COG2414. (622 aa) |
| | AIJ05520.1 | Formylmethanofuran dehydrogenase subunit C; COG2218. (273 aa) |
| | AIJ05522.1 | Formylmethanofuran dehydrogenase subunit A; COG1229. (546 aa) |
| | AIJ05523.1 | Formylmethanofuran dehydrogenase subunit D; COG1153. (133 aa) |
| | AIJ05524.1 | Formylmethanofuran dehydrogenase subunit G; COG1145. (82 aa) |
| | AIJ05525.1 | 4Fe-4S ferredoxin iron-sulfur binding domain protein; COG1145. (355 aa) |
| | AIJ05526.1 | 4Fe-4S ferredoxin; COG1146. (148 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase, type II; COG0057. (343 aa) |
| | cdhD | CO dehydrogenase/acetyl-CoA synthase delta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family. (396 aa) |
| | cdhE | CO dehydrogenase/acetyl-CoA synthase gamma subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (490 aa) |
| | AIJ05608.1 | Phosphoserine phosphatase SerB; COG0560. (211 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (429 aa) |
| | AIJ05615.1 | Pyruvate kinase; COG0469; Belongs to the pyruvate kinase family. (443 aa) |
| | AIJ05687.1 | Fe-S type, hydrlyase, tartrate/fumarate subfamily, beta subunit; COG1838. (197 aa) |
| | pgk | Phosphoglycerate kinase; COG0126; Belongs to the phosphoglycerate kinase family. (415 aa) |
| | AIJ05710.1 | Dimethylmenaquinone methyltransferase; COG0684. (196 aa) |
| | fbp | Hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (395 aa) |
| | ftr | Formylmethanofuran/tetrahydromethanopterin N-formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (301 aa) |
| | mtd | F420-dependent methylene tetrahydro methanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (235 aa) |
| | AIJ05770.1 | D-3-phosphoglycerate dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (524 aa) |
| | AIJ05879.1 | CoB/CoM heterodisulfide reductase subunit C; COG1150. (186 aa) |
| | AIJ05880.1 | CoB/CoM heterodisulfide reductase subunit B; COG2048. (295 aa) |
| | mtrH | Tetrahydromethanopterin S-methyltransferase, subunit H; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. (319 aa) |
| | mtrG | Tetrahydromethanopterin S-methyltransferase, subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (78 aa) |
| | mtrA | Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (253 aa) |
| | mtrB | Tetrahydromethanopterin S-methyltransferase, subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (107 aa) |
| | mtrC | Tetrahydromethanopterin S-methyltransferase, subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (183 aa) |
| | mtrB-2 | Tetrahydromethanopterin S-methyltransferase, subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (109 aa) |
| | mtrC-2 | Tetrahydromethanopterin S-methyltransferase, subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (265 aa) |
| | mtrD | Tetrahydromethanopterin S-methyltransferase, subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (229 aa) |
| | mtrE | Tetrahydromethanopterin S-methyltransferase, subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (300 aa) |
| | AIJ05899.1 | Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (553 aa) |
| | AIJ05900.1 | Methyl-coenzyme M reductase, gamma subunit; COG4057. (260 aa) |
| | AIJ05903.1 | Methyl-coenzyme M reductase, beta subunit; COG4054. (444 aa) |
| | hmd | H(2)-dependent methylene tetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (321 aa) |
| | AIJ05997.1 | CO dehydrogenase, catalytic subunit; COG1151. (624 aa) |
| | AIJ06059.1 | Transketolase, N-terminal subunit; COG3959. (275 aa) |
| | AIJ06060.1 | Pentose-5-phosphate-3-epimerase; COG0036; Belongs to the ribulose-phosphate 3-epimerase family. (222 aa) |
| | AIJ06061.1 | Transketolase, C-terminal subunit; COG3958. (316 aa) |
| | AIJ06082.1 | Glutamate synthase alpha subunit domain protein; COG2218. (318 aa) |
| | tal | Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | aroA | Fructose-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (273 aa) |
| | AIJ06248.1 | Malate dehydrogenase; COG0039; Belongs to the LDH/MDH superfamily. (313 aa) |
| | AIJ06259.1 | Formylmethanofuran dehydrogenase subunit B; COG1029. (317 aa) |
| | AIJ06261.1 | Formylmethanofuran dehydrogenase subunit C; COG2218. (412 aa) |
| | AIJ06262.1 | Formylmethanofuran dehydrogenase subunit A; COG1229. (561 aa) |
| | AIJ06263.1 | Formylmethanofuran dehydrogenase subunit E; COG2191. (190 aa) |
| | AIJ06380.1 | Fumarate reductase/succinate dehydrogenase flavoprotein domain protein; COG1053. (540 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (356 aa) |
| | sucC | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (365 aa) |
