78 items (Pseudozyma hubeiensis) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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	PHSY_000067	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (644 aa)
	PHSY_000072	DNA helicase I. (1145 aa)
	PHSY_000019	Uncharacterized protein. (334 aa)
	PHSY_000198	DNA polymerase. (1680 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (644 aa)
	PHSY_000355	DNA helicase; Belongs to the MCM family. (731 aa)
	PHSY_000556	DNA_mis_repair domain-containing protein. (831 aa)
	PHSY_000590	DUF1767 domain-containing protein. (468 aa)
	PHSY_000547	ERCC4 domain-containing protein. (851 aa)
	PHSY_000766	DNA ligase. (1078 aa)
	PHSY_000822	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (365 aa)
	PHSY_000863	DNA_MISMATCH_REPAIR_2 domain-containing protein. (182 aa)
	PHSY_000864	DNA mismatch repair protein. (183 aa)
	PHSY_001006	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (992 aa)
	PHSY_001450	Predicted ATPase. (1289 aa)
	PHSY_001366	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1523 aa)
	PHSY_001576	SAE2 domain-containing protein. (477 aa)
	PHSY_001695	Uncharacterized protein. (727 aa)
	PHSY_001681	Single-stranded DNA binding protein. (136 aa)
	PHSY_002226	Endonuclease. (367 aa)
	PHSY_002291	VWFA domain-containing protein. (815 aa)
	PHSY_002284	Uncharacterized protein. (119 aa)
	PHSY_002351	Nuclease. (601 aa)
	PHSY_002307	DNA replication initiation factor. (815 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (850 aa)
	PHSY_002668	Excision repair protein. (316 aa)
	PHSY_002763	Uncharacterized protein. (1098 aa)
	PHSY_002657	Telomere length regulation protein. (1172 aa)
	PHSY_003104	DNA helicase; Belongs to the MCM family. (978 aa)
	PHSY_003067	OrfB_Zn_ribbon domain-containing protein. (678 aa)
	PHSY_000064	Possible DNA polymerase delta subunit. (565 aa)
	PHSY_003357	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (793 aa)
	PHSY_003345	Potential Ku DNA binding protein subunit. (716 aa)
	PHSY_003744	DNA_ligase_OB_2 domain-containing protein. (851 aa)
	PHSY_003868	DNA helicase. (907 aa)
	PHSY_000677	Uncharacterized protein. (868 aa)
	PHSY_003907	DNA helicase; Belongs to the MCM family. (1014 aa)
	PHSY_000865	Meiotic recombination-related protein. (395 aa)
	PHSY_000920	RING-type domain-containing protein. (479 aa)
	PHSY_004522	Uncharacterized protein. (407 aa)
	PHSY_004508	Likely protein kinase. (940 aa)
	PHSY_004513	Serine/threonine-protein phosphatase. (305 aa)
	PHSY_004956	DNA mismatch repair protein. (1023 aa)
	PHSY_005017	Uncharacterized protein. (892 aa)
	PHSY_005028	Uncharacterized protein. (1293 aa)
	PHSY_005177	Uncharacterized protein. (826 aa)
	PHSY_005204	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (961 aa)
	PHSY_005158	HD domain-containing protein. (294 aa)
	PHSY_002293	Deacetylase sirtuin-type domain-containing protein. (1006 aa)
	PHSY_002428	zf-RING-like domain-containing protein. (383 aa)
	PHSY_005820	ATP dependent chromatin remodeling factor. (1105 aa)
	PHSY_005858	Likely protein kinase. (812 aa)
	PHSY_002615	Uncharacterized protein; Belongs to the CGI121/TPRKB family. (342 aa)
	PHSY_005965	Checkpoint protein; Belongs to the HUS1 family. (285 aa)
	PHSY_006018	Mitochondrial genome maintenance protein. (329 aa)
	PHSY_002775	Single-stranded DNA endonuclease. (992 aa)
	PHSY_006165	Uncharacterized protein. (1946 aa)
	PHSY_006302	Uncharacterized protein. (846 aa)
	PHSY_002930	AAA domain-containing protein; Belongs to the AAA ATPase family. (532 aa)
	PHSY_006394	OrfB_Zn_ribbon domain-containing protein. (286 aa)
	KAE1	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (918 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (374 aa)
	PHSY_006514	WD_REPEATS_REGION domain-containing protein. (1424 aa)
	PHSY_006658	Cir_N domain-containing protein. (291 aa)
	PHSY_006522	DNA ligase. (847 aa)
	PHSY_003442	Uncharacterized protein. (1055 aa)
	PHSY_006654	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (339 aa)
	PHSY_006802	Potential translation-regulating helicase. (948 aa)
	PHSY_006929	Uncharacterized protein. (680 aa)
	PHSY_004130	DNA helicase; Belongs to the MCM family. (959 aa)
	PHSY_007437	Topoisomerase acting in meiosis. (299 aa)
	PHSY_004679	Potential GINS DNA replication initiation complex subunit. (329 aa)
	PHSY_004770	DNA repair protein RAD50. (1309 aa)
	PHSY_005418	RAD57 protein. (756 aa)
	PHSY_006562	3'-5' exonuclease domain-containing protein. (590 aa)
	PHSY_006657	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (903 aa)
	PHSY_007107	Potential nuclear DNA repair complex SMC ATPase. (1160 aa)
	PHSY_007147	SP-RING-type domain-containing protein. (312 aa)

Your Current Organism:

Pseudozyma hubeiensis

NCBI taxonomy Id: 1305764
Other names: P. hubeiensis SY62, Pseudozyma hubeiensis SY62

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	MCM7	R9PBY9	R9P1A7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.650
FEN1	PHSY_000064	R9PBY9	R9P330	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Possible DNA polymerase delta subunit.	0.759
FEN1	PHSY_000072	R9PBY9	R9NVK7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase I.	0.528
FEN1	PHSY_000198	R9PBY9	R9NVY0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.780
FEN1	PHSY_000355	R9PBY9	R9NWB2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.900
FEN1	PHSY_000547	R9PBY9	R9NWW3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ERCC4 domain-containing protein.	0.498
FEN1	PHSY_000556	R9PBY9	R9NWU0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA_mis_repair domain-containing protein.	0.786
FEN1	PHSY_000590	R9PBY9	R9NWU8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DUF1767 domain-containing protein.	0.565
FEN1	PHSY_000677	R9PBY9	R9P4S5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.696
FEN1	PHSY_000766	R9PBY9	R9NX34	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.941
FEN1	PHSY_000863	R9PBY9	R9NXB1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.602
FEN1	PHSY_000864	R9PBY9	R9NXG3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA mismatch repair protein.	0.602
FEN1	PHSY_000865	R9PBY9	R9P5D1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Meiotic recombination-related protein.	0.602
FEN1	PHSY_001006	R9PBY9	R9NXV4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.757
FEN1	PHSY_001366	R9PBY9	R9NYN7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.498
FEN1	PHSY_001576	R9PBY9	R9NZ90	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	SAE2 domain-containing protein.	0.768
FEN1	PHSY_001681	R9PBY9	R9NZH1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Single-stranded DNA binding protein.	0.793
FEN1	PHSY_002226	R9PBY9	R9P0D1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Endonuclease.	0.600
FEN1	PHSY_002291	R9PBY9	R9P0I8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	VWFA domain-containing protein.	0.606
FEN1	PHSY_002307	R9PBY9	R9P0S9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication initiation factor.	0.609